Motor Neurone Disease

Who might be able to join this trial: - You must be between 18 and 80 years old at the start of the trial. - You must have been diagnosed with ALS, either the sporadic (no family history) or familial (runs in the family) type. - Your first ALS symptoms must have started within the last 24 months before joining the tria...

**Who might be able to join this trial:** - You have been diagnosed with ALS (either inherited or not inherited) within the last 24 months before the screening visit - Your lung breathing capacity (measured while sitting upright) is at least 60% of what would be expected for someone your age, height, and sex - You are...

**Who might be able to join this trial:** - People who have given their consent to participate, either in writing or verbally - People who have been diagnosed with ALS (also known as Motor Neurone Disease) that meets specific recognised diagnostic standards, supported by a nerve and muscle electrical test (EMG) review...

**Who might be able to join this trial:** - You have been officially diagnosed with ALS (a specific type confirmed by medical criteria called the Awaji Criteria) - You are between 18 and 74 years old at the time of joining the study - Your ALS symptoms first started less than 36 months (3 years) before the screening vi...

Who might be able to join this trial: - You are over 18 years old - Your doctor has recommended that you start using a non-invasive ventilation (breathing support) machine for the long term - You have a confirmed diagnosis of an underlying medical condition that requires this breathing support Who may not be able to j...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with ALS (Lou Gehrig's disease) using a specific set of diagnostic standards called the "Gold Coast Criteria" - Your ALS symptoms (such as limb weakness or swallowing/speech difficulties) started less than 24 months...

**Who might be able to join this trial:** - You have muscle weakness caused by ALS, and genetic testing has shown you carry a change in the SOD1 gene that is known or likely to cause ALS - Your lungs are working at 50% or more of the expected level for someone your age, sex, and height (measured while sitting or standi...

**Who might be able to join this trial:** - People diagnosed with ALS according to the Gold Coast Criteria (a standard set of diagnostic guidelines used by neurologists) - For the Phase 1b part of the trial: people whose first ALS symptoms began no more than 48 months (4 years) before the start of the study - For the...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease) based on specific recognised diagnostic guidelines - Your first ALS symptoms started no more than 2 years ago - You have low or no levels of a certain antibody in your blood that could interfere with the t...

**Who might be able to join this trial:** - You are able to agree to take part and give your consent to join the study. - You have weakness or loss of movement in both arms, or you have ALS (a condition affecting nerve and muscle control) with weakness in both arms. - Your condition causing the movement difficulty has...

**Who might be able to join this trial:** - You gave your agreement (written or verbal) to take part in the study - You completed the full 48 weeks of treatment in the related REFALS study - You are able to swallow capsules at the time you finished the 48-week REFALS study treatment **Who may not be able to join:** -...

Who might be able to join this trial: - You are between 18 and 80 years old (inclusive) - You have been diagnosed with familial or sporadic ALS, meeting certain diagnostic standards set by a global neurology organization (confirm with trial site if unsure which category applies to you) - Your first ALS symptom — such a...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease), and your first symptom appeared no more than 24 months ago at the time of your first screening visit. - Your ALS has been classified by a doctor as either "clinically definite" or "clinically probable" us...

Who might be able to join this trial: - You must be at least 18 years old - You may be eligible if you have been diagnosed with ALS or a related nerve and muscle degenerating disease (whether it runs in your family or appeared without a known family history) - You may be eligible if you are a healthy family member of s...

**Who might be able to join this trial:** - You have a family member who has been found to carry a gene linked to ALS (also known as Lou Gehrig's disease). - You currently have no symptoms that suggest you have ALS — you must be in good health at the time of joining. - Based on your family history, there is at least a...

Who might be able to join this trial: - Healthy volunteers are welcome to participate - Both men and women can apply Who may not be able to join: - People who are below the legal age of consent in their country or region Important: Always verify eligibility with the trial site directly before applying.

Who might be able to join this trial: - You must be a U.S. citizen aged 18 or older Who may not be able to join: - No specific exclusion criteria have been listed for this trial (confirm with trial site) Important: Always verify eligibility with the trial site directly before applying.

Who might be able to join this trial: **Healthy Adults:** - Adults aged 18 or older, male or female, who are in good general health based on their medical history - People who are willing and able to follow all study procedures and be available for the full duration of the study - People who are able to understand the...

**Who might be able to join this trial:** - You are between 21 and 75 years old (inclusive) - You are willing and able to read and sign a consent form that has been reviewed and approved by an ethics board - You have been diagnosed with ALS (also known as Lou Gehrig's disease) at any stage of certainty — possible, prob...

