Restless Legs Syndrome Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
This trial has four different groups. Here are the requirements for each:
Group 1 – Stroke Patients:
- You have had your first-ever stroke (either a blocked or bleeding type) at least 6 months ago, confirmed by medical records or brain scans
- You have weakness or poor control of one ankle while walking, specifically limited upward foot movement
- Your ankle can still be moved up to at least a neutral (flat) position by someone else
- You are able to walk at least 10 metres, with or without a walking aid
- You have some muscle stiffness (spasticity) in the calf muscles of the affected leg
- You are available for the full study period and willing to take part
- You have no medical reason that would prevent you from using electrical muscle stimulation
Group 2 – People Who Experience Muscle Cramps:
- You regularly experience muscle cramps at night
- You are not currently receiving treatment for muscle cramps
- You are available for the full study period and willing to take part
- You have no medical reason that would prevent you from using electrical muscle stimulation
Group 3 – People with Restless Legs Syndrome (RLS):
- You feel an urge to move your legs, often with uncomfortable sensations, sometimes affecting your arms too
- Your symptoms start or get worse when you are resting or sitting/lying down
- Moving around (such as walking or stretching) partially or fully relieves your symptoms, at least while you keep moving
- Your symptoms are worse in the evening or at night than during the day, or only happen at night
- Your symptoms are not fully explained by another condition, such as leg cramps or habitual foot tapping
- You have been diagnosed with primary RLS, meaning you have one or more of the following: periodic limb movements, a positive response to dopamine-based medication, a close family member with RLS, or no severe daytime sleepiness (confirm with trial site)
- You are available for the full study period and willing to take part
- You have no medical reason that would prevent you from using electrical muscle stimulation
Group 4 – Healthy Participants:
- You do not have any neurological (brain or nerve) condition
- You have no medical reason that would prevent you from using electrical muscle stimulation
- You are available for the full study period and willing to take part
Who may not be able to join:
The following apply specifically to stroke patients:
- You cannot feel light touch on the lower part of your affected leg (tested using a specific touch test)
- You are unable to understand instructions or to give your informed consent to take part
- You have a history of bone, joint, or other nerve/brain conditions that affect how you walk
- You have had surgery to correct a dropped foot, such as ankle fixation
- You are currently taking certain muscle-relaxing or anti-spasticity medications (such as baclofen, tizanidine, tolperisone, benzodiazepines, or dantrolene), or have had botulinum toxin (Botox) injected into your calf muscles in the last 6 months
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: +41216923806
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in maximal voluntary contraction force; Change in NMES-evoked force; NMES-evoked force; Change in estimates of persistent inward current (Delta F assessed with high-density surface electromyography and/ or the torque measured during vibration after the last bout of NMES); Estimates of persistent inward current (Delta F assessed with high-density surface electromyography and/ or the torque measured during vibration after the last bout of NMES)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.