Phase 2 Non-Alcoholic Fatty Liver Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with NASH (a type of fatty liver disease) confirmed by a liver biopsy taken no more than 32 weeks before the study screening, with specific scores for fat, inflammation, and scarring in the liver (confirm with trial site for exact score requirements)
• You speak Dutch or English fluently
• You are able to understand the study information and agree to take part

Who may not be able to join:

• You have drunk significant amounts of alcohol (more than about 1–2 drinks per day on average) for more than 3 months in a row during the past year
• You have severe liver scarring (cirrhosis) or liver cancer
• You have hepatitis B or hepatitis C
• You have an autoimmune liver condition (where the immune system attacks the liver)
• You have Wilson's disease (a condition affecting copper in the body)
• You have a condition called primary sclerosing cholangitis or primary biliary cholangitis (bile duct disorders)
• You have alpha-1-antitrypsin deficiency or hemochromatosis (inherited conditions affecting the liver)
• You have had a liver transplant in the past, or are currently on a waiting list for one
• You are currently taking pre-, pro-, or synbiotics (gut health supplements)
• You have taken antibiotics throughout the whole body (not just on the skin) in the 3 months before joining the trial
• You are taking certain medications including tamoxifen, methotrexate, or amiodarone
• You have had or are planning to have weight-loss (bariatric) surgery
• You have diabetes currently being treated with a GLP-1 receptor agonist medication (a specific type of diabetes drug, confirm with trial site)
• You have a bleeding disorder
• You have certain abnormal blood clotting or platelet results at screening (confirm with trial site)
• You are on blood-thinning or anti-clotting medication that cannot be temporarily stopped
• You have had a major heart or stroke event (such as a heart attack or stroke) in the 6 months before screening
• You have a long-term weakened immune system, for example due to recent chemotherapy or HIV with a low immune cell count
• You have or have had a serious cancer, unless it was fully treated and in complete remission (some minor skin cancers may be exceptions — confirm with trial site)
• You have a major surgery planned during the time the trial will be running (minor procedures may be acceptable — confirm with trial site)
• You are currently pregnant or breastfeeding
• You have any other condition that, in the doctor's opinion, could affect your safety or ability to take part in the study
• You are currently taking part in another clinical trial

Important: Always verify eligibility with the trial site directly before applying.