Restless Legs Syndrome
Plain English clinical trial information, updated daily from ClinicalTrials.gov and public government registries. Not medical advice.
How these figures are counted
- Trials on record is every trial tagged to this condition at any stage, except those withdrawn before starting or terminated early. Most are completed rather than ongoing, so this is a measure of research history, not of current activity. It is also smaller than the sitewide "trials tracked" figure, which does include withdrawn and terminated trials.
- Recruiting now counts only trials whose registry status is "Recruiting". Trials listed as not yet recruiting or enrolling by invitation are excluded, so this understates how many may open to new participants soon.
- Australian sites counts trials counted under "Recruiting now" that list at least one Australian site. A site being listed does not mean it is currently enrolling, and Australian trials registered only on ANZCTR are not counted yet, so this understates local availability.
- Phase 3 trials counts trials counted under "Recruiting now" that are at Phase 3.
Find recruiting trials for Restless Legs Syndrome →
Get alerts when Restless Legs Syndrome trials change ↗
Voxsanity currently covers 103 conditions. We are expanding coverage regularly.
Understanding Restless Legs Syndrome
Restless Legs Syndrome (RLS) is a condition that causes uncomfortable sensations in the legs, often described as crawling, itching, tingling, or an irresistible urge to move them. These feelings typically happen when you are sitting still or lying down, and they tend to get worse in the evening or at night. Moving the legs usually brings temporary relief, but this can make it very difficult to fall asleep or stay asleep, which can leave people feeling tired and worn out during the day.
RLS is more common than many people realise. In Australia, it is estimated to affect around one in ten adults to some degree, though the severity varies widely from person to person. It can occur at any age, but it tends to be more noticeable as people get older. Women are diagnosed with it slightly more often than men. In some cases there is a family history of the condition, and it can also be linked to things like low iron levels, pregnancy, or certain other health conditions, which is why a doctor will often run some tests after a diagnosis is made.
When it comes to managing RLS, approaches can range from simple lifestyle changes through to medication, depending on how much the condition is affecting a person's daily life and sleep. Doctors may look at things like sleep habits, iron levels, and any other health factors that could be contributing. Some people find their symptoms are manageable with non-medical strategies, while others may need further support from their GP or a specialist. It is worth having an open conversation with your healthcare team about what options might be suitable for your individual situation.
This overview is an AI generated summary written from public medical sources and checked on a sample basis. It is general information, not medical advice or a diagnosis. Always speak with your doctor about your situation. How we use AI
Can you access treatment for Restless Legs Syndrome in Australia right now? Here's what's publicly known.
- No PBS-subsidised medicines are currently mapped for Restless Legs Syndrome on Voxsanity. Your doctor or pharmacist can advise on what may be available.
- No trials currently recruiting at Australian sites right now. Worldwide trials may still be an option. See the trial list below.
Information on this site does not constitute medical advice. Data is sourced from publicly available government registries. Always consult your doctor before making any health decisions. Trial status should be verified directly with the trial site.
Get a free monthly update for Restless Legs Syndrome
We'll email you what changed each month: new trials, approvals, and PBS decisions. No subscription required.
We store only your email and the condition you choose. No health information is collected. Unsubscribe anytime.
Be first to know when something changes for Restless Legs Syndrome.
Become a founding memberResearch pipeline
Where trials for Restless Legs Syndrome currently sit in the development pipeline. The funnel shape shows how few drugs reach later phases in general; the counts are this condition's actual trial numbers.
Most active research sponsors
Organisations with the most recruiting trials for Restless Legs Syndrome.
Where trials are running
Clinical trial sites for Restless Legs Syndrome by country. Australia is highlighted.
Clinical trials for Restless Legs Syndrome
Showing 25 of 25 trials
The plain English eligibility text on each trial below is an AI generated summary of the official criteria, checked on a sample basis. How we use AI
🇦🇺 NCT00329602 · GlaxoSmithKline Phase 4 · 11 countries
Who might be able to join this trial: - Adults aged 18 to 79 years old, both men and women - Women who either cannot get pregnant (including those who have gone through menopause), or who have a negative pregnancy test and agree to use an acceptable form of birth control during the study - People who have been formally...
