Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be 18 years of age or older
• You must have a type of brain tumor called an IDH-wildtype glioma (grade 2, 3, or 4), confirmed by a tissue sample test
• Your tumor must have a specific genetic change called an FGFR-TACC gene fusion, found through an approved genetic test
• Your brain tumor must have come back or gotten worse after at least one previous treatment, such as surgery, radiation, or chemotherapy
• Your tumor must be measurable on an MRI scan taken before treatment begins
• You must be well enough to carry out basic daily activities (your doctor will assess this using a standard scale)
• Your blood counts must meet minimum levels: enough white blood cells, red blood cells, and platelets (confirm with trial site)
• Your liver must be working well enough, based on blood test results
• Your kidneys must be working at least at a minimum level, based on a blood test
• Your blood phosphate level must be within the normal range (treatment to correct this is allowed)
• You must have recovered from any serious side effects of previous surgery, radiation, or chemotherapy
• If you have HIV, you must be on effective treatment with an undetectable level of virus in the last 6 months
• If you have chronic hepatitis B, the virus must be undetectable while on treatment
• If you have had hepatitis C, you must have been successfully treated and cured, or currently be on treatment with an undetectable viral load
• Your heart must be functioning at a certain level, as assessed by your doctor (confirm with trial site)
• If you are able to become pregnant, or if you are a man whose partner could become pregnant, you must agree to use effective contraception during the study and for one month after finishing the study drug
• You must be willing and able to give written consent to take part; a legal representative may do this on your behalf if needed

Who may not be able to join:

• You are currently taking part in another clinical trial involving an experimental treatment
• You have had a serious allergic reaction to a drug similar to the study drug (erdafitinib)
• You are taking certain medications that interfere with how the study drug works in the body (your doctor will check your current medications — confirm with trial site)
• You have another illness that is not well controlled
• You are currently pregnant, as the study drug may harm an unborn baby
• You are currently breastfeeding
• You have a current eye condition affecting the retina, such as central serous retinopathy or retinal pigment epithelial detachment
• You have an abnormal heart rhythm reading on an ECG, specifically a prolonged QTc interval (over 480 milliseconds)
• You have previously been treated with a drug that targets the FGFR pathway (the same type of drug as the study drug)

Important: Always verify eligibility with the trial site directly before applying.