Peripheral Neuropathy

**Who might be able to join this trial:** - You took part in the earlier Droxidopa study called Protocol 302 - You are willing and able to give written consent to participate, and understand you can leave the study at any time without it affecting your future care **Who may not be able to join:** - You are currently t...

Who might be able to join this trial: - People must attend an in-person visit at a participating trial centre for the first appointment. - People with Charcot-Marie-Tooth disease (CMT, any subtype) who have had genetic testing showing a confirmed or likely disease-causing gene change related to CMT. - People with CMT...

Who might be able to join this trial: - People who have a complete spinal cord injury (meaning no movement or feeling below the injury site) at the lower back, mid-body, or lower neck area (between the C5 and C7 vertebrae) - People who have nerve pain every day that rates at least 4 out of 10 in severity, and has been...

Who might be able to join this trial: - The person has had a major limb amputation. - The person is 18 years of age or older at the time of signing the consent form. - The person is considered healthy enough to undergo surgery, in the treating doctor's opinion. - At least one year has passed since the person's most rec...

Who might be able to join this trial: - You must be over 21 years old at the time of the surgery - You have already had, or your doctor has decided you will have, a specific spinal disc device called the Synergy Disc implanted in your neck - Your bones must be fully developed, and you need disc replacement in the neck...

**Who might be able to join this trial:** - People aged 22 to 75 years at the time of enrollment. - People diagnosed with nerve or spinal cord problems in the neck (cervical spine), causing pain, tingling, or weakness along a specific nerve pathway from levels C3 to C7. - People experiencing at least one of the follow...

**Who might be able to join this trial:** - People who have signed a written consent form before any study activities begin. - People who weigh between 40 kg and 120 kg. - People with a confirmed or possible diagnosis of CIDP (a nerve condition), including typical CIDP or certain variants (motor or multifocal CIDP), a...

**Who might be able to join this trial:** - People who are at least 18 years old at the time of signing the consent form. - People who are able to understand the study, agree to take part, and sign a written consent form after being told about the study's goals, methods, possible benefits, and risks. - People who are...

**Who might be able to join this trial:** - People who have been diagnosed with typical CIDP, or a specific variant called multifocal CIDP or motor CIDP, based on the 2021 European medical guidelines for diagnosing CIDP. - People whose nerve conduction or electrical nerve testing results support a CIDP diagnosis, in l...

Who might be able to join this trial: - People who have MDS (myelodysplastic syndrome) or a related blood condition called dysplastic CMML that has come back or stopped responding to treatment, with less than 20% blast cells (abnormal cells) in the blood or bone marrow, and who have already received at least one standa...

Who might be able to join this trial: - People who have been formally diagnosed with hereditary ATTR amyloidosis with polyneuropathy (a genetic condition that damages nerves), sometimes called hATTR-PN. - People whose diagnosis has been confirmed by a genetic test showing a change (variant) in the TTR gene. - People wh...

Who might be able to join this trial: - People who have been diagnosed with painful sciatica (nerve pain that shoots down the leg to or below the knee) and have not had enough relief from standard treatments. - People with a body mass index (a measure of body weight relative to height) below 35. Who may not be able to...

**Who might be able to join this trial:** - You have been diagnosed with a type of slow-growing blood cancer called follicular lymphoma (FL), specifically grade 1, 2, or 3a, confirmed by a biopsy taken within the last 2 years (unless a new biopsy wasn't medically possible) - Your cancer has been tested and confirmed t...

**Who might be able to join this trial:** - You (or your child) must be at least 2 years old and have a body surface area large enough to meet the study's minimum size requirement (confirm with trial site) - You must have a confirmed diagnosis of a PIK3CA-Related Overgrowth Spectrum (PROS) condition or Proteus Syndrom...

**Who might be able to join this trial:** - You have been diagnosed with stage I, II, or III lung cancer (non-small cell type), breast cancer, or ovarian cancer — stage IV does not qualify. - You are planning to start chemotherapy using a taxane-based drug (such as docetaxel or paclitaxel) within 14 days of signing up...

Who might be able to join this trial: - People who have been diagnosed with a Peroxisome Biogenesis Disorder (PBD), which is a rare inherited condition affecting how cells process certain fats and substances - People who have a defect in a single peroxisome enzyme or protein, where the symptoms and presentation are sim...

Who might be able to join this trial: - People who are willing and able to sign a written consent form - People who have facet joint disease or pain caused by a damaged or compressed nerve that could benefit from a minimally invasive, image-guided procedure (for example, where the affected area is near delicate structu...

Who might be able to join this trial: - People who have been diagnosed with Neurofibromatosis Type 1 (NF1), a genetic condition that causes tumours to grow on nerve tissue - People who have been diagnosed with Neurofibromatosis Type 2 (NF2), a condition that causes non-cancerous tumours to grow on the nerves - People w...

Who might be able to join this trial: - People aged 18 to 80 years old, of any gender, who have had nerve pain on one side of the body that has not responded to medication for more than one year, with a pain score above 2 during the first assessment week. - People whose pain medication has remained unchanged for at lea...

**Who might be able to join this trial:** - People who have been diagnosed with a solid tumour (such as rhabdomyosarcoma, Ewing sarcoma, soft tissue sarcoma, or high-grade brain tumours) or a type of blood cancer called acute leukaemia (AML or ALL), where the cancer has come back or has not responded to previous treat...

"Who might be able to join this trial: - You have been diagnosed with an inherited retinal degenerative disease (a genetic condition that causes the retina in your eye to break down over time) Who may not be able to join: - You have glaucoma as your only eye condition - You have diabetic retinopathy (eye damage caused...

Who might be able to join this trial: - You have been diagnosed with Complex Regional Pain Syndrome (CRPS) affecting your arm(s), leg(s), or both - You have been on the same treatment plan for at least 1 month without changes - You have had CRPS for at least 1 year - You meet a specific set of recognised diagnostic sta...

**Who might be able to join this trial:** - People who have been diagnosed with Neurofibromatosis Type 1 (NF1) — either through standard clinical diagnosis criteria or through genetic testing that confirmed an NF1 gene mutation. - People who have at least one plexiform neurofibroma (a type of nerve tumour associated w...

Who might be able to join this trial: - You are of European American background, have a DNA sample available, and have been identified as either a "case" or "control" participant. - You are of African American background, have a DNA sample available, and have been identified as either a "case" or "control" participant....

Who might be able to join this trial: - People aged between 18 and 85 years old - People who have been diagnosed with cardiac amyloidosis (a condition where abnormal proteins build up in the heart), confirmed by a heart tissue biopsy - People who have been diagnosed with amyloidosis confirmed by a tissue biopsy from an...

Who might be able to join this trial: - People who are patients at Cleveland Clinic and have been diagnosed with cervical myelopathy (a condition where the spinal cord in the neck is compressed), without nerve root pain spreading to the arms - People who are scheduled to have a specific type of neck surgery (posterior...

Who might be able to join this trial: - People who have neuropathic pain (nerve-related pain) - People who have ongoing pain that developed after a surgical procedure Who may not be able to join: - People who have had a severe psychiatric (mental health) condition that required a hospital stay at any point in the past...

Who might be able to join this trial: - People aged between 18 and 70 years old - People who have been diagnosed with Complex Regional Pain Syndrome (CRPS) for at least 3 months - People whose average pain level meets the required score on the study's pain rating scale (confirm with trial site) - People who are able to...

"Who might be able to join this trial: - People who have been diagnosed with a malignant peripheral nerve sheath tumor (MPNST), which is a type of cancer that grows in the tissue surrounding nerves, and who agree to take part (or whose parent, legal guardian, or legally authorized representative agrees on their behalf)...

Who might be able to join this trial: - You have had a cut (laceration) to the ulnar nerve at the wrist that has already been surgically repaired. Who may not be able to join: - You currently have or have had certain types of cancer in the past. - You have diabetes or high blood pressure that is not well controlled. -...

Who might be able to join this trial: - Babies (boys or girls) who have a birth-related injury affecting the nerves in one arm or shoulder (on one side only) - Babies who are between 10 and 11 months old - Babies who show at least one of two specific warning signs that the shoulder joint may be at risk of slipping out...

Who might be able to join this trial: - People who are a close blood relative (parent, child, or sibling) of someone diagnosed with SPG4 or who carries a known mutation in the SPAST gene - People aged 18 to 70 years - People who are willing and able to provide written consent to participate Who may not be able to join...

Who might be able to join this trial: - People who have been diagnosed with breast cancer and have received chemotherapy treatment that included a type of drug called a taxane (this applies to both early-stage and advanced/spread breast cancer). - People who developed nerve pain within 6 months of their chemotherapy. -...

**Who might be able to join this trial:** - People who have received a hand transplant (from a donor) on one side of the body, at or near the wrist, and are at an advanced stage of recovery — roughly 12 to 18 months after surgery, when nerve regrowth has reached the fingertips - People who had a complete amputation of...

**Who might be able to join this trial:** *For people with Complex Regional Pain Syndrome (CRPS) — Study A:* - Adults aged 18 or older - People who have been diagnosed with Complex Regional Pain Syndrome (a chronic pain condition) within the last year, or who were diagnosed more than a year ago, where the diagnosis wa...

**Who might be able to join this trial:** - People who are willing and able to sign a consent form agreeing to take part in the study - People who are willing to follow all study procedures and are available for the full length of the study - Men or women between the ages of 18 and 95 at the time of signing the consen...

Who might be able to join this trial: - People who are critically ill, on a breathing machine (mechanical ventilator), and expected to stay in the intensive care unit for more than 3 days - People who are recovering after surgery - People who are 18 years old or older - People who have been classified as having signifi...

**Who might be able to join this trial:** - Children who are between 10 and 17 years old - Children who speak and understand English fluently - Children who have been diagnosed with a condition called CRPS (Complex Regional Pain Syndrome) and are receiving inpatient treatment at the FIRST clinic at CCHMC, having alrea...

**Who might be able to join this trial:** - Adults between 18 and 80 years of age who have nerve pain in their back and/or lower limbs that has lasted more than 3 months after lumbar (lower back) spine surgery, confirmed by a clinical assessment and a specific pain questionnaire score - People whose pain rates above 3...

Who might be able to join this trial: - People who are between 18 and 70 years old. - People who have given their consent to participate. - People who have been referred to have a possible nerve condition called distal symmetric polyneuropathy (DSPN) investigated — this is a condition affecting the nerves in the hands...

Who might be able to join this trial: - A diagnosis of carpal tunnel syndrome, confirmed either through a physical examination or a nerve conduction test (EMG). - Adults aged 18 or older. Who may not be able to join: - People with a known allergy to the local anaesthetic bupivacaine. - People who have used opioid pain...

**Who might be able to join this trial:** - People who have been diagnosed with a chronic acquired nerve condition that affects the protective covering of the nerves (called demyelinating neuropathy) - People aged 18 or older - People who are able to walk at least 20 metres indoors on their own, without another person'...

