Migraine Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have been diagnosed with migraine (with or without aura) according to standard headache disorder guidelines, or who have ongoing headaches that include migraine episodes — including those who may be overusing pain medications
- People who have had 4 or more headache days in a 28-day period, tracked using a headache diary before joining the trial
- People whose doctor at the trial site has determined that a medication called amitriptyline would be a suitable preventive treatment for their migraines
- People who are able to complete study visits and questionnaires in English
Who may not be able to join:
- People who are currently using amitriptyline, or are currently receiving a type of talking therapy called Cognitive Behavioural Therapy (CBT) specifically for headache treatment
- People who are currently taking another prescribed medication to prevent migraines, if it has been taken within a certain recent time period related to how long that medication stays in the body (confirm with trial site)
- People who are currently receiving Botox injections or a type of medication called CGRP monoclonal antibodies for migraine prevention
- Young people who are currently pregnant
- People who are currently experiencing suicidal thoughts, or who have made a suicide attempt in the past six months, or who have a history of bipolar disorder, a heart condition called prolonged QT, or significant ongoing constipation or slow stomach emptying
- People who have any other health condition that, in the trial doctor's opinion, would make them unsuitable for the study or could interfere with their medical care
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Scott Powers, PhD, Cincinnati Childrens Medical Center, Cincinnati
Phone: 513-636-9739
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in number of headache days; Reduction to a PedMIDAS score of 20 or less
Can't join this trial?
Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.