Phase 2 Rare Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You are willing to sign a consent form before any trial-related procedures begin
• You are generally active and able to carry out daily activities with little to no limitation (confirm with trial site what this means for your situation)
• You are covered by a social security or health insurance system, where required in your country
• A blood test shows your immune system carries a specific protein marker called HLA-A2 (some patients without this marker may also be included in one part of the trial)
• You have been diagnosed with advanced (Stage IV) lung cancer that has spread and cannot be removed by surgery or fully treated with radiation, your tumor has a specific protein called PD-L1 on at least 50% of cells, and your cancer does not have certain gene changes that would make you eligible for other targeted treatments
• You have not yet received any systemic treatment (such as chemotherapy or immunotherapy) for your advanced cancer — if you had earlier treatment before or after surgery, it must have finished at least 6 months before your cancer was found to have spread
• You have at least one measurable tumour that can be tracked on scans
• Your blood, kidney, and liver test results are within acceptable ranges to safely take part (confirm exact values with trial site)

Who may not be able to join:

• Your cancer could be treated with surgery or another approved treatment known to be beneficial, or you have a known allergy to any ingredients in the trial drugs (OSE2101 or docetaxel)
• You have previously been treated with certain immunotherapy drugs that target PD-1 or PD-L1 (approved or experimental)
• You have an active autoimmune disease, or a history of one that required treatment with steroids or immune-suppressing medications (some exceptions may apply — confirm with trial site)
• You are currently taking part in another clinical trial involving a medication
• You are still experiencing side effects from a previous cancer treatment that have not fully resolved, with some exceptions such as mild nerve-related symptoms or hair loss (confirm with trial site)
• You have another cancer that is currently active or needs treatment — though certain common skin cancers and early-stage cervical cancer do not disqualify you
• You have active brain metastases (cancer that has spread to the brain) or cancer affecting the membranes around the brain — though previously treated and stable brain metastases may be acceptable under specific conditions (confirm with trial site)
• You have active or past inflammation of the lungs (non-infectious pneumonitis) that required steroid treatment, or you have a chronic lung scarring condition
• You have any other medical condition, treatment, or lab result that could interfere with the trial or your ability to participate safely (confirm with trial site)
• You have had a serious heart-related problem — such as a stroke, heart attack, chest pain, dangerous heart rhythm, significant heart failure, or heart muscle inflammation — within the 6 months before starting the trial

Important: Always verify eligibility with the trial site directly before applying.