Phase 2 Melanoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be a kidney transplant recipient whose transplanted kidney is currently working and you are not on dialysis
• You must be 18 years of age or older
• You must have a confirmed diagnosis of one of these skin cancers: melanoma (not of the eye), basal cell carcinoma, Merkel cell carcinoma, or cutaneous squamous cell carcinoma, and standard surgery, radiation, or non-immune-based treatments would not be enough to treat your cancer
• You must have cancer that can be measured by scans or physical exam
• You must be well enough to carry out basic daily activities (a doctor will assess this using a standard scale)
• Your blood counts must meet minimum levels — including white blood cells, infection-fighting cells (neutrophils), and platelets (confirm specific numbers with trial site)
• Your liver function test results must be within an acceptable range (confirm with trial site)
• Your kidney function must be within an acceptable range based on blood tests (confirm with trial site)
• A specific test measuring DNA fragments in your blood (dd-cfDNA) must be within acceptable limits, suggesting your kidney is not being rejected (confirm with trial site)
• If you are a woman who could become pregnant, you must have a negative pregnancy test before starting and must use contraception for at least 5 months after your last dose of the study drugs
• If you are HIV-positive, you must be on an effective treatment with an undetectable level of the virus in your blood
• If you have or have had hepatitis B or C, the virus must be undetectable or successfully treated
• You must be willing and able to sign a consent form, or have a legal representative do so on your behalf

Who may not be able to join:

• You have received a liver, lung, heart, or pancreas transplant, a bone marrow transplant, or a stem cell transplant
• You are unwilling or unable to receive dialysis if your transplanted kidney were to stop working during the trial
• You have previously developed certain antibodies (HLA or non-HLA donor-specific antibodies) that could attack your transplanted kidney (confirm with trial site)
• You have had a rejection episode of your transplanted kidney within the past 3 months
• You have not yet recovered from significant side effects of your most recent cancer treatment
• You have received certain immune checkpoint therapy drugs (other than anti-PD-(L)1 treatments) within the past year
• You are currently taking part in another clinical trial involving experimental treatments
• You have cancer that has spread to the lining around the brain, have more than 3 untreated brain tumours, have an untreated brain tumour larger than 1 cm, or need high-dose steroids for brain-related symptoms
• You have had a severe allergic reaction to any monoclonal antibody (a type of targeted drug) in the past
• You have had allergic reactions to drugs similar to those used in this trial
• You have a serious uncontrolled illness such as an active infection, heart failure, unstable chest pain, or irregular heartbeat
• You are currently pregnant or breastfeeding
• You have certain active autoimmune diseases that affect vital organs, or specific conditions such as Guillain-Barré syndrome, serious blistering skin diseases, Stevens-Johnson syndrome, or toxic epidermal necrolysis
• You have active diverticulitis, an abdominal abscess, a bowel blockage, or cancer spread throughout the abdominal cavity — these will need to be assessed and possibly treated before you could join
• You have a history of significant heart disease (such as a prior heart attack or heart rhythm problems) — additional heart tests may be needed before you can join (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.