Phase 4 Osteoporosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who live independently in their own home or community (not in a care facility)
• People with a body mass index (BMI) over 30, or a BMI between 25 and 30 with at least one additional health risk factor (confirm with trial site for what counts as a risk factor)
• People who currently receive regular (at least annual) dental check-ups
• People who have been found to have lower-than-normal bone density — not quite osteoporosis, but in the range known as "low bone mass" — based on a bone density scan of the hip or spine

Who may not be able to join:

• People who weigh more than 450 pounds (due to limits of the bone density scanning equipment)
• People who live in the same household as someone already taking part in the BEACON study
• People who rely on a quad cane or walker and cannot walk independently
• People who have a history of mild cognitive impairment or dementia, or who score below a certain threshold on a memory and thinking assessment
• People who have consumed more than 21 alcoholic drinks per week in the past month, or who have used any illegal drugs other than cannabis
• People whose weight has changed by 5% or more in the past 3 months
• People who have already been doing structured strength training for more than 60 minutes a day, more than 3 days a week, for over 6 months
• People with severe arthritis, an unhealed fracture, chronic injury, or another condition affecting muscles or joints that would make exercise unsafe; or who have had joint replacement or other bone/joint surgery in the past 6 months or have it planned in the next 12 months; or who have had an invasive dental procedure (such as a tooth extraction or implant) in the past 6 months or have one planned in the next 12 months
• People who have osteoporosis, are on prescription medication for osteoporosis, have had certain bone fractures after age 40 (not caused by a fall or accident), or whose fracture risk score is 20% or higher (confirm with trial site)
• People with very high blood pressure (systolic above 180 or diastolic above 110 mmHg) that remains high across repeated measurements
• People with poorly controlled type 2 diabetes, significantly reduced kidney function, liver disease or abnormal liver results, anaemia, abnormal calcium levels, uncontrolled thyroid disease, or vitamin D deficiency below a certain level
• People who have had a stroke, heart attack, heart failure hospitalisation, or a heart procedure in the past 6 months; or who have a range of other serious health conditions including certain lung, nerve, digestive, or circulatory conditions; active cancer treatment within the last 12 months (except certain skin cancers); significant vision or hearing loss; bilateral hip replacement; past or planned weight-loss (bariatric) surgery; or any condition suggesting a life expectancy of less than 3 years
• People who regularly use growth hormones, weight-loss medications, oral steroids, or certain diabetes medications (such as insulin, thiazolidinediones, or canagliflozin); people with a known allergy to bisphosphonates; or people with significant prior or recent use of certain bone-related medications including bisphosphonates, zoledronic acid, denosumab, anabolic agents, biotin, or strontium
• People who are unable or unwilling to arrange their own transport to study visits, follow the study protocol (including the possibility of being randomly assigned to a group), or attend all required data collection visits
• People currently participating in another research intervention study; people planning to be away for more than one month at a time during the first 6 months of the study; people unwilling to give informed consent (including consent for the trial site to access personal electronic health records); or people considered unsuitable for any other reason by the research team

Important: Always verify eligibility with the trial site directly before applying.