**Who might be able to join this trial:** - You must have a trusted person (such as a family member or close friend) who knows you well and can answer questions about how you are functioning day-to-day. - You must be able to read, understand, and speak English, as the memory and thinking tests are conducted in English...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also called Lou Gehrig's disease), confirmed by recognized medical criteria. - Your ALS may be inherited (runs in the family) or have appeared without a known family history. - Your ALS was diagnosed no more than 24 months (2 years) before th...

**Who might be able to join this trial:** This trial has five separate groups (called cohorts). People may be considered for one of the following groups: **Group A – Cognitively healthy, aged 40–65:** - People aged between 40 and 65 years old - People who a specialist doctor has assessed as having no signs of cogniti...

Who might be able to join this trial: - You are between 18 and 65 years old (male or female) - You have been diagnosed with Multiple Sclerosis (MS) according to a specific set of medical guidelines called the McDonald 2010 criteria - Your level of disability, measured on a standard MS scale (called the EDSS), falls bet...

**Who might be able to join this trial:** - People aged 18 or older - People who have been diagnosed by a neurologist with frontotemporal dementia, primary progressive aphasia, semantic dementia, motor neuron disorder, amyotrophic lateral sclerosis (ALS), progressive bulbar palsy, corticobasal syndrome, Huntington's di...

**Who might be able to join this trial:** - Adults who have been diagnosed with a neurodegenerative condition, such as mild cognitive impairment (MCI), Parkinson's disease, Alzheimer's disease, ALS, multiple sclerosis, Huntington's disease, traumatic brain injury, concussion, PTSD, Down Syndrome, or similar conditions...

Who might be able to join this trial: - People who have been assessed by a doctor as having suspected, possible, probable, or definite ALS (also known as Lou Gehrig's disease or Motor Neurone Disease) Who may not be able to join: - No exclusion criteria have been listed for this trial (confirm with trial site) Import...

**Who might be able to join this trial:** - You have been diagnosed with tetraplegia (paralysis of all four limbs), a brainstem stroke, ALS (Lou Gehrig's disease), or Locked-in Syndrome - Your diagnosis or condition began at least one year before joining the trial - You have complete or partial paralysis of all four l...

**Who might be able to join this trial:** **Study 1 – Initial Assessment/Screening** - People who have been diagnosed with a disorder of consciousness or a low awareness state — this includes unclear diagnoses in low awareness states, vegetative state, or minimally conscious state - People with locked-in syndrome or c...

**Who might be able to join this trial:** - Adults aged 18 or older, of any race or ethnicity, male or female - People who do not currently have any symptoms of ALS or a related condition called fronto-temporal dementia - People who have already had genetic testing that found a gene linked to ALS - People who have a p...

Who might be able to join this trial: - You have been diagnosed with Amyotrophic Lateral Sclerosis (ALS), a condition affecting the nerves that control movement, confirmed using standard diagnostic guidelines (called the El Escorial criteria), including definite, probable, or possible ALS. - You have a condition called...

Who might be able to join this trial: - People who have been diagnosed with ALS (also known as Lou Gehrig's disease) in one of several forms, including possible, probable, or definite ALS, or forms that mainly affect movement control from the lower or upper nervous system, or that affect swallowing and speech (bulbar)...

**Who might be able to join this trial:** - People who have been diagnosed with ALS (also known as Lou Gehrig's disease) by a study doctor, confirmed through specific diagnostic criteria. - People who are between 21 and 80 years of age (inclusive). - People who are taking the ALS medication riluzole must have been on a...

**Who might be able to join this trial:** - People who have been diagnosed with Motor Neurone Disease (MND), including ALS (possible, probable, or definite), Primary Lateral Sclerosis, or Progressive Muscular Atrophy - People who are over 18 years old - Women who could become pregnant must have a negative pregnancy te...

**Who might be able to join this trial:** - People who are a member of a family where at least one person has a known gene change linked to a condition called familial frontotemporal lobar degeneration (FTLD), specifically in genes called MAPT, GRN, C9orf72, or other rare related genes - People from a family where mul...

Who might be able to join this trial: - You must be age 5 or older - You may qualify under one of several groups: (1) you have a genetic diagnosis of ALS4 (a specific gene mutation called SETX); (2) you have a genetic diagnosis of a related condition affecting how the body processes genetic material (such as RNaseH1, R...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease) and your diagnosis meets recognized medical guidelines called the "revised El Escorial criteria" (confirm with trial site) - You are being seen at one of the participating medical centers involved in this t...