NCT02670161 · Endeavor Health Phase 4 · 1 country
Who might be able to join this trial: - You have been diagnosed with one of the following conditions: a brain tumor, epilepsy, migraine, mild cognitive impairment (including concussion), mild traumatic brain injury, multiple sclerosis, neuropathy, Parkinson's disease, restless legs syndrome, or stroke. - You are able t...
NCT02929732 · University Hospital, Montpellier Not Applicable · 1 country
**Who might be able to join this trial:** - You are aged 18 or older but under 75 years old - You speak French - You are able to understand what the study involves - You are willing to sign a consent form agreeing to take part - You are registered with French social security - *(For patients with Restless Legs Syndrom...
NCT03082755 · University of Texas at Austin Phase 4 · 1 country
**Who might be able to join this trial:** - You are 55 years of age or older - You have been diagnosed by a doctor with Alzheimer's-type dementia, ranging from very mild to severe - You show signs of agitation or restlessness at nighttime, based on a specific assessment tool used by the study team - Your doctor agrees...
NCT05321355 · Johannes Gutenberg University Mainz Not Applicable · 1 country
Who might be able to join this trial: - You have been diagnosed with narcolepsy - You have been diagnosed with another neurological sleep disorder Who may not be able to join: - You are under 18 years of age - You are unable to give your own consent to take part and do not have a legal guardian who can do so on your b...
NCT05695963 · University Hospital, Bordeaux Not Applicable · 1 country
**Who might be able to join this trial:** - You are between 18 and 70 years old - You have been diagnosed with restless legs syndrome (RLS) that has no known underlying cause, confirmed by your medical history and meeting 5 specific RLS diagnostic criteria - Your general physical examination results are normal - You ar...
NCT05908214 · University of Lausanne Not Applicable · 1 country
**Who might be able to join this trial:** This trial has four different groups. Here are the requirements for each: **Group 1 – Stroke Patients:** - You have had your first-ever stroke (either a blocked or bleeding type) at least 6 months ago, confirmed by medical records or brain scans - You have weakness or poor co...
NCT06481176 · Stanford University Not Applicable · 1 country
**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with Restless Legs Syndrome (RLS) - Your RLS symptoms are rated as moderate to severe (based on a standard scoring system used by doctors) - You are not currently receiving any treatment for your RLS - You have not be...
NCT06670443 · Cairo University Not Applicable · 1 country
**Who might be able to join this trial:** - You have an urge to move your legs, usually along with uncomfortable sensations (such as tingling or crawling feelings) - Your leg discomfort gets better when you move your legs - Your symptoms are worse when you are resting, sitting, or lying down - Your symptoms are worse a...
NCT06684782 · Siriraj Hospital Not Applicable · 1 country
Who might be able to join this trial: - You have been diagnosed with Parkinson's disease and are between 18 and 80 years old, with your diagnosis confirmed using a specific set of medical guidelines called the UK Parkinson's Disease Society Brain Bank Diagnostic criteria (confirm with trial site) Who may not be able t...
NCT06726785 · HBC Immunology Inc Not Applicable · 1 country
Who might be able to join this trial: - You are able to understand and sign a consent form agreeing to take part in the trial - You have been diagnosed with Restless Legs Syndrome (RLS) by a doctor - You are currently taking a type of medication called a dopamine agonist to treat your condition Who may not be able to...
NCT06747741 · Foundation University Islamabad Not Applicable · 1 country
Who might be able to join this trial: - You are 60 years old or older. - You can be either male or female. - You have been diagnosed with primary Restless Legs Syndrome (RLS), meaning your RLS is not caused by another medical condition (confirm with trial site). Who may not be able to join: - You have a past or curren...
NCT06806891 · Cairo University Not Applicable · 1 country
Who might be able to join this trial: - You are currently receiving hemodialysis treatment (a type of kidney dialysis) - You experience restless leg syndrome (an uncomfortable urge to move your legs, especially at rest) - You are not considered obese (confirm with trial site for specific weight/BMI limits) Who may not...
NCT06863740 · Sunnybrook Health Sciences Centre Not Applicable · 1 country
**Who might be able to join this trial:** - You are 25 years of age or older - You have been diagnosed with Restless Legs Syndrome (RLS) using standard international diagnostic criteria - Your RLS symptoms have not improved enough even after trying standard medications (dopamine-based drugs and/or certain nerve pain me...
