Phase 1 Myasthenia Gravis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For Multiple Sclerosis (MS):

• You have been diagnosed with MS (any form, including relapsing or progressive) using recognised medical guidelines (2017 McDonald criteria)
• For relapsing forms of MS: your MS has continued to be active despite being on a strong MS treatment, OR you have been unable to tolerate at least 2 MS treatments due to side effects
• For relapsing forms of MS: your level of disability falls within a specific range on a standard MS scale (EDSS score 0 to 5.5)
• For progressive forms of MS (non-active or primary progressive): your disease has continued to worsen over the past 12 months despite standard treatment
• For progressive forms of MS: you have had no relapses for at least 2 years
• For progressive forms of MS: a recent brain scan showed no signs of active inflammation (no gadolinium-enhancing lesions)
• For progressive forms of MS: your disability level falls within a specific range and you are still able to walk (EDSS 3 to 6.5)

For Myasthenia Gravis (MG):

• You have test results confirming specific antibodies linked to MG (against AChR, MuSK, or LRP4)
• Your MG causes generalised muscle weakness (not just eye symptoms), classified at a moderate to severe level (MGFA class II–IV)
• Your MG symptoms significantly affect your daily life, as measured by specific scoring tools (MG-ADL score of 6 or more, QMG score of 10 or more)
• Your MG has not responded well enough to at least 2 different types of immune-suppressing treatments
• If you have had thymus gland surgery, it must have been completed at least 12 months before joining the trial
• You must be willing to use contraception methods specified by the trial, if this applies to you

For Chronic Inflammatory Demyelinating Polyneuropathy (CIDP):

• You have a confirmed or probable diagnosis of CIDP (relapsing or progressive form) based on recognised medical guidelines
• Your CIDP symptoms are active enough to meet specific scoring thresholds (CDAS score of 3 or more, INCAT score of 3 or more)
• Your CIDP has not responded well enough to standard treatments, OR you have been unable to tolerate standard treatments due to side effects
• There is documented evidence that your condition improved with certain treatments in the past 2 years, or worsened when those treatments were reduced or stopped (except for certain subtypes of CIDP)

Who may not be able to join:

General (all conditions):

• You have a history of, or currently have, another condition affecting the brain or nerves that could affect thinking, strength, or cause weakness
• You have previously had a stem cell transplant (using your own or a donor's cells) or an organ transplant

For MS specifically:

• You are unable to complete certain physical tests within required time limits (a pegboard hand test in under 240 seconds and a 25-foot walk test in under 150 seconds) — applies to certain groups within the trial
• You have had a serious allergic reaction to gadolinium contrast dye (used in MRI scans)
• You have a kidney condition that would prevent you from safely receiving gadolinium dye
• You have a medical reason that means you cannot safely have a lumbar puncture (spinal tap)

For MG specifically:

• You are currently in a myasthenic crisis (severe sudden worsening) that has not been brought under control within 2 weeks before joining
• You have had thymus gland surgery within the past 12 months

For CIDP specifically:

• Your CIDP affects only your sense of feeling (pure sensory CIDP) or only one specific area of the body (focal CIDP)
• Your nerve problems are caused by something other than CIDP

Important: Always verify eligibility with the trial site directly before applying.

(Note: Additional eligibility criteria not listed here may also apply — the trial site can provide full details.)