**Who might be able to join this trial:** - People who have been diagnosed with a condition called IgM monoclonal gammopathy, have specific antibodies (called anti-MAG antibodies) in their blood, and have nerve damage (peripheral neuropathy) linked to this condition - People aged 18 years or older who are being seen an...

Who might be able to join this trial: - People of any age who have been diagnosed with familial dysautonomia (FD), a genetic condition, and have had laboratory testing confirm a specific gene change called the IKBKAP mutation. - People who are able to give their agreement to take part (or, for younger participants, giv...

Who might be able to join this trial: - You have been diagnosed with sciatica by your family doctor (GP) - Your leg pain is rated 6 or higher out of 10 on a pain scale - Your symptoms have lasted for at least 3 weeks but no longer than 8 weeks Who may not be able to join: - You are under 18 years old - You have a cond...

Who might be able to join this trial: - People who have been diagnosed with Type 1 or Type 2 Diabetes - People who currently have a wound or sore on their foot - People who are receiving care through one of three specific University of Iowa Hospitals and Clinics locations: the Iowa River Landing Diabetes Clinic, the In...

**Who might be able to join this trial:** - People who have been diagnosed with Hereditary Spastic Paraplegia (HSP) or a related condition, either through a doctor's assessment or a genetic test - Unaffected family members (a parent, child, sibling, aunt, uncle, or grandparent) of someone diagnosed with HSP or a relate...

Who might be able to join this trial: - People who have been diagnosed with Type 1 or Type 2 diabetes - People who have nerve-related wounds on the bottom of their foot - People who can understand and speak Norwegian well - People who are able to give their own informed consent to participate Who may not be able to jo...

**Who might be able to join this trial:** - You are between 22 and 80 years old - You have been diagnosed with a long-term, hard-to-treat chronic pain condition, such as pain after an injury, pain after surgery (including phantom limb pain), shingles-related nerve pain, complex regional pain syndrome, facial pain, or...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have been diagnosed with pure small fiber neuropathy (with or without problems affecting the autonomic nervous system, which controls things like heart rate and digestion), confirmed by both clinical assessment and a skin biopsy taken wit...

Who might be able to join this trial: - People who have had a diabetic foot ulcer that has fully healed - People who are over 18 years of age Who may not be able to join: - People who are under 18 years of age - People who do not have diabetes - People who are unable to walk - People who currently have a wound that ha...

**Who might be able to join this trial:** - Adults who have a diabetic foot ulcer **Who may not be able to join:** - People who have an allergy to Calamine or Zinc oxide - People whose leg cannot be wrapped in bandaging - People who are unable to attend weekly appointments or visits as needed - People who are unwillin...

**Who might be able to join this trial:** - Adults aged 18 and over who have a solid tumour cancer confirmed by laboratory testing of a tissue or cell sample (Phase IA), OR adults with confirmed pancreatic, colorectal, or breast cancer (Phase IB). - Young people aged 12 to under 18 with a confirmed solid tumour cancer...

Who might be able to join this trial: - People who have been diagnosed with, or are suspected to have, a nerve problem affecting the ulnar nerve at the elbow (the nerve that runs along the inside of the elbow, sometimes called the "funny bone" nerve) - People whose nerve problem has been confirmed by a specific electri...

Who might be able to join this trial: - Adults aged 18 years or older - People who have symptoms of nerve compression in the lower back, such as pain, numbness, or weakness spreading down the leg (sometimes called radiculopathy or neurogenic claudication) - People who have tried non-surgical treatments for at least 6 w...

Who might be able to join this trial: - You have been diagnosed with a non-cancerous brain or nerve tumor (such as a meningioma, pituitary adenoma, or schwannoma) confirmed by a biopsy or medical imaging scan — certain higher-grade meningiomas (WHO grade 2–3) are also included - Your doctors have recommended that you r...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have any type of cancer at any stage, are being treated with any type of chemotherapy, and are expected to live at least 6 months or more - People who have been diagnosed with painful nerve damage caused by chemotherapy, rated at a modera...

Who might be able to join this trial: - People who have been diagnosed with, or are suspected to have, a condition from the group of disorders called RASopathies (such as Neurofibromatosis, Costello Syndrome, or Noonan Syndrome), whether confirmed through genetic testing or by a doctor's assessment. - Family members wh...

**Who might be able to join this trial:** **Healthy volunteers (Part I):** - White males between 18 and 45 years old - People who have not smoked for at least 6 months before the study begins - People with a body mass index (a measure of body weight relative to height) between 18 and 30 - People who are in good genera...

Who might be able to join this trial: - Adults aged 18 years or older - People where optic neuritis (inflammation of the optic nerve) is suspected by their doctor - People who are already scheduled to have an MRI scan to investigate possible optic neuritis - People who are covered by a social security (health insurance...

**Who might be able to join this trial:** - People who have been diagnosed with mild to moderate carpal tunnel syndrome (CTS) in one or both wrists, confirmed by both a physical exam and a nerve conduction test (a test that measures how well electrical signals travel through the nerves), performed within the past year...

**Who might be able to join this trial:** - People who are male or female and aged 18 or older - People who have a diabetic foot ulcer (an open wound on the foot related to diabetes) that is not infected and does not have reduced blood flow, and that needs pressure to be taken off it to heal - People who are able to wa...

**Who might be able to join this trial:** - Both male and female patients are eligible. - There is a minimum age requirement (confirm with trial site for the specific age). - Patients who have social protection coverage (such as health insurance or a social security scheme). - Patients who are able to provide written...

Who might be able to join this trial: - Adults who have diabetes and a foot ulcer or open wound on the foot or lower leg, located below the ankle bone, caused by complications of diabetes, and measuring at least 5 mm across. - People who had an amputation before joining the trial — in that case, the amputation site (st...

**Who might be able to join this trial:** - People who have a history of Heart Failure and have either been hospitalised for it at least once, or have shown clear signs of Heart Failure (such as fluid build-up or pressure problems in the heart) that required water tablets (diuretics) as treatment, along with certain e...

**Who might be able to join this trial:** - People who have been diagnosed with a specific type of nerve pain in one side of the lower back, caused by a slipped disc or narrowing of the spine at one level. - People whose diagnosis has been confirmed by an MRI scan. - People who already have an appointment scheduled fo...

Who might be able to join this trial: - People who have been diagnosed with ATTR amyloidosis, or who carry a known gene variant that causes ATTR amyloidosis but do not yet have symptoms - (Germany only) People who are currently receiving an approved treatment for ATTR amyloidosis, used in the way that treatment is offi...

**Who might be able to join this trial:** - People who are 60 years of age or older, or people who are 50 years of age or older and have been diagnosed with carpal tunnel syndrome or spinal stenosis - People who have been diagnosed with a specific type of heart failure called HFpEF (heart failure with preserved ejectio...

**Who might be able to join this trial:** - You have been diagnosed with a specific nerve condition called CIDP (a type of nerve disease causing weakness and numbness), meeting recognised medical guidelines for a definite, probable, or movement-only form of the condition. - You have never previously been treated with...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with HER2-positive breast cancer - People who are on a waiting list to begin anticancer treatment involving a type of chemotherapy called taxane-based neoadjuvant chemotherapy Who may not be able to join: -...

Who might be able to join this trial: - You have had a lower limb amputation, or have lost feeling in your foot due to diabetic nerve damage, and your condition has been stable for some time - You are able to stand or walk, with the help of a prosthetic limb or a supportive brace - The nerves in your lower leg are stil...

**Who might be able to join this trial:** - People who are willing to participate voluntarily and sign a consent form agreeing to all trial purposes - People aged 18 years or older - People who have been diagnosed with type 1 or type 2 diabetes for at least one year - People whose diabetes medication has not changed i...

Who might be able to join this trial: - You are 18 years of age or older - You are able to read, understand, and agree to take part in the study on your own - You are able to attend follow-up appointments after joining the trial Who may not be able to join: - You currently have cancer, or have been treated for cancer...

**Who might be able to join this trial:** - People who are willing and able to give written consent to take part, or who have a legal representative who can do so on their behalf - People who have been diagnosed through nerve conduction testing with a trapped peroneal nerve (a nerve near the knee) and have had foot dro...

Who might be able to join this trial: - People aged 18 years or older. - People who have been assessed as probably having diabetic nerve damage, confirmed using a specific set of medical criteria that requires all three of the following to be present: symptoms of sensory nerve problems, reduced feeling in the hands or...

Who might be able to join this trial: - Symptoms of hereditary spastic paraplegia (a nervous system condition affecting movement) began before the age of 18. - The person is currently under 30 years old. - A genetic test has confirmed a change in a gene linked to hereditary spastic paraplegia, and — where relevant — th...

Who might be able to join this trial: - People who speak English - People who are 18 years of age or older - People who have been diagnosed by a doctor with carpal tunnel syndrome (CTS), a condition where a nerve in the wrist is compressed causing pain, numbness, or tingling - People whose nerve conduction test (a test...

**Who might be able to join this trial:** - People who have been diagnosed with Neurofibromatosis Type 1 (NF1) — this means having at least two of the recognised signs of NF1 (such as café-au-lait spots, freckles in the armpit or groin, neurofibromas, an eye tumour called optic glioma, Lisch nodules in the eyes, certa...

Who might be able to join this trial: - People who are 18 years of age or older - People who have signed the consent form agreeing to take part in the study - People who have completed autonomic (nervous system) testing along with skin biopsies (small skin samples taken for analysis) Who may not be able to join: - Peo...

**Who might be able to join this trial:** - People aged 18 or older. - People who have completed certain chemotherapy treatments (including taxane, platinum, vinca alkaloid-based chemotherapy, bortezomib, thalidomide, lenalidomide, ixazomib, or brentuximab vedotin) within the last 540 days, or who are currently on ong...

Who might be able to join this trial: - You have been officially diagnosed with amyloidosis, with or without the heart being affected. - You are able and willing to give your consent to take part in the study. Who may not be able to join: - You are not able to give consent, or you have previously said (in writing or v...

Who might be able to join this trial: - You are between 6 and 18 years old at the start of the study - You are currently receiving a medication called vincristine as part of your treatment (specifically during a phase called Delayed Intensification) - You (and/or your parent or guardian) are willing and able to give co...

**Who might be able to join this trial:** - People aged 18 to 80 years old - People who have had a complete peripheral nerve injury in the arm caused by trauma, and who arrive for treatment within 48 hours of the injury - People whose injury affects movement and/or feeling in one of these specific arm nerves: the axil...

**Who might be able to join this trial:** - You have been diagnosed with type 2 diabetes - You are between 20 and 80 years old - Your blood flow to your feet is at an acceptable level, measured by specific tests on your ankle, arm, or toe (confirm with trial site) - You have had a blood sugar test within the last 12 we...

Who might be able to join this trial: - People who had a suspected diagnosis of Guillain-Barré Syndrome (a condition affecting the nervous system) and were treated at the University Hospital of Basel between 1 January 2005 and 28 February 2021. Who may not be able to join: - People who have officially recorded that th...

