Phase 3 Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with stage III or stage IV melanoma (confirmed by lab testing) and have already tried at least two standard treatments, such as chemotherapy, immunotherapy, or targeted therapy, without success
• You have a good general level of daily functioning, with little to no limitation on activities (confirm with trial site)
• Your doctors expect you to live for more than 3 months
• It has been at least 4 weeks since your last cancer treatment, and any side effects from previous treatment have largely resolved
• You have at least one measurable tumor that can also be injected directly, meeting specific size requirements (confirm with trial site)
• If you have cancer that has spread to the brain, it must be stable, not causing symptoms, not getting worse, and you must not have needed steroid medication for at least 4 weeks
• Your blood counts, kidney function, liver function, and blood clotting are all within acceptable ranges based on recent lab tests (confirm with trial site)
• If you are a woman who could become pregnant, you must have a negative pregnancy test before starting the trial
• Both men and women who could father or become pregnant must use effective contraception during the trial and for 3 months afterward
• If you have a history of genital herpes, at least 3 months must have passed since your last outbreak
• You are willing to sign a consent form and are expected to follow the trial requirements

Who may not be able to join:

• You have serious ongoing health conditions such as uncontrolled diabetes, a severe active infection, or an active stomach or intestinal ulcer
• You have significant heart or blood vessel problems, including severe heart failure, a recent heart attack (within the last 6 months), uncontrolled irregular heartbeat, or poorly controlled high blood pressure (systolic 160 mmHg or higher and/or diastolic 100 mmHg or higher)
• You had a heart stent placed within the last 6 months
• You have a history of melanoma that started in the eye (uveal melanoma), or have had another type of cancer in the past 5 years (with some exceptions for certain early-stage skin or cervical cancers)
• You have a large amount of fluid buildup in your chest or abdomen that is causing symptoms
• You have bone metastases that are not stable or controlled by treatment (confirm with trial site)
• You have an active autoimmune disease that has required medication to control it within the past 2 years (routine hormone replacement therapy does not count)
• You have HIV, another immune deficiency condition, or have had an organ transplant
• You have active hepatitis B or hepatitis C with detectable virus levels in your blood
• You have active tuberculosis or another infection that needs ongoing treatment throughout your whole body
• You have a known history of substance abuse, alcoholism, or drug misuse
• You have taken part in another clinical trial or received antiviral therapy within the past 4 weeks (with a specific exception for some hepatitis B patients)
• You have received a live vaccine within the 4 weeks before starting the trial
• You are currently pregnant or breastfeeding
• The trial doctor has any other reason to believe you should not participate

Important: Always verify eligibility with the trial site directly before applying.