Phase 1 Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are already enrolled in a specific NINDS research study for Multiple Sclerosis (MS) OR a specific NINDS research study for PML (a rare brain infection), OR you have been evaluated and show signs of another brain or spinal cord inflammatory condition.
• You have been diagnosed with MS based on recognized medical guidelines, OR diagnosed with a confirmed brain infection called PML, OR have another suspected or confirmed inflammatory condition of the brain or spinal cord (such as MOGAD, NMOSD, Behçet's syndrome, or neurosarcoidosis).
• If you are in the "other neuroinflammatory disease" group, you must have had a recent brain MRI (within the last month) showing a specific type of contrast enhancement, suggesting active inflammation.
• You are 18 years of age or older.
• You are able to understand and are willing to sign a consent form agreeing to take part.
• You are willing to follow all study procedures and are available for the full duration of the study.

Who may not be able to join:

• You are currently pregnant or breastfeeding.
• You have a medical reason why you cannot have an MRI with contrast dye or cannot safely use a 3 Tesla MRI scanner.
• You have other medical conditions that could make it unsafe or difficult for you to take part in the study.
• You weigh more than 350 lbs (158 kg) or your body size means you cannot fit inside the MRI or PET scan machines.
• You have severe claustrophobia (fear of enclosed spaces) that does not improve even with anti-anxiety medication taken by mouth.
• Your liver enzyme levels (specific blood tests called alkaline phosphatase, AST, or ALT) are too high, unless there is a known non-liver-related reason for this.
• Your bilirubin level (a substance measured in a blood test) is too high, unless there is a known non-liver-related reason or a condition called Gilbert's syndrome.
• Your kidneys are not working well enough, based on a specific calculation using a blood test result.
• If you are a woman who could become pregnant, you are unable or unwilling to use highly effective birth control for at least one month before the study begins and throughout your participation.

Important: Always verify eligibility with the trial site directly before applying.