**Who might be able to join this trial:** - People who have been diagnosed with probable or possible Multiple System Atrophy (a condition affecting movement, balance, and automatic body functions) based on recognised medical guidelines - People who have been diagnosed with probable or possible Progressive Supranuclear...

**Who might be able to join this trial:** - People who have been diagnosed with a brain or nervous system condition such as Alzheimer's disease, Parkinson's disease, ALS (Lou Gehrig's disease), or a related condition - People who have a family history of certain inherited brain or nervous system diseases (such as famil...

**Who might be able to join this trial:** - You have agreed to take part in the research and have signed a consent form - You are able to understand what the study is about and what taking part involves - You are covered by French social security or an equivalent scheme - You have been diagnosed with ALS (Amyotrophic L...

**Who might be able to join this trial:** - You have signed a consent form agreeing to take part in the study - You have been assessed by doctors and are suspected to have ALS (also known as Lou Gehrig's disease or motor neurone disease), based on recognised diagnostic guidelines - A doctor has found signs of damage to...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease), either confirmed or probable, based on recognised medical guidelines. - You are over 18 years old. - You are willing and able to sign a consent form agreeing to take part. - If you are taking Riluzole (a c...

Who might be able to join this trial: - Adults aged 18 years or older. - People diagnosed with ALS (also known as Motor Neurone Disease) at any stage of diagnostic certainty, from "possible" to "definite," based on a standard set of medical guidelines called the revised El Escorial criteria. - People with ALS who are c...

Who might be able to join this trial: - Adults aged 18 or older - People who have been diagnosed with ALS (also known as Lou Gehrig's disease or motor neurone disease) - People who are able and willing to sign a consent form and agree to share their relevant health information with the research team Who may not be abl...

**Who might be able to join this trial:** - You must have already taken part in the original NO-ALS study and completed it (patients from either treatment group in that study are welcome to apply) **Who may not be able to join:** - People who have dementia, frontotemporal dementia (a type of brain condition affecting...

**Who might be able to join this trial:** - People experiencing symptoms such as arm or leg weakness, stiff or abnormal walking, muscle wasting, muscle twitching, difficulty swallowing, difficulty speaking, shortness of breath, overactive reflexes, or previous test results showing signs of muscle nerve damage (for one...

Who might be able to join this trial: **People with ALS, ALS-FTD, or a similar neurodegenerative disease:** - People who have received a formal diagnosis of ALS (at any level of certainty, based on established diagnostic guidelines) or a similar neurodegenerative disease. - People who are willing to give their consent...

Who might be able to join this trial: - You have been diagnosed with ALS (also known as Lou Gehrig's disease), either as a probable or confirmed diagnosis - You are able to give your own consent to take part in the trial Who may not be able to join: - You are not able to give your own informed consent to participate i...

**Who might be able to join this trial:** *For people with ALS:* - You are 18 years of age or older - You have been diagnosed with ALS based on recognised medical guidelines called the Gold Coast criteria - Your lung function (how much air your lungs can hold) is at least 30% of what is expected for someone of your ag...

**Who might be able to join this trial:** **If you are a healthy volunteer (no disabilities):** - You are in good general health - You have normal vision, or your vision is corrected with glasses or contact lenses - You have no history of neurological or psychiatric conditions - You are able to read and understand Eng...

Who might be able to join this trial: **For patients:** - You must be 18 years old or older - You must have been diagnosed with ALS (also known as Lou Gehrig's disease) - You must already be receiving regular check-ups every 3 months at the University Medical Centre Ljubljana, Division of Neurophysiology - You must be...

Who might be able to join this trial: - You have been diagnosed with Amyotrophic Lateral Sclerosis (ALS), confirmed or very likely according to specific medical guidelines (the revised Escorial criteria) - You do not currently need a breathing support machine (non-invasive ventilation) - You are an adult (18 years or o...

"Who might be able to join this trial: - People who have been clinically diagnosed with spasticity that is getting progressively worse over time Who may not be able to join: - No exclusion criteria were listed in the available information (confirm with trial site) Important: Always verify eligibility with the trial s...

Who might be able to join this trial: - People who have given their consent to participate in the trial - People who have been diagnosed with one of the following conditions: Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), Glioblastoma (a type of brain tumour), certain cancers without a neurological disease (...

**Who might be able to join this trial:** **General requirements for all participants:** - A person must be able to understand and sign the consent and privacy forms before any study procedures begin - Women who cannot become pregnant must have had a sterilisation procedure (such as removal of the uterus, fallopian tu...

