Phase 3 Tuberculosis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Your body weight is between 40kg and 90kg, and your body mass index (BMI) is between 15.0 and 28.0 (a measure of weight relative to height)
- You have been diagnosed with tuberculosis (TB) that has been shown through testing to be resistant to at least the drug rifampicin, with test results from within the last 3 months
- Your sputum (mucus coughed up from the lungs) test has come back positive for TB bacteria at a certain level (1+ or higher)
- You are willing to stop all current TB medications and go through a 7-day "washout period" before starting the trial
- If you are a woman, you are not pregnant or breastfeeding, and you agree to use contraception throughout the treatment; or if you are a man, your partner agrees to use contraception throughout the treatment
Who may not be able to join:
- You are allergic to any of the study drugs or their ingredients
- You have a history of alcohol dependence or drug abuse
- Your TB has spread through the bloodstream or to parts of the body outside the lungs
- Pre-screening tests showed your TB is resistant to more than 4 of the 8 TB drugs being used in this study
- You have previously taken the drug Bedaquiline
- You are HIV-positive
- Your recent lab (blood or urine) tests show significant abnormalities
- You have a history of a specific serious irregular heartbeat called torsades de pointes, or heart-related risk factors for it
- Your heart's electrical activity (measured by an ECG) shows a reading called QTcF above 450ms, or you have other significant heart rhythm problems that may need treatment
- You have a documented heart or cardiovascular disease
- You have significant nerve damage (peripheral neuropathy) that is severe or likely to get worse, or you have inflammation of the optic nerve (the nerve connecting your eye to your brain)
- You have any serious disease affecting the heart, kidneys, liver, blood, immune system, hormones, or joints, or you have been diagnosed with cancer
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Naihui Chu, Ph.D, Beijing Chest Hospital affiliated to Capital Medical University
Phone: 010-89509312
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Sputum Culture Conversion Rate at Week 24
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.