Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• A person must have read, understood, and signed a consent form, and the trial doctor must judge them able to follow the study's requirements.
• A person must have been diagnosed with stage IIIB or higher non-small cell lung cancer, confirmed by a tissue biopsy or similar test (whether newly diagnosed or previously diagnosed).
• The cancer tumour must be small enough to be treated with a precise, focused type of radiotherapy called SBRT (less than 5 cm in size) and must also be suitable for immune checkpoint inhibitor treatment, based on established cancer treatment guidelines.
• A person must be aged 18 or older and under 75.
• A person must have a physical fitness/ability-to-function score (called ECOG PS) of between 0 and 3, meaning they can carry out at least some daily activities (confirm with trial site for exact score requirements).

Who may not be able to join:

• People who are unlikely to follow the study rules or who have previously not complied with trial requirements.
• People with significant problems affecting the liver, kidneys, or heart, such as a past heart attack, ongoing chest pain (angina), or notably raised liver enzyme levels.
• People who have needed to take corticosteroid medications or other drugs that suppress the immune system within the 14 days before joining.
• People who had a serious infection in the 4 weeks before joining, including infections serious enough to require a hospital stay, bloodstream infections, or severe pneumonia.
• People who have needed oral or intravenous antibiotics for a severe ongoing or active infection (including tuberculosis) in the 14 days before joining.
• People with untreated chronic hepatitis B, or hepatitis B carriers whose virus levels are at or above 500 IU/mL, or people with currently active hepatitis C. Note: People with inactive hepatitis B, treated and stable hepatitis B (with virus levels below 500 IU/mL), or fully cleared hepatitis C may still be considered eligible (confirm with trial site).
• People with a known history of HIV infection.
• People who have taken part in another clinical trial or received an experimental treatment within the 28 days before joining.
• People who have a medical reason that would make either the focused radiotherapy (SBRT) or the immune checkpoint inhibitor treatment unsafe for them (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.