**Who might be able to join this trial:** - Adults aged 18 or older who have been diagnosed with ALS (either inherited or not inherited from a family member). - In Part 1 of the study: people whose ALS is expected to progress at a certain rate, measured by a specific scoring system called the ENCALS risk profile (scor...

**Who might be able to join this trial:** *If you have ALS or are suspected to have ALS:* - You have been diagnosed with ALS (at any level of certainty) or a related nerve disease that may include ALS features, OR you have been referred to a doctor because ALS is suspected - You have a close blood relative (parent, si...

**Who might be able to join this trial:** **For patients:** - You are 18 years of age or older - You have been diagnosed with ALS (Lou Gehrig's disease) and have already attended at least two multidisciplinary appointments at the ALS center in Marseille, including a session with a clinical psychologist - You have a mo...

**Who might be able to join this trial:** *For patients:* - You have been diagnosed with a condition called ALS (also known as Lou Gehrig's disease), based on recognised medical guidelines - Your ALS has progressed to a point where your doctor has recommended a type of breathing support machine used at home (called lo...

Who might be able to join this trial: - You have been diagnosed with ALS (also known as Lou Gehrig's disease) and your physical/movement symptoms started no more than 18 months ago. Who may not be able to join: - You have difficulty processing sugar (such as diabetes or pre-diabetes), or you have another condition tha...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease), confirmed as "probable" or "certain" using a specific medical classification system - Your ALS affects your spine, the muscles used for swallowing/speaking (bulbar), or your breathing (respiratory form) -...

Who might be able to join this trial: - People who have been diagnosed with a long-term (chronic) neurological condition affecting the brain or nervous system Who may not be able to join: - People who are unwilling to have their medical data stored and shared as part of this registry study Important: Always verify el...

**Who might be able to join this trial:** - You have been diagnosed with ALS (Amyotrophic Lateral Sclerosis), either inherited or non-inherited, confirmed using standard medical guidelines - You are between 18 and 80 years old - Your ALS symptoms started no more than 18 months ago - Your ALS function rating score is a...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also called Lou Gehrig's disease) based on the 2020 Gold Coast diagnostic guidelines - You are 18 years of age or older - You are able to understand and agree to the study procedures and treatments on your own - You are allowed to be currentl...

**Who might be able to join this trial:** - You are 18 years old or older - You have been diagnosed with ALS (also known as Lou Gehrig's disease), confirmed using a standard set of medical guidelines called the "revised El Escorial criteria" - You have breathing difficulties caused by weakness in your diaphragm (the ma...

**Who might be able to join this trial:** **If you have ALS (with or without frontotemporal dementia symptoms):** - You are 18 years of age or older - You have been diagnosed with ALS using a standard set of medical criteria - Your muscle weakness or speech problems began no more than 24 months before joining the stud...

**Who might be able to join this trial:** - You have been given a prescription for genetic testing related to ALS (or familial hypercholesterolemia, which is a hereditary cholesterol condition, if joining the control group) - You have agreed and given your written consent to take part in the genetic study and to have y...

**Who might be able to join this trial:** - You have been recently diagnosed with ALS (also known as Lou Gehrig's disease), confirmed by your doctor using standard diagnostic guidelines. - You are being seen and monitored at one of the participating ALS specialist centres — seven located in France and two in Germany. -...

**Who might be able to join this trial:** - You have been diagnosed with ALS (Lou Gehrig's disease) using one of two recognized diagnostic systems used by doctors (confirm with trial site) - You have some, but not complete, weakness in the fingers of at least one hand — meaning you can still move your fingers a little...

**Who might be able to join this trial:** - People between 18 and 70 years old - People who have been diagnosed with locked-in state (a condition where a person is conscious but unable to move or speak), or who are likely to progress into this state within an estimated 2 years, due to a brain injury, brainstem stroke,...

Who might be able to join this trial: - You have been referred for a nerve and muscle test because doctors suspect you may have motor neuron disease, OR you have been diagnosed with ALS (a type of motor neuron disease) within the last 3 months - You are 18 years old or older - You are willing and able to agree to take...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease), either as a confirmed or probable diagnosis, based on recognised medical criteria. - You are over 18 years old. - You are willing and able to sign a consent form agreeing to take part. - If you are taking...

