Phase 2 PTSD Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who are at least 18 years old at the time of signing the consent form
- People who are U.S. Military Veterans
- People who are currently receiving services from VA Palo Alto Healthcare System, VA San Francisco Healthcare System, or VA NorCal Healthcare System
- People who can speak and read English fluently
- People who agree to have their study visits recorded by audio and/or video
- People assigned to the MDMA-assisted therapy group who are able to identify suitable support person(s) to stay with them on the evenings of MDMA sessions
- People who meet the clinical diagnostic criteria for PTSD (post-traumatic stress disorder) with symptoms lasting at least 6 months
- People who have had severe PTSD symptoms in the past month
- People who weigh at least 48 kilograms (approximately 106 pounds)
- People who are not pregnant, not planning to become pregnant, and not breastfeeding
- People who are able to give informed consent to participate
Who may not be able to join:
- People with a history of certain medical conditions that could make receiving a type of drug called a sympathomimetic (a stimulant-type medication) harmful to them (confirm with trial site)
- People with a current unstable medical illness
- People with heart-related conditions, including uncontrolled high blood pressure, certain irregular heart rhythms, or other heart conditions
- People who have received electroconvulsive therapy (ECT), ketamine-assisted therapy, or have used ketamine within the 12 weeks before enrolling
- People with moderate or severe alcohol or cannabis use disorder within the past 12 months
- People with any level of active substance use disorder involving illicit drugs (other than cannabis) or misuse of prescription drugs within the past 12 months
- People who are currently at serious risk of suicide
- People who are unable or unwilling to stop or safely reduce certain medications that are not permitted during the trial
- People who have ever used MDMA (also known as ecstasy) at any point in their life
- People who are currently enrolled in another clinical study
- People with a personal history of a primary psychotic disorder, Type I bipolar disorder, severe personality disorder, an eating disorder involving compensatory behaviours, or a depressive disorder with psychotic features
- People who lack social support or a stable living situation
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Trisha Suppes, MD, PhD, VA Palo Alto Healthcare System / Stanford University
Phone: 650-849-0161
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in Clinician Administered PTSD Scale (CAPS-5) Total Severity Score
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.