Phase 4 ADHD Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People of any gender who are US military veterans between the ages of 18 and 65 years old.
• People who are able to make their own decisions and sign consent forms without needing someone else to decide for them.
• People who have been diagnosed with PTSD based on a specific set of recognised symptoms, confirmed using a standardised assessment tool called the CAPS-5.
• People whose CAPS-5 assessment score from the past month is 26 or higher, indicating a certain level of PTSD severity.
• People who feel their thinking, memory, or mental sharpness has been affected, as measured by a self-reported questionnaire called the NeuroQoL Cognitive Function form, with a score of 25 or lower.

Who may not be able to join:

• People who have been diagnosed with bipolar I disorder, schizophrenia, or other psychotic disorders (as identified by a specific diagnostic interview called the MINI).
• People whose psychotic symptoms are severe enough that a treating clinician judges that antipsychotic medication is needed.
• People who have had a moderate or severe substance use disorder (other than caffeine or nicotine) in the past two months. People who use alcohol or cannabis but do not meet the threshold for moderate or severe disorder may be considered at the investigator's discretion, however all participants must agree to avoid illicit drugs and THC-containing cannabis products throughout the study.
• People who have a history of severe traumatic brain injury, as defined by a specific medical classification method.
• People who have been diagnosed with dementia or a related condition that causes progressive decline in thinking and memory, based on clinical records.
• People whose risk of suicide is high enough to require hospital-level care, or who have had certain types of serious suicidal thoughts (Type 4 or Type 5 on a standard rating scale) or any suicidal behaviour in the past two months.
• People who are currently pregnant, breastfeeding, or planning to become pregnant at any point during the study. People who could become pregnant must have a negative pregnancy test at the start of the study and must agree to use an accepted form of contraception throughout.
• People who have taken certain medications within two weeks before the start of the study, including other experimental drugs, any form of methylphenidate (MPH), antipsychotics, mood stabilisers, MAO inhibitors, stimulants, atomoxetine, or bupropion.
• People who are currently receiving or have recently completed a recognised trauma-focused therapy for PTSD within two weeks before the study starts. Supportive counselling may be continued during the study.
• People who have a significant uncontrolled medical or surgical condition that would make taking methylphenidate (MPH) unsafe, or who have a known terminal illness.
• People who have previously had an allergic reaction to any form of methylphenidate (MPH).
• People who are currently seeking legal compensation for a psychiatric condition outside of the standard Veterans benefits process.
• People who are currently taking part in another clinical trial for PTSD treatment.

Important: Always verify eligibility with the trial site directly before applying.