Who might be able to join this trial: - You are aged 18 or older, either male or female - You have been diagnosed with Amyotrophic Lateral Sclerosis (ALS, also known as Motor Neurone Disease) - You are experiencing, or beginning to experience, problems related to speaking, excessive saliva, or difficulty swallowing, as...

**Who might be able to join this trial:** - People who are able to understand the study information and are willing to sign a consent form. - Adults aged 18 to 85 years old at the time of signing the consent form. - People who have a confirmed diagnosis of familial or sporadic ALS, meeting specific diagnostic standard...

Who might be able to join this trial: **For people with ALS (also called PALS):** - People who have been diagnosed with ALS based on a specific set of standard diagnostic guidelines (known as the revised El Escorial criteria) - People who have no history of other neurological conditions, such as stroke - People who sh...

**Who might be able to join this trial:** - People who have been diagnosed with amyotrophic lateral sclerosis (ALS), either as a possible, probable, or confirmed diagnosis, based on recognised medical criteria - People whose first ALS symptoms (muscle weakness or speech/swallowing problems) began less than 24 months a...

Who might be able to join this trial: - You have been diagnosed with ALS (also known as Lou Gehrig's disease) or another type of motor neuron disease Who may not be able to join: - You do not wish to take part in the study Important: Always verify eligibility with the trial site directly before applying.

Who might be able to join this trial: - People who have been diagnosed with ALS (also known as Lou Gehrig's disease) or another type of motor neuron disease - People who live near one of the study centers Who may not be able to join: - People who do not wish to take part in the study - People who are unable or unwilli...

**Who might be able to join this trial:** - You have received a relevant diagnosis that the trial is studying (confirm with trial site for the specific diagnosis) - You are 18 years of age or older - You have had a cognitive (memory and thinking) screening assessment done in person within the last 6 months **Who may n...

Who might be able to join this trial: - The person must be willing and able to give written consent before any study procedures begin, and must understand what they are agreeing to. - The person must have a confirmed or probable ALS diagnosis based on a standard set of diagnostic guidelines called the revised El Escori...

**Who might be able to join this trial:** - People who were diagnosed with relapsing-remitting multiple sclerosis (a type of MS with flare-ups and periods of recovery) more than 5 years ago, based on specific diagnostic guidelines called the McDonald criteria - People who have not had an MS relapse (flare-up) for at l...

Who might be able to join this trial: - People who have been diagnosed with ALS (also known as motor neurone disease) within the last 6 months, based on a specific set of diagnostic guidelines called the Gold Coast Criteria. Who may not be able to join: - People who are unable to answer survey questions on their own o...

**Who might be able to join this trial:** - You have severe paralysis of both arms and legs (called quadriplegia or tetraplegia) caused by either a spinal cord injury or ALS, with very little or no movement in your hands, wrists, and arms, and this has been the case for at least 1 year with no improvement - Doctors exp...

**Who might be able to join this trial:** - You are an adult (any gender) who is willing to give written consent to take part in the study - You are covered by a social security (health insurance) scheme - **If you have ALS:** You have been diagnosed with ALS using established medical criteria, and either have a famil...

**Who might be able to join this trial:** - You have been diagnosed with ALS (either in your family history or with no known family cause), confirmed by standard diagnostic guidelines - You are able to understand and agree to take part in the study, and can follow the study procedures as judged by the research team - Y...

**Who might be able to join this trial:** - People aged 18 or older - People who have been diagnosed with ALS (also called Lou Gehrig's disease), confirmed using established medical guidelines known as the revised El Escorial criteria - People whose lungs are working at 50% capacity or more, based on a breathing test...

**Who might be able to join this trial:** **If you have a neurological condition:** - You are 45 years of age or older - You are a man or a woman - You have been diagnosed with one of the following conditions: Alzheimer's disease, frontotemporal lobe dementia (a type of dementia), Parkinson's disease, atypical Parkins...

Who might be able to join this trial: - People with ALS (a nervous system disease affecting muscle control) who are between 50 and 60 years old and have a similar age when their disease started and a similar length of time since diagnosis as other participants. - People with multiple sclerosis (MS) who have recently be...

Who might be able to join this trial: - You are male or female, of any age, and have been diagnosed with hereditary spastic paraplegia type 4 (SPG4) or hereditary spastic paraplegia type 5A (SPG5A) based on both your symptoms and a genetic test. Who may not be able to join: - You do not have a confirmed diagnosis of S...

**Who might be able to join this trial:** - You are willing to take part and sign a consent form before any study procedures begin. - You are 18 years of age or older at the time you sign the consent form. - You have been diagnosed with ALS (also known as Lou Gehrig's disease) according to recognised international diag...

