Phase 4 Interstitial Lung Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are at least 18 years old
• You have been diagnosed with sarcoidosis confirmed by tissue testing, following internationally recognised medical guidelines
• You have a non-severe form of sarcoidosis affecting the eyes that needs treatment taken by mouth or injection (systemic treatment)
• You have a non-severe form of sarcoidosis affecting the skin that needs systemic treatment
• You have a non-severe form of sarcoidosis affecting the bones that needs systemic treatment
• You have a non-severe form of sarcoidosis affecting the joints that needs systemic treatment
• You have a non-severe form of sarcoidosis causing high calcium levels in the blood that needs systemic treatment
• You have a non-severe form of sarcoidosis affecting the nerves outside the brain and spinal cord that needs systemic treatment
• You have a non-severe form of sarcoidosis affecting the ears, nose, or throat that needs systemic treatment
• You have higher-than-normal calcium levels in your urine, as measured by a 24-hour urine test or a standard urine sample (confirm with trial site for exact values)
• You are willing and able to sign a consent form agreeing to take part
• You are registered with the French national social security system

Who may not be able to join:

• You have a severe form of sarcoidosis that requires stronger treatments such as certain immune-suppressing drugs, anti-TNF antibody therapy, or high-dose steroid injections into a vein
• You have used immune-suppressing medications within the last 3 months, or are currently taking them
• You have taken steroid tablets (such as cortisone or prednisone) and have not been off them for at least 3 months
• You have previously taken antimalarial drugs such as hydroxychloroquine or chloroquine, and have not been off them for at least 12 months
• You are currently taking any of the following medications: citalopram, escitalopram, hydroxyzine, domperidone, or piperaquine
• You have a known allergy or intolerance to hydroxychloroquine, chloroquine, related drugs, or prednisone
• You have a heart rhythm problem shown on a heart tracing (ECG), specifically a prolonged QT interval (note: atrial fibrillation alone does not automatically exclude you — confirm with trial site)
• You have severe eye problems, eye problems that would prevent regular eye monitoring during the trial, or a history of damage to the central part of the retina (maculopathy or retinopathy)
• You have end-stage (very advanced) disease of the lungs, liver, heart, or kidneys
• Your sarcoidosis affects the brain or spinal cord (central nervous system)
• Your sarcoidosis affects the heart
• You have signs of an active infection (including herpes or chickenpox viruses), a serious unstable health condition (such as moderate to severe heart failure), or unstabilised psychosis
• You have a long-term infection with HIV or hepatitis B virus (HBV)
• You have tuberculosis (TB) that has not been treated, whether it is active or a latent (dormant) infection
• You are pregnant or breastfeeding (a pregnancy blood test will be done at the start of the trial)
• You need to receive a live vaccine during the period you are in the trial
• You are unable to understand the trial information or to give informed consent, or are otherwise unable to meet the requirements of the study
• You are already taking part in another clinical trial involving a treatment intervention
• You are under legal court protection
• You are not able or willing to use effective contraception throughout the duration of the trial (confirm with trial site for the full list of accepted contraceptive methods)

Important: Always verify eligibility with the trial site directly before applying.