**Who might be able to join this trial:** - You have symptoms that are typical of nerve pain (such as burning, shooting, or tingling pain) - Your pain has not been helped enough by medication - Your pain has been going on for at least 6 months, is rated 4 out of 10 or higher on a pain scale, and your pain treatment has...

**Who might be able to join this trial:** - You have been diagnosed with a condition called CIDP (a nerve disorder) — either a possible, probable, or confirmed diagnosis, including typical or less common forms. - You have had CIDP for 3 years or less. - You are 18 years old or older. - You have previously been treated...

**Who might be able to join this trial:** - Children and young people aged 21 years old or younger - People who have a solid tumour that tests positive for a protein called B7-H3 (confirmed through a previous biopsy sample, using a specific lab test) - People whose cancer has come back or has not responded to standard...

**Who might be able to join this trial:** - People between 18 and 99 years old - People who have been using a permanently implanted Abbott PROCLAIM XR Dorsal Root Ganglion nerve stimulation device continuously for at least 1 year to treat long-term back and/or leg pain - People who report that their device has provided...

**Who might be able to join this trial:** **For the skin swab part of the study:** - People who have been diagnosed with type 2 diabetes (observation group), or people who have been confirmed not to have diabetes (control group) - People aged 18 or older who, along with their family if applicable, are willing to take...

**Who might be able to join this trial:** - People who are at least 18 years old. - People whose wound has been present for more than 4 weeks but has received less than 1 year of documented medical treatment at the time of joining. - People whose wound measures between 1.0 cm² and 25 cm² at the first screening visit....

**Who might be able to join this trial:** - People who are willing and able to sign a consent form and follow the study requirements - People aged 18 to 75 years old (inclusive) at the time of signing the consent form, of any gender - People who have been diagnosed with a malignant solid tumour, confirmed by laborator...

**Who might be able to join this trial:** - People between 21 and 65 years old - People who have not used cannabis for at least 30 days before joining - People who have had lower back pain lasting three months or longer - People who are not currently taking opioid medications - Women who are able to become pregnant mus...

**Who might be able to join this trial:** - People who have cancer and are about to start their first chemotherapy cycle, with no signs of nerve damage at the time of their initial nerve assessment (the trial aims to enrol at least 75 people in this group) - People who have cancer and have already finished chemotherap...

**Who might be able to join this trial:** - People who have a cancer diagnosis confirmed by laboratory tissue testing, with at least one area where the cancer has spread (a metastatic lesion) that has been referred for palliative radiotherapy (radiation treatment aimed at managing symptoms rather than curing the cance...

Who might be able to join this trial: - People who are between 18 and 65 years old - People who have a tender or trigger point in the piriformis muscle (a muscle deep in the buttock), confirmed by a physical examination Who may not be able to join: - People who have limited hip movement on the side of the affected pir...

**Who might be able to join this trial:** - People aged 18 to 80 years old - People who are scheduled to have one of these specific back surgeries: (1) a minimally invasive spine decompression procedure at two or more spinal levels (such as a discectomy, foraminotomy, or laminectomy); (2) a minimally invasive spinal f...

**Who might be able to join this trial:** - You have been diagnosed with Complex Regional Pain Syndrome (CRPS) affecting one of your arms, along with nerve-related pain - Your CRPS diagnosis was made using a recognised set of medical guidelines called the Budapest criteria (confirm with trial site) - Your nerve pain wa...

Who might be able to join this trial: - People who have been diagnosed with a disc problem in the neck (such as a slipped disc or narrowing of the spinal canal) that is pressing on nearby nerves. - People who have a documented history of neck and/or arm pain, or loss of feeling or movement, linked to the affected area...

**Who might be able to join this trial:** - People who were exposed to the medication patisiran-LNP (also known as ONPATTRO) at any time starting from 12 weeks before their last menstrual period, or at any point during pregnancy. **Who may not be able to join:** - There are no exclusion criteria for this program — no...

**Who might be able to join this trial:** - You must be an adult (18 years of age or older) - Adults who are under legal protection, such as guardianship or curatorship, may also be eligible - You may be eligible if you have been referred to a participating centre because doctors suspect you may have amyloidosis (a co...

**Who might be able to join this trial:** - People who have been diagnosed with thymoma or thymic carcinoma, confirmed by laboratory testing of tissue samples. - People who have already received at least one round of platinum-based chemotherapy, or who have declined standard chemotherapy (with the reason recorded in t...

Who might be able to join this trial: - People who have been diagnosed with Trigeminal Neuralgia or Peripheral Neuropathy - People who are able to understand and are willing to sign a written consent form Who may not be able to join: - People who currently have an active infection - People who currently have active ca...

**Who might be able to join this trial:** - You are a man or woman aged 18 or older - You are willing to follow all study instructions, attend all visits, and take part in all study activities - You have an open (not yet healed) foot ulcer related to diabetes - You have enough blood flow to the affected area, shown by...

Who might be able to join this trial: - People aged 18 or older at the time of signing the consent form - People who have been diagnosed with nerve pain caused by a herniated disc in the lower back, and who have already been scheduled for surgery in a neurosurgery department - People who are covered by a social securit...

**Who might be able to join this trial:** - People aged 18 to 75 years - People who have given their signed agreement to take part - People living with long-term (more than 12 months) neuropathic pain on one side of the body caused by a stroke (either a blocked or bleeding blood vessel in the brain) - People living wi...

Who might be able to join this trial: - People who are 18 years of age or older - People who have a good enough understanding of Dutch or English to participate - People who are able to read and sign a consent form agreeing to take part - People who have been diagnosed with peripheral polyneuropathy (nerve damage affec...

Who might be able to join this trial: - People who have been diagnosed with peripheral neuropathy (nerve damage in the limbs or body) - People who have had nerve pain that has stayed at a constant level for at least one month and who need pain relief medication more than once a week - People whose pain scores at least...

Who might be able to join this trial: - People who have ongoing, long-term nerve pain that is located in a specific area of the body - People whose use of the capsaicin 8% patch has been confirmed as appropriate by a specialist children's chronic pain centre - People where both the child and their parents or guardians...

**Who might be able to join this trial:** - People whose solid tumour has been confirmed by laboratory testing of tissue or cells, and is either locally advanced (unable to be surgically removed) or has spread to other parts of the body, and for whom no standard treatment is available, suitable, or tolerable. - People...

**Who might be able to join this trial:** - People who are able to give written consent to participate - Veterans aged 21 years or older at the time of screening - People who have been diagnosed with neuropathic pain (nerve pain) according to the criteria set by the Neuropathic Pain Special Interest Group of the Inter...

Who might be able to join this trial: - People who are 18 years of age or older - People whose carpal tunnel syndrome (a condition causing hand and wrist pain or numbness) has been confirmed by a nerve conduction study (a test that measures how well nerves carry electrical signals) - People whose symptoms match those t...

Who might be able to join this trial: - People who are older than 18 years of age - People who have signs and symptoms of severe cubital tunnel syndrome (a condition where the nerve at the elbow is compressed), classified as a specific advanced stage known as McGowan-Goldberg grade 3 - People whose nerve testing (using...

**Who might be able to join this trial:** - Adults between 18 and 80 years old (men and women) - People who are willing and able to give consent and attend all required study visits - People whose pain has lasted at least 6 months, is rated 5 or higher out of 10 on average, has been at a similar level for at least the...

**Who might be able to join this trial:** - Adults aged 18 or older who have been diagnosed with nerve damage caused by chemotherapy (called CIPN) that has lasted more than six months after chemotherapy ended - People who have lower leg or foot pain rated at 5 or higher on a scale of 0–10 - People who have already tri...

**Who might be able to join this trial:** - People aged 18 or older - People who have been referred to the Chronic Pain Unit at Hospital Universitario de Gran Canaria Dr. Negrín for ozone therapy as a symptomatic or palliative treatment, because standard treatments are unavailable, have not worked, or carry high risks...

Who might be able to join this trial: - People who have been assessed by a doctor as needing surgery to treat carpal tunnel syndrome Who may not be able to join: - People who have already had surgery on their carpal tunnel syndrome - People who have received a corticosteroid injection (a type of anti-inflammatory trea...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with Guillain-Barré Syndrome (a condition where the body's immune system mistakenly attacks the nerves) - People who are willing to take part in a rehabilitation program while staying in a hospital or care f...

Who might be able to join this trial: - People who have been diagnosed with Type 1 diabetes, Type 2 diabetes, or diabetes caused by another medical condition. - People who are in hospital or attending a clinic for a chronic (long-term, stable) form of nerve-related bone and joint damage in the foot, with no open wounds...

**Who might be able to join this trial:** - People who have had a spinal cord injury for more than one year and whose condition is neurologically stable. - People who have received medical clearance from a doctor to participate in the trial. - People who are able to stand, with or without a walking aid or support devic...

Who might be able to join this trial: - People who are older than 18 years of age - People who are able to give informed consent and fill out questionnaires - People who have already tried at least four weeks of non-surgical treatments (such as shoe inserts, appropriate footwear, or metatarsal pads) without enough impr...

**Who might be able to join this trial:** - You have a serious nerve injury affecting the sciatic nerve, brachial plexus, or another major nerve in your arm or leg, and the injury happened within the past year - You are between 18 and 65 years old **Who may not be able to join:** - You are unable to safely have an MRI...

**Who might be able to join this trial:** - The patient, parent, or guardian must have signed a consent form before any trial-related screening takes place - People aged 2 to 40 years old at the time of signing consent - People diagnosed with MCAP (a condition involving overgrowth and brain blood vessel changes) who a...

Who might be able to join this trial: - Adults over 18 years old who have been diagnosed with a condition called CIDP (a nerve disorder), based on recognised European diagnostic guidelines. - People whose current intravenous immunoglobulin (IVIG) dose, when converted to a weekly under-the-skin (subcutaneous) dose, fall...

Who might be able to join this trial: - People who have given signed consent to participate, including consent for digital photos of their wound - Adults aged 18 years or older - People who have been diagnosed with a long-term (chronic), fluid-producing venous leg ulcer (VLU) or diabetic foot ulcer (DFU) - People whose...

Who might be able to join this trial: - People who are 20 years of age or older - People who have a confirmed diagnosis or a ruling out of ATTR amyloidosis (a condition where abnormal proteins build up in the body's organs and tissues) Who may not be able to join: - Women who are pregnant or currently breastfeeding -...

**Who might be able to join this trial:** - People between 21 and 80 years of age - People who have signed a consent form, or whose legal representative has signed on their behalf - People who are scheduled to receive weekly paclitaxel chemotherapy - People who are also receiving other chemotherapy drugs alongside pacl...

**Who might be able to join this trial:** - People aged 18 or over, of any ethnic background, who have been diagnosed with type 1 or type 2 diabetes - People whose blood sugar control meets a specific level — a blood test result called HbA1c at or below 10% — measured within the past 3 months or at the first study vis...

**Who might be able to join this trial:** - People who have been confirmed through a tissue test (biopsy) to have Stage III colorectal cancer (cancer of the colon or rectum). - People who are planned to receive a specific chemotherapy regimen called modified FOLFOX-6. - People who have no medical reasons preventing th...