**Who might be able to join this trial:** **People with ALS:** - People diagnosed with ALS or probable ALS (based on recognised diagnostic guidelines called the El Escorial Criteria), whether they are able to walk or are in hospital - People who are able to give their own informed consent to participate **People with...

**Who might be able to join this trial:** **If you have ALS:** - You are 18 years of age or older - You are able to understand and agree to take part in the study on your own - You are willing to follow the study's procedures - A doctor has diagnosed you with ALS - You have access to a smartphone, tablet, or computer...

**Who might be able to join this trial:** - People aged 18 years or older - People who are able to understand and agree to participate in the study - People who are willing to follow the study's procedures - People who are a close family member (parent, child, or sibling) of someone known to carry a gene linked to ALS...

Who might be able to join this trial: **For healthy volunteers:** - You are a healthy adult (male or female) with no diagnosed medical conditions - You are 18 years of age or older - You have normal thinking and memory abilities - You are able to understand what the study involves - You are willing to complete all par...

**Who might be able to join this trial:** - People who are over 18 years old - Twin pairs (either identical or non-identical twins) where both twins are willing to take part and able to give their consent to join the study - Twin pairs where at least one twin has been diagnosed with ALS (a disease affecting the nerves...

**Who might be able to join this trial:** - People aged between 18 and 80 years old, of any gender - People whose ALS symptoms first began no less than 6 months ago and no more than 2 years ago - People who have received a formal ALS diagnosis that meets a specific international diagnostic standard (the El Escorial rev...

**Who might be able to join this trial:** - People who have been newly diagnosed with definite or probable ALS (also known as motor neurone disease), based on recognised medical diagnostic guidelines, and are being followed at one of the participating specialist centres - People who are 18 years of age or older - Peopl...

**Who might be able to join this trial:** - People who have been diagnosed by their neurologist with possible, probable, or definite ALS (also called motor neuron disease), based on a specific set of medical criteria. - People who are already planning to have a feeding tube placed within the next 4 to 6 weeks. **Who m...

**Who might be able to join this trial:** - People aged 18 to 80 years old - People who have been diagnosed with ALS (either sporadic or familial), at any level of diagnostic certainty under the revised El Escorial criteria - People whose ALS symptoms first appeared 3 years ago or less - People whose lung breathing ca...

**Who might be able to join this trial:** - Adults aged 18 or older. - People who have been diagnosed with ALS (also called Lou Gehrig's disease) that meets a specific set of recognised diagnostic standards called the "El Escorial criteria" — covering possible, probable, or definite ALS diagnoses. - People whose lungs...

**Who might be able to join this trial:** - People who are able to understand the purpose and risks of the study and are willing to give their formal consent to participate, in line with local laws. - People who are 18 years of age or older. - People who have been diagnosed with ALS (also known as motor neurone diseas...

Who might be able to join this trial: - You have been diagnosed with definite multiple sclerosis (MS), or a confirmed MS diagnosis supported by lab results - You have been diagnosed with definite, probable, or lab-supported amyotrophic lateral sclerosis (ALS), a disease affecting the nerves that control movement - You...

**Who might be able to join this trial:** - You are between 18 and 70 years old - You have been diagnosed with ALS (either familial or sporadic) according to recognised international diagnostic standards, confirmed as probable or definite - If you are already taking riluzole (Rilutek®) and/or edaravone (Radicava®), yo...

Who might be able to join this trial: - People who have been diagnosed with sporadic ALS (the non-inherited form) that has been confirmed as "definite" or "clinically probable" according to recognised international diagnostic guidelines - People whose lung breathing capacity is at least 50% of the expected level for th...

**Who might be able to join this trial:** - People who have severe paralysis of both arms and legs (and limited or no movement in the hands, wrists, and arms) caused by a spinal cord injury or ALS (Lou Gehrig's disease), lasting at least 1 year with no improvement - People with a life expectancy of at least 12 months...

**Who might be able to join this trial:** - People of any sex who have been diagnosed with ALS (Lou Gehrig's disease) using a standard set of medical guidelines called the revised El Escorial criteria - People between 18 and 80 years old - People whose lungs are working at more than 50% of the expected capacity for som...

**Who might be able to join this trial:** - People who have been diagnosed with amyotrophic lateral sclerosis (ALS) according to the Gold Coast Criteria (2020) - People aged 18 or older, of any gender - People whose ALS breathing-related symptoms score at least 1 point on a standard ALS rating scale (ALSFRS-R) across...

