Phase 1 Kidney Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 years or older
• People with a confirmed diagnosis of non-small cell lung cancer (NSCLC) that has spread or cannot be surgically removed, and where standard approved treatments are no longer an option
• People whose cancer has tested positive for a specific genetic change called a "MET exon 14 skipping mutation," confirmed by a genetic test done within the last 3 months
• People whose cancer can be measured on scans, according to a standard measurement system called RECIST 1.1
• People who are reasonably active and able to carry out daily activities (assessed using a standard scale where a score of 0 or 1 is required)
• People with adequate bone marrow, liver, and kidney function, meeting specific blood test thresholds
• People who agree to follow the trial's contraception requirements during the study
• People who have read and signed a consent form showing they understand the trial and are willing to take part

Who may not be able to join:

• People whose cancer has other known genetic mutations that drive tumour growth
• People who have had major surgery within the 3 weeks before joining the trial
• People who have received chemotherapy, radiotherapy, immunotherapy, or another experimental drug within 3 weeks before starting the trial drug (or within 6 weeks for certain specific chemotherapy types)
• People who have received antibody-based cancer treatment within 4 weeks before the first dose of the trial drug
• People whose cancer got worse while they were previously treated with a type of drug called a MET-kinase inhibitor
• People who have cancer that has spread to the brain, unless all of the following apply: the brain lesions are not causing symptoms and have already been treated; no steroids are currently needed to manage the brain lesions; and scans show the brain lesions have been stable for more than 28 days since the last treatment
• People whose cancer has spread to the lining surrounding the brain and spinal cord
• People with uncontrolled heart conditions, including unstable chest pain, heart failure, a heart attack within the past 12 months, significant irregular heart rhythms, a congenital condition affecting heart rhythm, reliance on a pacemaker, or abnormal heart electrical readings above specific thresholds on a screening test
• People with high blood pressure that has not been controlled despite treatment
• People with a positive pregnancy test at the time of screening (applicable to women of childbearing potential who are sexually active)
• People with significantly altered mental status or a history of serious psychiatric illness that could affect their ability to follow the trial procedures
• People with signs of an active infection currently requiring treatment with systemic medications
• People with other medical conditions that, in the opinion of the treating doctor, make participation inadvisable (for example, pre-existing kidney problems)
• People who are unable or unwilling to swallow capsules, or who have a condition that affects how the body absorbs medication taken by mouth

Important: Always verify eligibility with the trial site directly before applying.