NCT06918847 · Dow University of Health Sciences Not Applicable · 1 country
**Who might be able to join this trial:** - You have been diagnosed with knee osteoarthritis (joint wear and tear) that has been graded as moderate to severe (grade 2, 3, or 4) using a standard medical grading system - You have osteoarthritis in one or both knees - You are between 40 and 70 years old - You meet the rec...
NCT07001891 · University Hospital, Bordeaux Not Applicable · 1 country
**Who might be able to join this trial:** - You are between 18 and 70 years old - If you are a patient (not a healthy volunteer): you have been diagnosed with idiopathic Restless Legs Syndrome (RLS) based on your medical history and meeting 5 specific RLS diagnostic criteria (confirm with trial site) - You have a norma...
NCT07083492 · Wuerzburg University Hospital Not Applicable · 1 country
Who might be able to join this trial: - You are currently pregnant or have given birth within the last 3 months - You are 18 years old or older - You are willing and able to sign a form giving your consent to take part in the study Who may not be able to join: - You have already taken part in this same study before -...
NCT07110961 · Siriraj Hospital Not Applicable · 1 country
Who might be able to join this trial: - You have been scheduled for an overnight sleep study in a clinic and have been diagnosed with Restless Legs Syndrome based on recognised international diagnostic guidelines Who may not be able to join: - You have a physical or cognitive condition such as a stroke, dementia, or s...
NCT07144631 · Rhode Island Hospital Not Applicable · 1 country
**Who might be able to join this trial:** - You are 18 years of age or older - You are pregnant and between 21 and 26 weeks along at the time of joining the study - You are carrying one baby, with no known problems found with the baby's development - You have been diagnosed with Restless Legs Syndrome (RLS) by a sleep...
NCT07179406 · University of Alabama at Birmingham Not Applicable · 1 country
**Who might be able to join this trial:** - You have been diagnosed with Restless Legs Syndrome (RLS) - Your RLS medications have not changed significantly in the past 4 weeks - You are willing and able to follow the study's rules and schedule - You are a healthy person without RLS (for the healthy comparison group in...
NCT07199504 · Yunfeng Xia Phase 3 · 1 country
**Who might be able to join this trial:** - You have been receiving regular kidney dialysis (hemodialysis) for at least 3 months - You are between 18 and 75 years old - You have been diagnosed with Restless Legs Syndrome (an uncomfortable urge to move your legs, especially at rest) and your symptoms are rated as modera...
NCT07453862 · Beijing Friendship Hospital Phase 1 · 1 country
Who might be able to join this trial: - You are between 18 and 75 years old (any gender). - You have been diagnosed with Restless Legs Syndrome (RLS) by a neurologist, either the typical form or a variant, using standard international diagnostic guidelines. - Your RLS symptoms are rated as moderate to severe, based on...
NCT07628387 · Riphah International University Not Applicable · 1 country
**Who might be able to join this trial:** - You are pregnant and have been diagnosed with Restless Leg Syndrome (an uncomfortable urge to move your legs, especially at rest). - Your pregnancy is between 20 and 34 weeks along. - You are between 20 and 40 years old. - You are having moderate to severe sleep problems, bas...
NCT07642089 · Riphah International University Not Applicable · 1 country
Who might be able to join this trial: - You are a pregnant woman between 18 and 35 years old. - You are between 24 and 32 weeks pregnant. - You have been diagnosed with Restless Legs Syndrome (RLS), a condition that causes uncomfortable sensations in the legs and an urge to move them. - You are experiencing sleep probl...
NCT07675109 · Noctrix Health, Inc. Not Applicable · 1 country
**Who might be able to join this trial:** - You have signed a consent form approved by an ethics board, can understand the study requirements and device instructions, and can communicate in English. - You have been officially diagnosed by a doctor with primary restless legs syndrome (RLS). - You are willing to keep you...
Advocacy and support in Australia
Organisations that can offer information, support, or connection for Restless Legs Syndrome. Where more than one is listed, they serve different needs or regions, so choose whichever fits your situation.
No Australian group focuses specifically on restless legs syndrome. The Sleep Health Foundation is a good general resource on sleep health.
This is a starting point, not medical advice or an endorsement. Contact details change; search the organisation name to find its current website.