**Who might be able to join this trial:** - People who have been clinically confirmed to have carpal tunnel syndrome (CTS) of any severity, meaning they experience numbness, pain, or tingling in the wrist and fingers in the area served by the median nerve - People whose carpal tunnel syndrome symptoms have been present...

Who might be able to join this trial: - You must be an adult (any gender) - You have been diagnosed with type 1 or type 2 diabetes - You live within the local area served by the Family Health Units in the study - You are available to attend group sessions at the scheduled times Who may not be able to join: - You have...

**Who might be able to join this trial:** - People who have been diagnosed with one of the following cancers, confirmed by tissue testing: Synovial Sarcoma, Malignant Peripheral Nerve Sheath Tumour (MPNST), Neuroblastoma, or Osteosarcoma - People within the following age ranges: 2 to 17 years old for Synovial Sarcoma;...

Who might be able to join this trial: - People who have been diagnosed with a solid tumour cancer. - People who are planning to start a specific chemotherapy regimen (listed below) within 3 days after being enrolled in the trial, either before or after surgery: weekly paclitaxel for 12 weeks; weekly paclitaxel for 12 w...

Who might be able to join this trial: - People diagnosed with breast cancer that is hormone receptor positive (HR+) and HER2 negative, and where the cancer has spread locally, come back, or spread to other parts of the body - People who have received no more than 3 previous treatment courses for their advanced or sprea...

Who might be able to join this trial: - People aged 12 to 20 years old (girls or boys) who are living with chronic pain - People who have been formally diagnosed with chronic pain at a Pain Management Centre - People who are currently being treated at a Pain Management Centre, where their pain has not been relieved by...

Who might be able to join this trial: - Adults between 18 and 60 years of age whose bones have finished growing - People who have neck problems (such as spinal cord or nerve root compression) caused by a herniated disc or disc degeneration at a single level in the neck (between the 3rd and 7th neck vertebrae) - People...

Who might be able to join this trial: - People who are scheduled to receive chemotherapy for colorectal cancer, either before surgery, after surgery, or as a first treatment for advanced cancer, as determined by their oncology team - People who are 65 years of age or older at the time of signing the consent form - Peop...

**Who might be able to join this trial:** - You visited the emergency department mainly because of sudden lower back pain that shoots down into your buttock or leg (or you have that shooting/tingling sensation even without much back pain). - You are being sent home from the emergency department (not admitted to hospit...

**Who might be able to join this trial:** - You are 18 years of age or older at the time of signing the consent form - You are reasonably active and able to care for yourself, with only mild limitations on physical activity (confirm with trial site) - You have been diagnosed with a solid tumor that has spread, cannot...

**Who might be able to join this trial:** - People who have been diagnosed with a blood cancer (such as acute leukemia, acute myeloid leukemia, acute lymphoblastic leukemia/lymphoma, or certain types of myelodysplasia), confirmed by a tissue or bone marrow sample - People aged 60 years or younger at the time of signin...

**Who might be able to join this trial:** **Chronic Pain Group (pain lasting more than 6 months):** - You are 18 years of age or older - You own a smartphone and have reliable internet access - In the past week, your pain has been moderate to severe in terms of how intense it feels, how much it gets in the way of dail...

**Who might be able to join this trial:** - People aged 22 to 90 years old, of any gender - Women who are able to become pregnant must be willing to use an accepted form of contraception (such as birth control pills, barrier methods, or abstinence) from the start of the trial and throughout their involvement - The per...

**Who might be able to join this trial:** - People who have been diagnosed with cardiac amyloidosis (a condition where abnormal proteins build up in the heart), confirmed using heart tests such as an ECG and echocardiogram (heart ultrasound), following the guidelines set by the European Society of Cardiology, and who h...

**Who might be able to join this trial:** - You are a man or woman aged 18 or older who has been diagnosed with type 1 or type 2 diabetes - You have a diabetic foot ulcer (a wound on your foot related to diabetes) that is new and has not been infected, and is caused by nerve damage, poor blood flow, or both - You are a...

**Who might be able to join this trial:** - People who have completed a course of chemotherapy using one or more of the following drugs: paclitaxel, docetaxel, oxaliplatin, cisplatin, vincristine, thalidomide, and/or bortezomib - People who have been diagnosed with chemotherapy-induced peripheral neuropathy (CIPN) — a...

**Who might be able to join this trial:** - You are between 18 and 85 years old - You have been diagnosed with Complex Regional Pain Syndrome (CRPS) using a specific set of recognised diagnostic guidelines called the Budapest Clinical Diagnostic Criteria - Your CRPS affects one leg only (not both legs) - You have been...

**Who might be able to join this trial:** - People who are over 18 years old. - People with a life expectancy of more than 12 weeks. - People who are not currently using opioid pain medicines, or whose daily opioid use is below a low threshold (less than 60 mg per day in oral morphine equivalent terms) (confirm with tr...

**Who might be able to join this trial:** - You have been diagnosed with a heart condition called ATTR cardiac amyloidosis (ATTR-CM), confirmed either by a heart tissue biopsy or a specific type of nuclear scan showing Grade 2 or Grade 3 results. - You have been diagnosed with heart failure and have needed water pills...

**Who might be able to join this trial:** - People aged 18 or older who have had a spinal cord injury at any level of the spine and of any severity, where the injury occurred recently (in the early stage after the traumatic event) **Who may not be able to join:** - People who are currently taking anti-seizure (anticon...

**Who might be able to join this trial:** - You are 18 years of age or older and are a US military veteran - You have been diagnosed with long-term nerve pain (chronic neuropathic pain) - You are currently a patient at the Cleveland VA Medical Center and receive care through their Pain Medicine Center - You currently u...

**Who might be able to join this trial:** - You have been diagnosed with a long-term (chronic) pain condition, such as migraines, daily headaches, stomach pain, pain in one limb or joint, low back or chest pain, widespread muscle and joint pain, or a condition called CRPS - If you are taking any medications, you have b...

**Who might be able to join this trial:** - People who have been referred to a participating clinic to be assessed for surgery for lumbar spinal stenosis (narrowing of the lower spine) or cervical radiculopathy (a pinched nerve in the neck) - People aged 18 or older - People who have had an MRI scan within the last 12...

**Who might be able to join this trial:** - You are between 18 and 80 years old - You have chronic pain that has lasted more than 12 months, is moderate to severe, and has been identified by a specialist as nerve-related (neuropathic) pain - Your pain affects one arm or hand only (upper limb), and not both sides - Your...

Who might be able to join this trial: - People who have been diagnosed with a variant (change) in the HPDL gene - The diagnosis may fall under one of several condition names, including HPDL-related hereditary spastic paraplegia (HSP), HPDL-related neonatal mitochondrial encephalopathy, Spastic paraplegia-83 (SPG83), or...

**Who might be able to join this trial:** - People who are at least 1 month old and no older than 21 years of age at the time of joining. - People who have been diagnosed with Juvenile Myelomonocytic Leukemia (JMML) according to the 2022 International Consensus Classification criteria, which involves specific blood te...

**Who might be able to join this trial:** - Adults aged 18 to 75 years who have been diagnosed with chronic neuropathic pain (nerve pain) in the arms or legs that has lasted longer than 3 months. - People whose nerve pain scores 4 or higher on a specific 10-question nerve pain screening tool used at the first appointm...

Who might be able to join this trial: - People who have a nerve injury in the arm, anywhere from the shoulder nerve network (brachial plexus) down to the wrist. - People whose injury affects either mixed nerves (which carry both movement and sensation signals) or motor nerves (which control movement). - People who have...

Who might be able to join this trial: - People who have been diagnosed with breast cancer for the first time by a doctor. - People who have finished chemotherapy (either as a main treatment or after surgery) within the past 3 months, where the chemotherapy drugs used included paclitaxel, vinblastine, or platinum-based...

Who might be able to join this trial: - People who are at least 18 years old. - People who have been diagnosed with diabetes, either currently taking diabetes medication or with two separate blood test results confirming high blood sugar levels (HbA1c over 6.5% and fasting glucose over 126 mg/dL, taken at least one wee...

**Who might be able to join this trial:** - You have been diagnosed with Type 1 or Type 2 diabetes - A doctor has confirmed you have nerve damage in your feet (neuropathy), tested using a simple touch test with a small filament - You have had a foot ulcer (sore) on the bottom of your foot or toe that fully healed with...

Who might be able to join this trial: - People who have been diagnosed with a chronic nerve condition called axonal length-dependent polyneuropathy and/or small-fiber neuropathy, where the cause has not been clearly identified - People who are 60 years of age or older - People of any gender (male or female) may be cons...

**Who might be able to join this trial:** - You are 18 years of age or older - You have a score of 15 or higher (out of 50) on a standard questionnaire measuring how much neck problems affect your daily life - At least three out of four specific physical tests carried out by a clinician suggest you have a pinched or ir...

Who might be able to join this trial: - People who are having surgery to remove a spinal cord tumor Who may not be able to join: - People who have metal implants or devices inside their body, such as a pacemaker, artificial metal heart valve, metal joints, or metal implants, or those who are unable to remove dentures,...

**Who might be able to join this trial:** **For all participants:** - People aged 45 years or older - People who can walk 10 metres on their own without using a walking aid such as a cane or walker - People who are healthy enough to walk on a treadmill for 1 minute at a comfortable, self-chosen pace **For participant...

**Who might be able to join this trial:** - You are able to give your own informed consent to participate - You are 22 years of age or older - You have had ongoing pain in your back, trunk, and/or limbs for at least 6 months - Your average daily pain score is above 60 out of 100 on a pain rating scale, specifically re...

Who might be able to join this trial: - You have been diagnosed with a nerve problem at the elbow, specifically affecting the ulnar nerve (the nerve that runs along the inside of the elbow, sometimes called the "funny bone" nerve) Who may not be able to join: - You have nerve damage or a nerve condition in other parts...

Who might be able to join this trial: - You received treatment with a high-strength capsaicin (chilli pepper extract) skin patch applied to the tailbone area for tailbone pain at some point between August 2016 and August 2022. Who may not be able to join: - You have already received a high-strength capsaicin skin patc...

**Who might be able to join this trial:** - People who are female and aged 18 or older - People who have been confirmed with, or are strongly suspected to have, endometrial, ovarian, fallopian tube, or primary peritoneal cancer, and whose treating doctor has determined they are expected to receive chemotherapy after a...

**Who might be able to join this trial:** - Children aged 12 to 17 years old. - Boys or girls. - People who have had ongoing nerve pain for more than 3 months after surgery or an injury, even after receiving recommended treatments. - People whose nerve pain has been assessed using a specific scoring tool (called DN4)...

**Who might be able to join this trial:** - Men or women of any ethnicity, racial background, or gender identity - People who are fluent in English - People between 18 and 70 years old - People who have a spinal cord injury (complete or incomplete) at a level above the lower back (above L1) - People who have had ongoin...

