Phase 2 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with squamous cell carcinoma (a type of cancer) of the oropharynx (the middle part of the throat, including the back of the mouth and base of tongue), confirmed by a tissue test
• People whose treatment plan requires radiation to both sides of the neck, based on current medical guidelines, and who meet specific lymph node staging criteria (confirm with trial site for details on staging categories)
• People whose tumour comes close to, but does not cross, the midline (centre line) of the throat, as confirmed by scans or a specialist doctor
• People who have had a CT scan with contrast dye and/or an MRI with contrast dye within the past 56 days, showing no cancer spread to lymph nodes on both sides of the neck
• People who have had a PET/CT scan within the past 28 days, showing no cancer spread to lymph nodes on both sides of the neck
• People whose tumour tissue has tested positive for a protein called p16, with moderate to strong staining in at least 70% of the cells tested
• People who are able to provide their smoking history before joining the trial
• People whose cancer can be measured using standard imaging measurement guidelines (called RECIST 1.1)
• People with a general health and activity level rated at 0 or 1 on a standard scale (meaning fully active or able to carry out light activity), assessed within the past 56 days
• People aged 18 or older
• People with adequate blood cell counts, kidney function, and liver function, confirmed by blood tests within the past 14 days

Who may not be able to join:

• People whose tumour crosses the midline of the throat, regardless of its size or stage
• People who have cancer spread to lymph nodes on both sides of the neck (called bilateral neck adenopathy)
• People whose primary tumour site was completely surgically removed during a diagnostic procedure before imaging or physical examination by the registering doctor
• People whose cancer has tested negative for the p16 protein
• People with clear clinical or scan evidence that the cancer has spread to distant parts of the body, or to lymph nodes below the collarbone
• People who have previously received systemic treatment (such as chemotherapy or immunotherapy) for this cancer
• People who have previously had head or neck surgery involving the neck area, including surgical removal of a lymph node for biopsy
• People who have previously had radiation therapy to the head or neck in a way that would overlap with the areas to be treated in this trial
• People with a known allergic reaction to a substance called Technetium-99m-tilmanocept, which is used in a type of imaging scan in this trial
• People with other serious uncontrolled health conditions, including other active cancers, active infections, unstable heart conditions, certain heart rhythm problems, or mental health or personal circumstances that may make it difficult to follow the trial requirements
• People who are pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.