**Who might be able to join this trial (for people with ALS):** - Your symptoms started less than 36 months (3 years) ago - You have been diagnosed with ALS confirmed by one of two standard sets of medical guidelines (El Escorial or Awaji-Shima criteria) — your doctor can confirm which applies to you - A breathing test...

**Who might be able to join this trial:** - You are willing to take part, have been fully informed about the study, and agree to sign a consent form and follow all study procedures. - You are between 18 and 80 years old (any gender), and if you are 18 or older with ALS, you weigh more than 40 kilograms (about 88 pounds...

**Who might be able to join this trial:** - You (or your legal guardian) must be willing to give written consent to take part in this study. - You must be between 18 and 60 years old; any gender may apply. - You must have been officially diagnosed with ALS (Lou Gehrig's disease) using internationally recognised guidel...

**Who might be able to join this trial:** - People diagnosed with Parkinson's disease who show at least 2 of the 4 main symptoms (tremor, muscle stiffness, slowness of movement, or symptoms starting on one side of the body), where one of those symptoms must be tremor or slowness of movement - People with Parkinson's d...

Who might be able to join this trial: - A family member, caregiver, or other trusted person (called a Legally Authorised Representative) must be available to give consent on the participant's behalf and be present throughout the study - There must be a specific person available who can be trained to use the Cognixion c...

**Who might be able to join this trial:** **For people with ALS (also called PALS):** - You have been officially diagnosed with ALS (amyotrophic lateral sclerosis) based on standard diagnostic guidelines - You have no history of other neurological conditions, such as a stroke - You do not have cognitive impairment (th...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease) by a neurologist, at any confirmed level of certainty using standard diagnostic guidelines. - You are already enrolled in a related research study called "Precision ALS." - You are able to understand what t...

Who might be able to join this trial: - You passed a hearing screening test done remotely (online or by phone) - You do not have any known speech, language, or neurological conditions, based on what you report about yourself - You are a native speaker of American English and speak only English as your first language -...

**Who might be able to join this trial:** - People aged 18 to 80 years, of any gender - People who have been diagnosed with a spinal cord injury, a brainstem stroke, amyotrophic lateral sclerosis (ALS), another motor neuron disease that causes partial or complete paralysis, or who have had both arms amputated - People...

Who might be able to join this trial: - People aged 18 or older - People who have been diagnosed with ALS (also known as motor neurone disease) based on recognised international diagnostic guidelines - People whose symptoms started less than 24 months ago - People whose ALS functional rating score is above 30 at the ti...

**Who might be able to join this trial:** - You are an adult who has been diagnosed with Motor Neurone Disease (MND) by a specialist neurologist. - Your breathing tests show that you have too much carbon dioxide building up in your blood during the day, or you have symptoms of breathing difficulties (such as breathless...

**Who might be able to join this trial:** - You are willing to participate and have signed a consent form showing you understand the study's purpose and risks - You are 18 years old or older (any gender) - You have been diagnosed with ALS (Lou Gehrig's disease) using standard international diagnostic guidelines, and g...

**Who might be able to join this trial:** - People who have been diagnosed with ALS (Amyotrophic Lateral Sclerosis, also known as Motor Neurone Disease) based on recognised medical diagnostic standards - People who have been diagnosed with FTD (Frontotemporal Dementia) based on recognised medical diagnostic standards...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease), either as a possible, probable, or confirmed case, based on recognised international diagnostic guidelines - Your ALS symptoms have been progressing at a certain rate since they first began — this is calcu...

Who might be able to join this trial: - People who are 18 years of age or older - People who can read and write in English - People who have been diagnosed with ALS/MND (also known as Motor Neurone Disease or Amyotrophic Lateral Sclerosis), or who have been found to carry a gene mutation linked to ALS Who may not be a...

Who might be able to join this trial: **All participants must meet these criteria:** - People who are able to give written consent before any study assessments begin. - Women who are not able to become pregnant, or who agree to use reliable contraception and not donate eggs for 30 days after the PET scan (pregnancy te...

**Who might be able to join this trial:** - People who have been diagnosed with ALS (also known as Amyotrophic Lateral Sclerosis, or Motor Neurone Disease) **Who may not be able to join:** - People with ALS who are under 18 years of age **Important: Always verify eligibility with the trial site directly before applyi...

**Who might be able to join this trial:** - People aged 18 to 65 years, of any gender - People whose spinal cord was injured due to a traumatic event or a complication of surgery, affecting the spine between the neck (C4 level) and lower back (L2 level) - People whose spinal cord injury has been classified as ASIA Imp...