**Who might be able to join this trial:** - People who have neuropathic pain (nerve pain) following a traumatic spinal cord injury, an amputation, or a brain injury - People whose pain has been ongoing for more than 3 months - People between 18 and 75 years of age - People whose oral pain medications have not changed f...

Who might be able to join this trial: **For patients:** - Adults aged 18 or older who have been diagnosed with polyneuropathy (a nerve condition confirmed by a nerve conduction test) **For healthy volunteers:** - Adults aged 18 or older who are in good general health Who may not be able to join: **For patients:** -...

Who might be able to join this trial: - People who are at least 18 years old. - People who have been diagnosed with polyneuropathy (a condition affecting multiple nerves), confirmed by a nerve conduction study (a test that measures how well nerves send electrical signals). - People who are able to read and understand D...

**Who might be able to join this trial:** - People aged between 18 and 80 years - People who have been diagnosed with carpal tunnel syndrome (CTS) that has no known underlying cause (called "idiopathic" CTS) **Who may not be able to join:** - People who have a known allergy or sensitivity to methylprednisolone (a ster...

**Who might be able to join this trial:** - Women aged 18 or older - People who have recently had surgery for primary breast cancer (cancer that has not spread to other parts of the body) and are receiving follow-up chemotherapy that includes a drug called paclitaxel - People whose only prior chemotherapy (before pacli...

**Who might be able to join this trial:** - People who are older than 18 years of age - People who have diabetes - People who have at least one sign of a bone infection (osteomyelitis), identified by either: a clinical test where a probe reaches the bone along with changes visible on a standard X-ray, OR signs of bone...

Who might be able to join this trial: - People who have pain on one side of the neck that extends into the arm (known as cervicobrachial pain) Who may not be able to join: - People who show signs of serious illness, spinal cord compression in the neck, tumours, rheumatic diseases, or a neurological condition originati...

**Who might be able to join this trial:** - People who are able to give informed consent to take part in research. - People who are 18 years of age or older at the time of giving consent. - People who have been diagnosed with either Type 1 or Type 2 Diabetes. - People who currently have no open sores or ulcers on eith...

Who might be able to join this trial: - You must be over 18 years old - You have been diagnosed with heart failure that is mild to moderate in severity (meaning you may have some symptoms during activity, but you are not severely limited) - You are physically able to exercise - You are currently on a stable treatment p...

**Who might be able to join this trial:** - People who have been diagnosed with a one-sided nerve problem in the lower part of the neck (at the C5-C6 and/or C6-C7 levels), confirmed by an MRI scan - People who have pain and tenderness in active trigger points (tight, sensitive muscle knots) in the upper trapezius musc...

Who might be able to join this trial: - People who have ongoing (chronic) pelvic pain, which is pain in the lower abdomen or pelvis area - People who have pain in the sacroiliac joint, which is located where the lower spine meets the pelvis - People who have pain in the groin area (inguinal pain) - People who have pain...

**Who might be able to join this trial:** - People who are able to sign and date a consent form agreeing to take part. - People aged 18 years or older. - People who have been diagnosed with diabetes by a doctor, or whose test results meet the American Diabetes Association's criteria for diabetes. - People who have an o...

**Who might be able to join this trial:** - You have neuropathic pain (nerve pain) that is either central (from the brain or spinal cord) or peripheral (from nerves in the body). - Your pain has been ongoing for more than 6 months and rates at least 4 out of 10 in severity. - Your pain is present most days — at least 4...

**Who might be able to join this trial:** - You are between 20 and 60 years old. - You are male or female. - An ultrasound scan has shown you have mild-to-moderate carpal tunnel syndrome (a condition where a nerve in your wrist is compressed, causing pain and numbness). - You have had numbness and pain in the thumb, in...

"Who might be able to join this trial: - People who have diabetes and currently have a diabetic foot ulcer (an open sore or wound on the foot related to diabetes) Who may not be able to join: - People who have problems with memory, thinking, or mental functioning - People who are currently taking medication that suppr...

Who might be able to join this trial: - People who have been diagnosed with diabetes and are between 18 and 80 years old - People who experience pain equally on both sides of the lower legs or feet, with or without unusual skin sensations - People whose symptoms have been present for more than 6 months - People whose p...

**Who might be able to join this trial:** - People who have been diagnosed with nerve damage (called CIPN) in their legs or feet lasting 90 days or longer, caused by certain cancer treatments — including specific chemotherapy drugs (vinca alkaloids, taxanes, bortezomib, thalidomide, or platinum-based drugs) or radiatio...

**Who might be able to join this trial:** - Adults aged 18 or older who have been diagnosed with long-term nerve pain caused by a peripheral nerve injury, where the pain is ongoing or recurring, started after a nerve injury, and is felt in the area that nerve controls - People whose pain improved by at least 50% after...

Who might be able to join this trial: **Part 1 (Observation phase — all participants start here):** - Children who are older than 12 months and up to 8 years old at the time of joining the study - Children who have been diagnosed with Neurofibromatosis Type 1 (NF1) based on the updated 2021 diagnostic guidelines - Chi...

**Who might be able to join this trial:** - People aged 18 or older - People diagnosed with one of these types of amyloidosis: transthyretin amyloidosis caused by a genetic mutation (hereditary TTR), transthyretin amyloidosis not caused by a mutation (wild-type TTR), or light chain amyloidosis (AL) - People who are mem...

**Who might be able to join this trial:** - People aged 18 or older who have been diagnosed with diabetes (any type) for 5 years or less - People whose blood sugar control has been stable for the past three months, with a blood sugar marker (called HbA1c) below 9 at the time of joining - People who have signs of nerve...

Who might be able to join this trial: - People aged 5 years or older. - People who have been diagnosed with Charcot-Marie-Tooth (CMT) disease, a hereditary nerve condition, or healthy people who can serve as a comparison group. - Adults must sign a written consent form, unless a physical limitation prevents them from s...

**Who might be able to join this trial:** - People who have had ongoing, one-sided lower back and leg nerve pain (radiating from the lower spine) lasting more than 3 months - People between the ages of 35 and 60 years old - Both men and women are eligible - People who have a disc herniation or protrusion at the L4-L5 o...

Who might be able to join this trial: - People who are adults (18 years of age or older) - People who have had a motor cortical stimulation device surgically implanted to treat long-term nerve pain that has not responded to other treatments - People who have a post-surgery scan available from after their implant proced...

Who might be able to join this trial: **Main participant groups (High-Risk and Low-Risk Cohorts):** - People aged 3 years or older. - People who have been diagnosed with Neurofibromatosis Type 1 (NF1), either through clinical assessment or genetic testing. - People with a diagnosis of mosaic or segmental NF1 (a form w...

**Who might be able to join this trial:** - People who have a diabetic foot ulcer or a venous leg ulcer that has not reduced in size by at least 50% after 4 weeks of standard treatments, such as wound cleaning, removal of dead tissue, infection control, blood sugar management (for diabetic foot ulcers), compression the...

**Who might be able to join this trial:** - People aged 20 to 90 years old - People who are able to give informed consent to take part in the study - People who have neuropathic pain and/or abnormal sensory symptoms (such as numbness, tingling, or unusual sensations) caused by either a peripheral nerve condition (confi...

Who might be able to join this trial: - Adults aged 18 or older who have been admitted to Siriraj Hospital with signs and symptoms of carpal tunnel disease - People whose carpal tunnel disease has been confirmed through nerve conduction and muscle electrical activity tests - People who are able to communicate in Thai...

Who might be able to join this trial: - People who have had tingling, numbness, or pain in the hand (in the area controlled by the median nerve) that occurs at night, with certain positions, or with movement, lasting for more than 3 months. - People whose carpal tunnel syndrome has been confirmed as mild, moderate, or...

**Who might be able to join this trial:** - Adults aged 18 or older - People experiencing pain on one side of the body that shoots or radiates down into a leg (with or without lower back pain), following the path of specific nerve routes - People whose symptoms match what is visible on an MRI scan - People who have had...

Who might be able to join this trial: - People who have been diagnosed with type 2 diabetes and/or severe obesity (a body mass index, or BMI, over 40) - People who are over 18 years old Who may not be able to join: - People who do not speak English, Danish, or Greenlandic Important: Always verify eligibility with the...

**Who might be able to join this trial:** - People aged 18 to 70 years old - People who have been diagnosed (through tissue or cell testing) with a soft tissue sarcoma that cannot be surgically removed, has spread locally, or has spread to other parts of the body — including specific types such as leiomyosarcoma, lipo...

**Who might be able to join this trial:** - People who speak English - People aged 21 years or older - People who have had an active diabetic foot ulcer that required offloading (a treatment to relieve pressure from the foot) - People who are able to understand and agree to participate in the study - People who have ac...

Who might be able to join this trial: - People who are over 18 years old - People who have been diagnosed with diabetic peripheral neuropathy (nerve pain related to diabetes) that has not responded to gabapentin or pregabalin, as well as at least one other type of pain medication - People whose pain from diabetic nerve...

Who might be able to join this trial: - People who have been diagnosed with CIDP (Chronic Inflammatory Demyelinating Polyneuropathy) or possible CIDP, specifically the typical form, the mainly motor form, or the multifocal form (also called Lewis Sumner Syndrome), confirmed by a study review committee - People who have...

**Who might be able to join this trial:** - People aged 18 or older, of any gender - People who have been diagnosed with postherpetic neuralgia (long-lasting nerve pain after shingles) by a qualified doctor, and for whom peripheral nerve stimulation therapy has been recommended - People whose nerve-related pain has be...

Who might be able to join this trial: **Experimental group (people affected by cancer-related nerve symptoms):** - Adults aged 18 and older who have been diagnosed with a cancer that is not in the brain or spinal cord, received treatment for it, and are now experiencing nerve-related symptoms (such as numbness, tingli...

Who might be able to join this trial: - People who have been diagnosed with wild-type transthyretin amyloid cardiomyopathy (a heart condition caused by protein build-up), confirmed through genetic testing, a bone scan, and/or a heart tissue biopsy. - People who are currently taking water pills (loop diuretics) to manag...

**Who might be able to join this trial:** - People who have voluntarily agreed to take part in this clinical trial. - Men and women aged 19 years or older at the time of signing the consent form. - People who have been genetically diagnosed with CMT type 1A (CMT1A). - People whose CMT symptoms fall within a specific r...

Who might be able to join this trial: - People who have had an incomplete spinal cord injury (meaning some function remains below the injury site) affecting the lower back, legs, or lower neck area (specifically C5 to C7 levels) - People who experience nerve pain every day at a level of at least 4 out of 10 in severity...

**Who might be able to join this trial:** - People who have been diagnosed with type 2 diabetes (based on American Diabetes Association 2021 guidelines) - People of any sex - People between 18 and 75 years of age - People classified as moderate to high risk for developing diabetic foot problems, according to a specific...

Who might be able to join this trial: - People being treated with Koselugo (Selumetinib) in South Korea, where this treatment has been officially approved for use. - A signed and dated consent form must be provided by the patient or their legal representative before joining. Who may not be able to join: - The exclusio...

