Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People with a general health and activity level rated as fully active or restricted only in strenuous physical activity (as measured by a standard oncology performance scale).
• People newly diagnosed with squamous cell carcinoma (a specific type of cancer) of the mouth lining, confirmed by a tissue biopsy.
• People whose cancer is located in one of these areas: the tongue (main body), floor of the mouth, gums, inner cheek lining, hard palate (back portion), or the molar region.
• People whose cancer is at an intermediate to advanced stage (Stage III to IVB), based on standard cancer staging assessments.
• People whose tumor has been assessed by doctors as able to be fully surgically removed, either now or after an initial course of treatment to shrink it.
• People who are well enough to tolerate the planned treatments, have no medical reasons preventing surgery, and whose scans (chest CT, bone scan, or PET-CT) show the cancer has not spread to distant parts of the body.
• Women of childbearing age (15–49 years old) who have a negative pregnancy test taken within 7 days before treatment begins, and all participants who are able to have children must agree to use effective contraception throughout the trial and for three months after finishing treatment.
• People who have voluntarily signed a consent form and are willing and able to attend follow-up appointments and meet all other study requirements.

Who may not be able to join:

• People who have previously received cancer treatments such as chemotherapy, radiation therapy, or immunotherapy for this condition.
• People who decline to sign the informed consent form.
• People who are unwilling to accept the treatment options in the study, or who are unable to complete treatment or attend regular follow-up appointments due to psychological, social, family, or geographical reasons.
• People with a known allergy to any of the drugs that may be used in this trial.
• People whose general health is too poor to tolerate treatment — for example, if routine blood tests show that haemoglobin, white blood cell count, or platelet levels are below certain thresholds, or if kidney function markers are above a certain level (confirm specific values with the trial site).
• People whose cancer stage does not meet the trial requirements — for example, those with very early-stage oral cancer (T1–2N0) or those whose cancer has already spread to distant parts of the body (M1).
• People whose cancer cannot be surgically removed because it has grown into critical structures such as major blood vessels (e.g., the carotid artery) or vital areas of the brain.
• Women who are pregnant or breastfeeding.
• People who currently have, or have previously had, another type of cancer — with the exception of certain adequately treated skin cancers, cervical carcinoma in situ, or papillary thyroid carcinoma.
• People who have participated in another clinical trial within the past 30 days.
• People with serious illnesses (including mental illness), severely abnormal test results, or other social or personal factors that researchers determine could affect their safety or ability to complete the study.

Important: Always verify eligibility with the trial site directly before applying.