Muscular Dystrophy Trial, By Invitation

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

If you have Myotonic Dystrophy Type 2 (DM2):

• You are between 30 and 65 years old
• You have been diagnosed with DM1 or DM2 through genetic testing or by a doctor's assessment (if diagnosed by assessment only, a close blood relative must have had a positive genetic test)
• You have symptoms or signs of weakness in the muscles closest to the center of your body (such as hips or shoulders)
• You can walk on your own (using a cane or walking stick is fine)
• You are willing and able to give your written agreement to take part in the study

If you have Myotonic Dystrophy Type 1 (DM1):

• You are between 30 and 65 years old
• You have been diagnosed with adult-onset DM1 through genetic testing or by a doctor's assessment (if diagnosed by assessment only, a close blood relative must have had a positive genetic test)
• Your first symptoms began between the ages of 20 and 40
• You have symptoms or signs of weakness in the muscles farther from the center of your body (such as hands or feet) and muscle stiffness
• You can walk on your own (using a cane or walking stick is fine)
• You are willing and able to give your written agreement to take part in the study

If you are a Healthy Volunteer:

• You are between 30 and 65 years old
• You can walk on your own
• You are willing and able to give your written agreement to take part in the study

Who may not be able to join:

For people with DM1 specifically:

• Your DM1 symptoms started before age 20 (known as congenital or childhood-onset DM1)
• You have been diagnosed with dementia, epilepsy/seizures, stroke, multiple sclerosis, Parkinson's disease, or another condition that affects the brain or nervous system

For everyone (DM1, DM2, and healthy volunteers):

• You have a pacemaker, defibrillator, or any metal implant in your body that is not safe to use inside an MRI scanner
• You experience severe anxiety in enclosed spaces (claustrophobia)
• You have been diagnosed with dementia, epilepsy/seizures, stroke, multiple sclerosis, Parkinson's disease, or another condition affecting the brain or nervous system
• You are currently experiencing a significant mental health condition, or have issues with alcohol or substance use
• You have a serious medical condition that would make MRI scanning or movement/strength testing unsafe
• You are taking medications that cause significant drowsiness or affect your thinking, unless you have been on the same dose for at least 3 months before the study visit
• You are currently pregnant
• You weigh more than 400 pounds, as the MRI table may not be able to safely support you
• You are unwilling or unable to give your written agreement to take part

If you take part in a spinal fluid (lumbar puncture) procedure:

• You have taken blood-thinning medications (such as aspirin or similar drugs) within the last 7 days
• You take anticoagulant medications such as warfarin (Coumadin)
• You have a history of bleeding disorders
• Your platelet count (a measure of blood clotting ability) was below 150,000 in the last 6 months
• You have any hardware such as pins, screws, or rods in your lower back area

Important: Always verify eligibility with the trial site directly before applying.