**Who might be able to join this trial:** - People aged between 18 and 70 years old - People whose MRI scan shows a compressed nerve root in the neck - People with neck pain on one or both sides rated 3 or higher on a 0–10 pain scale, or neck pain with tingling/numbness or arm pain rated 3 or higher on a 0–10 pain scal...

**Who might be able to join this trial:** - You are at least 20 years old - You (or your legal representative) are able to understand what the study involves and are willing to sign a consent form - You are willing to follow the wound care routine for the whole study and attend all required visits - You have been diag...

**Who might be able to join this trial:** - People who are 21 years of age or older at the time of surgery. - People who have already had a specific spinal disc implant called the Synergy Disc placed in their neck, or for whom a doctor has already decided this implant will be used. - People who are fully grown (skeleta...

**Who might be able to join this trial:** - You are able to read and understand English, can sign a consent form, and are willing to follow the study requirements - You are generally able to carry out daily activities (your doctor rates your physical ability as fairly good to fully active) - You are willing to travel...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have a confirmed HIV diagnosis and have been on a stable HIV treatment (antiretroviral) regimen for at least 90 days - People who have had ongoing pain related to HIV for at least 90 days - People who have either been on a stable pain mana...

**Who might be able to join this trial:** - Adults aged 18 or older - People with a performance status rated 0 to 2 (meaning able to carry out daily activities, with at most some limitations) (confirm with trial site) - Women who have been diagnosed with breast cancer that is localised or locally advanced (has not spre...

Who might be able to join this trial: - People aged between 18 and 65 years old. - People who have been diagnosed with mild to moderate carpal tunnel syndrome, confirmed through nerve conduction or electrical tests. - People who have been experiencing symptoms for at least 3 months. Who may not be able to join: - Peop...

Who might be able to join this trial: - The person must be 18 years of age or older at the time of joining the trial. - The person must have a pain score of at least 60 out of 100 on a standard pain scale at the start of the trial. - The person must have long-term, hard-to-treat pain in the trunk or limbs related to th...

**Who might be able to join this trial:** *Fracture Group:* - People between 18 and 85 years old - People who have a single ankle fracture (of a specific type, known as AO/OTA types A–C) that is being treated with surgery - People whose other injuries (outside of the broken ankle) are considered minor in severity - Pe...

Who might be able to join this trial: - People aged 50 to 85 years old who are able to walk and move around - People who are willing and able to give their consent to participate and follow the study requirements - People who have a diabetic foot ulcer (an open wound on the foot caused by diabetes) that goes at least t...

Who might be able to join this trial: - Adults who are 18 years of age or older - People who are willing to give their formal agreement to participate in the trial - People who are scheduled to receive a chemotherapy drug called paclitaxel either before or after their main cancer treatment - People who are able to spea...

**Who might be able to join this trial:** - People aged 18 or older. - People who are willing to sign a written consent form to take part in the study. - People who are able to arrange their own transport to the study site every day for the full length of the study. - People who have had a spinal cord injury (SCI) — e...

**Who might be able to join this trial:** - You are between 40 and 70 years old - You have symptoms that match carpal tunnel syndrome, such as numbness, tingling, weakness, or pain in your fingers, symptoms that get worse with gripping or at night, and signs of nerve problems in your hand detected during a physical exa...

Who might be able to join this trial: - People who are older than 18 years of age - People who have been diagnosed with herpes zoster neuralgia (nerve pain caused by shingles) - People who are willing and able to sign a consent form agreeing to take part in the trial Who may not be able to join: - People who are unabl...

Who might be able to join this trial: - People who are 18 years of age or older. - People who have been diagnosed with type 1 or type 2 diabetes. - People whose wound (after being cleaned) measures between 1.0 cm² and 25.0 cm², as measured using a specific imaging device called MolecuLight®. - People whose wound has be...

Who might be able to join this trial: - People who are between 40 and 65 years old. - People who are female and have had a unilateral modified radical mastectomy (removal of one breast along with surrounding tissue). - People experiencing moderate or severe pain described as burning, tingling, numbness, or electric-lik...

Who might be able to join this trial: - You have been diagnosed with mild to moderate diabetic neuropathy, with a score between 2 and 7 out of 10 on a standard nerve symptom assessment called the MNSI - You are currently experiencing symptoms of diabetic neuropathy - You are between 18 and 79 years old - You are able a...

Who might be able to join this trial: - People aged 19 years or older - People who have a fracture at the lower end of one wrist (on one side only, with no break in the skin) confirmed by X-ray - People whose fracture happened within the last 21 days - People whose fracture is being treated with surgery that uses a met...

**Who might be able to join this trial:** - You have been diagnosed with cervical spondylotic radiculopathy (a type of neck condition caused by nerve compression) and have no other related complications - You are between 18 and 65 years old (any gender) - You have not received any treatment for your neck condition in t...

Who might be able to join this trial: - People who are willing and able to give written consent to take part in the study - People who have a confirmed diagnosis of amyloid transthyretin (ATTR) amyloidosis (a condition where a specific protein builds up and damages organs) - People who are 18 years of age or older at t...

Who might be able to join this trial: - People who have been clinically diagnosed with hereditary spastic paraplegia (a condition affecting movement and muscle stiffness in the legs). - People whose condition has been specifically identified as Spastic Paraplegia Type 56 (SPG56), confirmed by genetic testing showing a...

Who might be able to join this trial: - People who are 21 years of age or older - People whose diabetic foot ulcer has fully healed within the past twelve months - People who are able to walk on their own (using a cane is acceptable) Who may not be able to join: - People who currently have an active diabetic foot ulce...

Who might be able to join this trial: - People who are receiving chemotherapy to treat a solid tumour (a type of cancer that forms a lump or growth in the body) - People who are over 18 years of age Who may not be able to join: - People who are 18 years of age or younger - People who already have nerve damage (neuropa...

**Who might be able to join this trial:** - People aged 18 years or older - People who have been diagnosed with uterine, ovarian, fallopian tube, primary peritoneal, cervical, or vulvar cancer - People who are planned to receive, or have recently completed, 6 to 9 cycles of a chemotherapy regimen containing paclitaxel...

Who might be able to join this trial: - Adults who are active and moving around ("kinetic"), with a cancer diagnosis, and who are expected to live with their cancer for more than one year - People who are receiving chemotherapy using platinum and paclitaxel together for the first time - People who are willing to take p...

**Who might be able to join this trial:** - People aged 18 or older - People whose doctor has decided to start them on a first-line treatment called TDC (a combination treatment for lung cancer) in line with current approved prescribing guidelines - People who have been confirmed, through a tissue or cell sample, to h...

Who might be able to join this trial: - People between 20 and 40 years old - People who have received a medical diagnosis of moderate to severe carpal tunnel syndrome (a condition causing pain, numbness, or tingling in the hand and wrist) - People who have been experiencing carpal tunnel syndrome symptoms for at least...

Who might be able to join this trial: **For people with cancer:** - Adults aged 18 or over - People diagnosed with breast, gynaecological, colorectal, or lung cancer who are due to undergo one or more cancer treatments (such as chemotherapy, surgery, hormone therapy, radiotherapy, or targeted therapy) - People who are...

**Who might be able to join this trial:** - People between 30 and 55 years old - People who have Type 2 diabetes - People who were diagnosed with Type 2 diabetes within the last 1 year, based on World Health Organization 1999 diagnosis standards **Who may not be able to join:** - People who have known conditions that...

**Who might be able to join this trial:** - People who are 18 years of age or older - People with a diabetic foot ulcer must have been diagnosed with Type 1 or Type 2 diabetes - People whose wound is located on the foot or ankle (for diabetic foot ulcers) or on the leg (for venous leg ulcers) - People whose wound meas...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been diagnosed with Neurofibromatosis Type 1 (NF1), a genetic condition that causes tumors to grow on nerve tissue, based on specific updated diagnostic guidelines from 2021 - People who have a history of plexiform neurofibromas (a...

**Who might be able to join this trial:** - People who have been diagnosed with cancer that has been confirmed through laboratory testing of tissue samples - People who have completed at least one round of chemotherapy treatment using a drug called albumin-bound paclitaxel - People whose blood, liver, and kidney functi...

Who might be able to join this trial: - People who are over 18 years old - People who have been diagnosed with diabetes - People who are willing to take part in the study voluntarily - People who have good communication skills and are able to take part in training sessions Who may not be able to join: - People who are...

Who might be able to join this trial: - People between the ages of 20 and 50 years old, of any gender. - People who have had ongoing pain in the buttock and hip area for more than 3 months, rated at least 3 out of 10 on a pain scale. - People whose piriformis muscle (a muscle deep in the buttock) is found to be shorten...

Who might be able to join this trial: - People between 18 and 35 years old - Male cricket players - People who have already been diagnosed with sciatica and referred by an orthopaedic doctor - People who have had low back pain for at least 3 months before joining the trial - People who experience pain during a specific...

Who might be able to join this trial: - People who have had typical carpal tunnel syndrome symptoms (such as hand numbness, tingling, or pain) for longer than 3 months - People whose carpal tunnel syndrome has been confirmed through a nerve conduction test (called an EMG) - People who are male or female and are over 18...

**Who might be able to join this trial:** - People who have been diagnosed with Neurofibromatosis Type 1 (NF1) based on the 2021 updated diagnosis guidelines. - People who have one or more plexiform neurofibromas (a type of nerve tumour linked to NF1) that are either growing over time, or causing serious problems such...

**Who might be able to join this trial:** - People who have painful, treatment-resistant nerve damage in the hands, feet, or other distant parts of the limbs — ideally caused by an injury or surgery — that has been confirmed by a nerve and muscle electrical test (called an EMG) - People whose pain has not responded to...

**Who might be able to join this trial:** - You must be eligible for DEERS (the Defense Enrollment Eligibility Reporting System, used for U.S. military-related healthcare) - You must be between 18 and 65 years old - You must have pain and tingling/numbness in the area of the hand supplied by the median nerve (typically...

**Who might be able to join this trial:** - You must be 18 years of age or older. - You must have been diagnosed with type 1 or type 2 diabetes. - You must have a foot ulcer that measures between 1.0 cm² and 5.0 cm² in size after any wound cleaning has been done. - Your foot ulcer must have been present for at least 4...

Who might be able to join this trial: - People who have diabetes and have a foot condition that required amputation. - People who have had a toe, ankle, or foot amputation. - People who are 18 years of age or older. Who may not be able to join: - People who are under 18 years of age. - People whose amputation was caus...

**Who might be able to join this trial:** - People aged 16 or older, of any gender - People who have been diagnosed with NF2-associated nerve sheath tumors, either using the revised 2022 diagnostic criteria or confirmed through laboratory tissue analysis - People who either had surgery that did not fully remove the tu...

**Who might be able to join this trial:** - People who are 21 years of age or older. - People who have been diagnosed with Type 1 or Type 2 diabetes. - People whose wound (ulcer) measures between 1.0 cm² and 5.0 cm² after being cleaned out by a medical professional. - People whose wound has been present for at least 4...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been diagnosed with type 1 or type 2 diabetes - People whose foot ulcer measures between 0.7 cm² and 20.0 cm² after being cleaned and prepared by a medical professional - People whose foot ulcer has been present for a...

