Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with stage IV lung cancer (either small cell or non-small cell type), confirmed by a tissue or cell sample — or you have stage III lung cancer but are not considered a candidate for standard treatment.
• You fit into at least one specific patient subgroup defined by the trial (confirm with trial site).
• Your doctor plans to treat you with a chemotherapy regimen that includes at least one specific type of chemotherapy drug, such as platinum, taxane, or similar agents (confirm with trial site for the full list).
• Your cancer can be measured on scans using standard criteria (called RECIST 1.1).
• You are 18 years of age or older.
• You are well enough to carry out basic daily activities, rated on a standard scale from 0 (fully active) to 3 (limited self-care) — though a rating of 3 may have additional restrictions (see exclusions below).
• You may have had previous cancer treatments — there is no limit on how many prior treatments you have received.
• If you have cancer that has spread to the brain, you may still be eligible as long as you do not currently need steroids to treat it, have not had brain radiation within the last 7 days, and the brain disease is stable.
• If you are living with HIV, you may be eligible if your virus is well controlled (very low viral load or a healthy immune cell count) and you have not had a serious HIV-related infection in the past 12 months.
• If you are a woman who could become pregnant, you must be willing to use effective contraception during the study and for at least 6 months after your last dose.
• If you are a man who could father a child and your partner could become pregnant, you must agree to use effective contraception from the start of treatment, throughout the study, and for 6 months after your last dose.
• You are able to understand and are willing to sign the required consent forms.

Who may not be able to join:

• You are only receiving targeted therapy (such as TKI drugs) or immunotherapy without any chemotherapy.
• You are currently taking part in another experimental cancer treatment trial.
• You have a performance status of 3 (significant activity limitations) and also have liver or kidney problems.
• You have signs of a bowel blockage, or you routinely need fluids, nutrition, or feeding through a tube or IV line.
• You have had major surgery within the last 28 days, or you have major surgery planned during the trial.
• You are still experiencing significant side effects from previous cancer treatments (with some exceptions, such as nerve damage, hair loss, or hormone-related conditions that can be managed).
• You have an uncontrolled serious illness, such as an active infection, uncontrolled heart failure, unstable chest pain, uncontrolled heart rhythm problems, liver cirrhosis, or a mental health or personal situation that would make it difficult to follow the study requirements.
• You have cancer that has spread to the lining around the brain and spinal cord (called leptomeningeal disease).
• You have uncontrolled fluid build-up around the lungs, heart, or abdomen that needs to be drained more than once a month — unless you have a permanent drainage tube in place.
• Your blood calcium level is too high (above 12 mg/dL).
• You are pregnant or currently breastfeeding.

Important: Always verify eligibility with the trial site directly before applying.