Who might be able to join this trial: - People aged 18 years or older - People who have been diagnosed with type 2 diabetes, based on World Health Organization (WHO) diagnostic standards - People who have been diagnosed with diabetic polyneuropathy (nerve damage related to diabetes), confirmed through two specific nerv...

Who might be able to join this trial: - You have been diagnosed by a doctor with carpal tunnel syndrome (a condition where a nerve in the wrist becomes compressed, causing hand and wrist problems). - You are between 30 and 55 years old. - You are female. - You have tested positive on two specific wrist physical tests (...

Who might be able to join this trial: - You are an adult who has been diagnosed with diabetes for at least 1 year - You own and use a mobile phone Who may not be able to join: - You have been diagnosed with a condition that affects memory, thinking, or understanding (cognitive impairment) Important: Always verify eli...

Who might be able to join this trial: - Adults aged 18 years or older. - People who have been diagnosed with pudendal and inferior cluneal entrapment neuralgia (a type of chronic nerve pain in the pelvic and lower buttock area) with 5 out of 5 positive "Nantes criteria" (a specific set of diagnostic markers used by doc...

**Who might be able to join this trial:** - Adults between the ages of 18 and 80 who have been diagnosed with occipital neuralgia or migraines that are mainly felt in the back of the head. - People whose occipital neuralgia diagnosis meets standard medical criteria, meaning they experience sharp, stabbing pain at the...

**Who might be able to join this trial:** - Adults between 18 and 85 years old, of any gender - People who have been diagnosed with type 1 or type 2 diabetes for at least 12 months before the first study visit - People who have a diabetic foot ulcer that is classified as grade 1 or 2 on a standard wound severity scale...

**Who might be able to join this trial:** - People aged 18 to 65 years old who have been formally diagnosed with a neuropathic pain condition (nerve pain), such as diabetic nerve pain, trigeminal neuralgia, or pain following a stroke - People who have already tried standard treatments for their nerve pain — such as me...

**Who might be able to join this trial:** - The person has signed a consent form agreeing to take part in the study - The person is aged 18 to 80 years old (male or female) - The person is scheduled to be treated with a specific wound care product called a borate-based bioactive glass fiber matrix (BBGFM) for their di...

**Who might be able to join this trial:** - People aged between 18 and 65 years old - People who have been clinically diagnosed with Carpal Tunnel Syndrome (a condition causing pain, numbness, or tingling in the hand and wrist) - People whose Carpal Tunnel Syndrome has been confirmed as mild or moderate through a nerve...

**Who might be able to join this trial:** - You have at least two unusual-looking moles (atypical nevi) that are 4mm or wider (roughly the size of a pencil eraser or larger) - You have a documented diagnosis of melanoma (a type of skin cancer) - You are 18 years of age or older, and if you are a woman who could become...

Who might be able to join this trial: - Adults aged 18 to 99 who were admitted to a general intensive care unit between January 2012 and September 2024 with a diagnosis of Guillain-Barré syndrome, needed a breathing machine (mechanical ventilation), and had a tracheostomy (a surgical opening in the throat to help with...

**Who might be able to join this trial:** - People aged between 18 and 80 years old. - People who have been diagnosed with nerve pain (neuropathic pain) in both feet caused by a widespread nerve condition affecting the legs and feet, where the cause may be a known illness, exposure to a toxic substance, or unknown. -...

**Who might be able to join this trial:** - People who have been diagnosed with Guillain-Barré Syndrome (GBS) according to recognised international diagnostic guidelines, or people diagnosed with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) according to European neurological society guidelines. - People age...

**Who might be able to join this trial:** - People who have voluntarily agreed to take part and have signed an approved consent form. - People aged between 18 and 80 years old. - People who have a severe nerve cut (classified as Sunderland's 4th or 5th degree) in the arm or hand that has caused loss of nerve function a...

**Who might be able to join this trial:** - People who have been diagnosed with either Type 1 or Type 2 diabetes - People whose HbA1c (a blood test that measures average blood sugar levels over about 3 months) is at or below 9% - People who have had pain in both legs or feet caused by diabetic nerve damage (a condition...

Who might be able to join this trial: - You are aged 18 or older and are the caregiver of a baby who is 6 months old or younger - Your baby has been diagnosed with a birth-related brachial plexus injury (a nerve injury affecting the arm that occurred at birth), confirmed by the specialist clinic team at the first visit...

Who might be able to join this trial: - People who weigh at least 45 kilograms (about 99 pounds). - People whose body mass index (a measure of body weight relative to height) falls between 18.0 and just under 40.0. - People who have been diagnosed with type 1 or type 2 diabetes, have a blood sugar control reading (HbA1...

Who might be able to join this trial: - People who have been diagnosed with carpal tunnel syndrome (CTS), a condition where a nerve in the wrist is compressed, causing pain or numbness in the hand - People whose pain fits a specific pattern called "nociplastic pain," which refers to pain that is not explained by tissue...

Who might be able to join this trial: - People who are 18 years of age or older - People who had cataract surgery at HUS (the hospital where this trial is based) between January 2022 and January 2024 - People who did not previously object to their medical data being used for scientific research - People who had the rel...

**Who might be able to join this trial:** - You are a woman over 18 years old - You can read and speak English - You have been diagnosed with pudendal neuralgia, or you have long-term pelvic pain felt in the area connected to the pudendal nerve (a nerve in the pelvic region), lasting 3 months or more - Your pain or dis...

Who might be able to join this trial: - People who have been diagnosed with lumbar radiculopathy (nerve pain in the lower back caused by a slipped or herniated disc), where their symptoms match what is shown on their lower back MRI scan - People between 18 and 65 years of age - People who have agreed to take part in th...

Who might be able to join this trial: - People who have been diagnosed with cervical radiculopathy (a condition involving nerve irritation in the neck). - People between the ages of 20 and 60 years old. - People experiencing pain that radiates down one arm along the path of the median nerve. - People who test positive...

Who might be able to join this trial: - People between the ages of 18 and 65. - People who have been diagnosed with mild to moderate carpal tunnel syndrome, confirmed through nerve conduction (electrophysiological) testing. - People who have already received either an ultrasound-guided corticosteroid injection or paraf...

Who might be able to join this trial: - People who have signed a written consent form agreeing to take part in the trial. - People who have been confirmed through a tissue or cell sample to have a specific type of solid tumour cancer that has spread to other parts of the body, has come back, or is advanced in the local...

**Who might be able to join this trial:** - People (living or deceased) who have been diagnosed with a condition called SPLIS, confirmed by genetic testing showing changes in a gene called SGPL1 - People who have changes in both copies of the SGPL1 gene and also show at least one sign of SPLIS, such as kidney disease...

**Who might be able to join this trial:** - You have been diagnosed with a hereditary condition called ATTRv-PN (a nerve disease caused by a faulty TTR gene that leads to abnormal protein build-up in the body) - You are able to carry out most normal daily activities — meaning your overall health and physical ability me...

**Who might be able to join this trial:** - People who have had a traumatic spinal cord injury at or above the T1 level (roughly the upper back or neck), either within the last 6 months (and considered medically stable) or more than 6 months ago, with any level of impairment severity. - People who have had a periphera...

**Who might be able to join this trial:** - People aged between 35 and 50 years old - Both men and women are eligible - People who have mild to moderate neck disability, as measured by a standard scoring tool called the Neck Disability Index - People who have had nerve pain on one side of the neck for more than 6 month...

Who might be able to join this trial: - People who have been diagnosed with sciatica, confirmed by a physical examination and imaging (such as an MRI or X-ray) - People whose sciatica pain occurs on one side of the body only - People who have been experiencing sciatica symptoms for at least 3 months - People whose pain...

**Who might be able to join this trial:** - People who have had an arm amputated at the forearm or upper arm level, or a leg amputated at the lower leg or thigh level. - People aged between 18 and 65 years. - People whose amputation took place at least 6 months ago. - People who have ongoing, persistent chronic pain ra...

**Who might be able to join this trial:** - Adults aged 18 or older - People who have previously received chemotherapy for any type of cancer - People who have been diagnosed with numbness or tingling caused by chemotherapy-related nerve damage, where the symptoms are classified as moderate to severe (Grade 2 or higher...

**Who might be able to join this trial:** **Group 1 – People who have not yet been treated:** - People who have been diagnosed with CIDP (a nerve condition) according to recognised international guidelines - People who have not yet received any treatment for CIDP - Men and women between 18 and 80 years of age - People...

**Who might be able to join this trial:** - People aged between 18 and 75 years old - People who have been diagnosed by a doctor as having a spinal cord injury for at least 3 months - People who have had nerve pain (a burning, shooting, or stabbing type of pain caused by nerve damage) for at least 3 months - People who...

Who might be able to join this trial: - People who have been diagnosed with Hereditary Spastic Paraplegia (HSP), either through genetic testing or based on clinical symptoms. - People who are older than 4 years and younger than 70 years of age. - People whose thigh bone (femur) measures more than 23 cm in length (confi...

**Who might be able to join this trial:** - You are between 18 and 65 years old - A pain specialist has diagnosed you with long-lasting nerve pain (chronic neuropathic pain) - Your nerve pain is rated as moderate to severe based on a standard patient questionnaire - You have already tried at least two medications recom...

Who might be able to join this trial: - Women who have been diagnosed with a specific type of breast cancer called invasive ductal carcinoma, at stages I, II, or III. - Women between the ages of 30 and 65. - Women who are 3 to 6 months past their breast cancer diagnosis. - Women who have finished chemotherapy and are i...

Who might be able to join this trial: - Adults who have been diagnosed with Hereditary Spastic Paraplegia. - People who have some loss of function in their legs that affects how they walk, such as muscle weakness, stiffness, or balance problems. - People who are able to walk without needing another person to physically...

**Who might be able to join this trial:** - The person is willing and able to understand and follow all trial procedures and requirements, as judged by the trial investigator. - The person has provided written, signed, and dated consent before any trial procedures begin. - A neurologist specialising in neuromuscular d...

**Who might be able to join this trial:** - Adults aged 18 or older, of any gender. - People who are willing and able to give written consent to participate and allow access to their personal health information. - People who have a confirmed diagnosis of CIDP (Chronic Inflammatory Demyelinating Polyneuropathy) that me...

Who might be able to join this trial: - People who have been diagnosed with piriformis syndrome (a condition causing buttock and hip pain related to the piriformis muscle) - Women between the ages of 25 and 50 years old - People who have been experiencing pain for at least 2 months Who may not be able to join: - Peopl...

Who might be able to join this trial: - People rated as ASA physical status class 1, 2, or 3, meaning they are in generally good to moderate health (confirm with trial site) - People with a body mass index (BMI) between 18.5 and 25, which is considered a normal, healthy weight range - People who can lie flat on their b...

Who might be able to join this trial: - People who are over 18 years old - People who have normal color vision - People who experience numbness, tingling, weakness, or pain in their hands, wrists, or fingers - People who have a positive result on a specific wrist test called Phalen's test (confirm with trial site) - Pe...

Who might be able to join this trial: - You must be willing to sign a consent form agreeing to take part in the study - You must be 18 years old or older at the time of signing the consent form - You must have been diagnosed with a solid tumour (such as breast cancer or lung cancer) - You must be scheduled to receive a...

**Who might be able to join this trial:** - People aged 18 years or older - People scheduled for a major planned (non-emergency) surgery, such as heart, chest, or abdominal surgery - People expected to stay in the intensive care unit (ICU) for more than one day after their surgery - Healthy people of a similar age who...

**Who might be able to join this trial:** - People aged 18 or older, of any gender, who are expected to live for at least 5 more months - People who have a confirmed diagnosis of a head or neck tumour that was treated with radiotherapy at least 6 months before the screening period - People who have had ongoing nerve p...

**Who might be able to join this trial:** - People who are 18 years of age or older. - People who have been diagnosed with Type 1 or Type 2 diabetes. - People who have a diabetic foot wound (ulcer) that, after cleaning, measures between 1.0 cm² and 10.0 cm² in size at the time of joining the trial. - People whose foot...

**Who might be able to join this trial:** - People aged 18 or older - People who have been diagnosed with uterine (womb), ovarian, or cervical cancer - People whose physical functioning is rated at a certain level by their doctor (known as ECOG score 0–2, meaning able to carry out at least some daily activities — confi...

**Who might be able to join this trial:** - People who are between 18 and 80 years old at the time of joining. - People who have been diagnosed with chronic pain in the knee, arm, or shoulder, rated at least 5 out of 10 on a pain scale. - People whose pain is related to nerve damage or nerve problems, such as pain fro...

Who might be able to join this trial: - People who have been diagnosed with breast cancer confirmed by a pathology report. - People whose physical functioning is rated at 0 or 1 on a standard scale used to measure how well a person can carry out daily activities (confirm with trial site). - People between the ages of 1...

Who might be able to join this trial: - Adults aged 18 years or older - People who have been diagnosed with advanced melanoma (a type of skin cancer) at stage III or stage IV that cannot be surgically removed, including melanoma that started in the skin, in mucous membranes (such as the mouth or nose), or from an unkno...

Who might be able to join this trial: - People who have been assessed by their doctor as a suitable candidate for spinal cord stimulation and are already scheduled to undergo a trial phase using the Evoke spinal cord stimulation system - People who rate their pain at least 5 out of 10 on a standard pain scale at the st...

Who might be able to join this trial: - Children and teenagers who have been diagnosed with sciatic nerve damage caused by an injection that was given incorrectly into the muscle. - Children between the ages of 3 and 19 years old. - Children whose parents or guardians have given their consent for the child to take part...

Who might be able to join this trial: - People who have been clinically diagnosed with weakness or paralysis in two or four limbs, caused by a problem with the peripheral nervous system, confirmed by nerve and muscle electrical testing (ENG/EMG) - People who were living independently before becoming critically ill Who...

**Who might be able to join this trial:** - People aged 40 years or older, of any gender - People who are able to understand and sign a consent form before any study activities begin - Women who are either surgically unable to become pregnant (through removal of the uterus, fallopian tubes, or ovaries) or who have bee...

Who might be able to join this trial: - People who have been clinically diagnosed with Charcot-Marie-Tooth disease (CMT), or healthy adults who have no history of the condition (as a comparison group) - People with CMT whose diagnosis has been confirmed through genetic testing - People who are able to complete the tria...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with pudendal neuralgia and/or inferior cluneal neuralgia (nerve pain in the pelvic or lower buttock area) where standard medical treatments have not worked - People who have read the information provided ab...

**Who might be able to join this trial:** - People who are 18 years of age or older at the time of signing the consent form - People who weigh 150 kilograms or less - People who have been diagnosed with typical CIDP (a nerve condition) by a neurologist who specialises in nerve and muscle diseases, confirmed using reco...

Who might be able to join this trial: - People who are older than 18 years of age - People who have been diagnosed with cardiac amyloidosis (a condition where abnormal proteins build up in the heart) confirmed through an MRI or a nuclear imaging scan called scintigraphy - People who are physically able to complete a ca...

**Who might be able to join this trial:** - People who agree to take part in the related OzoParQT clinical trial and are willing to provide stool samples for gut bacteria analysis. - Adults aged 18 or older. - People who have previously received chemotherapy for any type of cancer. - People who have been diagnosed wit...

**Who might be able to join this trial:** - People who have had ongoing one-sided neck pain with nerve symptoms (such as pain, numbness, or tingling radiating from the neck) lasting between 3 months and 1 year - People aged between 40 and 55 years, of any sex - People with a body mass index (BMI) under 30 kg/m² (a meas...

**Who might be able to join this trial:** *Healthy volunteers:* - People who have signed a written consent form agreeing to take part - People who have no physical or mental health conditions (see exclusion criteria below for details) - People who are able and willing to follow the study's requirements throughout the...

**Who might be able to join this trial:** - Men and women aged 18 to 85 years old with a body mass index (a measure of body weight relative to height) either below 25 or at 30 or above - People who have low back or buttock pain that travels down one or both legs past the knee (sciatica) and has lasted for at least 3 mo...

Who might be able to join this trial: - You are between 18 and 80 years old. - You have been diagnosed with an acute or subacute neuromuscular disease (a condition affecting the nerves and muscles that came on recently), such as Guillain-Barré Syndrome (GBS), or muscle/nerve damage related to critical illness. - Your s...

Who might be able to join this trial: **For people with diabetic foot ulcers (DFU):** - People who are 21 years of age or older. - People who have been diagnosed with type 1 or type 2 diabetes. - People whose target wound measures between 1.0 cm² and 20.0 cm² after being cleaned and prepared by a medical professional....

**Who might be able to join this trial:** - Adults aged 18 or older - People being treated for any type of cancer at the Montpellier Cancer Institute that requires chemotherapy - People experiencing significant nerve pain, defined by a specific clinical scoring tool called the DN4 reaching a score of 4 or higher (conf...

**Who might be able to join this trial:** - People who have been diagnosed with hereditary spastic paraplegia (HSP) based on both their symptoms and genetic testing - People between the ages of 14 and 70 years old - People who have significant muscle stiffness in the legs, specifically where at least 2 joints are rated...

**Who might be able to join this trial:** - People aged between 18 and 80 years old - People who have freely agreed to take part in the study - People who have been diagnosed with hereditary CMT neuropathy (a nerve condition confirmed through genetic testing) - People who have been diagnosed with an acquired demyelinat...

**Who might be able to join this trial:** - People aged between 18 and 75 years who have been diagnosed with chronic lumbar radiculopathy (long-term nerve pain originating in the lower back) based on medical history, physical examination, imaging scans, and nerve conduction tests - People who are attending an outpatien...

Who might be able to join this trial: - People aged 18 or older, of any gender. - People whose nerve pain has been present and is linked to chemotherapy treatment involving platinum-based drugs, taxane-based drugs, or both. - People who have completed a chemotherapy treatment that included taxane or platinum drugs, and...

**Who might be able to join this trial:** - People who are willing and able to take part in all trial activities and who can sign and date a consent form before any trial procedures begin - People aged 18 to 75 years, of any gender - People who have been diagnosed with a diabetic ulcer (wound related to diabetes) loca...

**Who might be able to join this trial:** - People who have been diagnosed with Stage III colorectal cancer, confirmed through a tissue biopsy or similar laboratory test. - People who are scheduled to receive a specific chemotherapy regimen called modified FOLFOX-6. - People who have no medical reasons preventing them...

**Who might be able to join this trial:** - You are 18 years of age or older, from any country. - You have been diagnosed with a malignant tumor (cancer). - You are experiencing nerve-related symptoms caused by chemotherapy — such as changed sensations, pain, or other nerve problems — that are rated as moderate to seve...

**Who might be able to join this trial:** - Children between 6 months and 18 years old who have a severe neurological impairment (from any cause) and are experiencing pain and irritability that cannot be explained - Children whose thinking or communication difficulties make it impossible to determine where their pain...

Who might be able to join this trial: - People who are 18 years of age or older - People who have given their consent to take part in the study - People who are covered by a social security or health insurance plan - People who have been diagnosed with pudendal neuralgia (a type of chronic pelvic nerve pain), confirmed...

**Who might be able to join this trial:** - You have been formally diagnosed with a long-term neuromuscular disease (such as ALS, CIDP, or CMT — conditions that affect the nerves and muscles) - You are able to walk on your own or with some help (such as a walking aid or another person) - You are able to understand and...

**Who might be able to join this trial:** - People aged 18 to 65 (male or female) who have been seen at Ahi Evran University's Physical Medicine and Rehabilitation clinic and have been diagnosed with carpal tunnel syndrome through both a clinical examination and a nerve conduction test (EMG) - People who are able to un...

**Who might be able to join this trial:** - People who are able to understand the study, agree to take part voluntarily in writing, and are willing to follow all study requirements such as scheduled visits, tests, and procedures. - People who are 18 years of age or older. - People who have been diagnosed with advanced...

**Who might be able to join this trial:** - You are 18 years of age or older - You have had ongoing pain for more than 3 months after a shingles (herpes zoster) skin rash has healed - Your average pain level is rated at least 4 out of 10 on a pain scale (where 0 means no pain and 10 means the worst pain imaginable) - Y...

**Who might be able to join this trial:** - You have breast cancer and are receiving treatment at the Oncology Department at Sahlgrenska University Hospital. - You have previously been treated with a type of chemotherapy called taxanes. - You are 18 years old or older. - You are able to understand spoken and written Sw...

Who might be able to join this trial: - People who are 18 years of age or older - People who were diagnosed with TTR amyloidosis (a specific type of protein build-up disease) during a hospital stay in the internal medicine department at HUS (Strasbourg University Hospitals) between 1 January 2013 and 31 December 2023...

Who might be able to join this trial: - People who are having traumatic amputation of one or more fingers or toes treated at MGB (Massachusetts General Brigham) - People who speak English Who may not be able to join: - People who are having a planned revision amputation or an amputation that is not the result of a tra...

**Who might be able to join this trial:** - Adults aged 18 years or older - People who have a confirmed diagnosis of either Type 1 or Type 2 diabetes - People who currently have a diabetic foot ulcer that is being actively treated by a wound care team - People whose foot ulcer size meets the study's specific size requi...

**Who might be able to join this trial:** - People who have been diagnosed with CIDP (a nerve condition causing weakness and numbness) according to specific international medical guidelines from 2021 - People who have the typical form of CIDP, or one of these specific variants: motor CIDP, multifocal CIDP (also called...

Who might be able to join this trial: - People who have been diagnosed with stage 4 or 5 chronic kidney disease, or who have type 1 or type 2 diabetes (or both) - People who are able to walk at least 20 metres - People with a body mass index (a measure of body weight relative to height) below 35 Who may not be able to...