**Who might be able to join this trial:** - You have been diagnosed with a spinal cord injury, stroke, or other neurological condition (for at least 12 months) that has caused permanent movement problems in both arms and hands, with no expectation of recovery. - **OR** you have been diagnosed with ALS (Lou Gehrig's di...

**Who might be able to join this trial:** - You have been experiencing an adjustment disorder (a stress-related condition affecting mood) for at least 4 weeks, with symptoms of low mood or a mix of anxiety and low mood, confirmed by a doctor's interview - Your adjustment disorder was triggered by one of the following m...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease), either confirmed by lab tests or based on current clinical diagnostic standards - You are over 18 years old - Your ALS symptoms first appeared no more than 24 months (2 years) ago - Your condition has been...

**Who might be able to join this trial:** - People who have been diagnosed with ALS (also known as motor neurone disease) using a specific set of diagnostic standards called the Gold Coast Criteria - People who are 18 years of age or older at the time of joining - People whose ALS is progressing quickly, based on score...

Who might be able to join this trial: - People between 18 and 80 years of age - People who have been diagnosed with any type of motor neuron disease (MND) - People whose MND is considered mild to moderate in severity, as measured by a clinical tool called the Sinaki-Mulder scale (specifically, a score between 1 and 3 o...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease) using a specific set of diagnostic guidelines called the "Gold Coast Criteria," and this diagnosis was made within the last 6 months - You are 18 years of age or older - You are willing and able to take par...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease), either as a probable or confirmed diagnosis, based on recognised medical guidelines (called the El Escorial criteria). - You are an adult. - You are covered by a social security or health insurance scheme....

Who might be able to join this trial: - You have been diagnosed with ALS (also known as Lou Gehrig's disease) — as definite, possible, or probable — by a doctor who specializes in managing this condition. - Your ALS symptoms started no more than 24 months (2 years) before your screening appointment, as determined by th...

**Who might be able to join this trial:** - You are between 18 and 75 years old (including those ages exactly) - You have been diagnosed with ALS (either "definite" or "probable") based on a specific set of recognised diagnostic guidelines - Your lung breathing capacity (measured by a breathing test called FVC) is at l...

**Who might be able to join this trial:** - You have been diagnosed with a spinal cord injury, brain stem stroke, or another neurological condition that means you cannot walk and have significant weakness or loss of movement in both arms and hands, making it very difficult or impossible to use a computer, smartphone,...

Who might be able to join this trial: - People who have been diagnosed with Motor Neurone Disease (MND) - People who are currently living in the United Kingdom Who may not be able to join: - No specific exclusion criteria were listed in the official trial information (confirm with trial site) Important: Always verify...

Who might be able to join this trial: - People who have been diagnosed with ALS (also known as Lou Gehrig's disease), confirmed using established medical criteria that look at nerve and muscle function, how symptoms have spread, and ruling out other conditions. - People aged 18 to 75 years old (male or female). - Peopl...

Who might be able to join this trial: - People who have been diagnosed with ALS (also known as Motor Neurone Disease) based on recognised medical diagnostic standards called the El Escorial or Gold Coast criteria - People who are 18 years of age or older - People who are able to understand the trial information and are...

**Who might be able to join this trial:** - You are 18 years old or older - You have a history of a spinal cord injury at the neck level (at or above the C6 vertebra) - Your spinal cord injury occurred more than 1 year ago and your condition has been neurologically stable since then - A doctor has cleared you to take p...

**Who might be able to join this trial:** - You have been diagnosed with ALS (possible, probable, or definite) or with definite Primary Lateral Sclerosis (PLS), as confirmed by your neurologist - You experience jaw pain that you would rate at least a 3 out of 10 on a pain scale **Who may not be able to join:** - You h...

**Who might be able to join this trial:** **Group 1 – People who carry a gene mutation linked to ALS but have no symptoms:** - Adults aged 18 to 90 - People who have given written agreement to take part - People who are covered by a social security/health insurance scheme (confirm with trial site) - People who have be...

**Who might be able to join this trial:** - Adults aged 18 to 55 years (inclusive) who are considered generally healthy, either male or female. - Female participants must be of non-childbearing potential, meaning they have had a sterilisation procedure (such as tubal ligation, removal of both fallopian tubes, hysterec...

Who might be able to join this trial: - People who are 18 years of age or older at the time of signing the consent form - People who have been diagnosed with SOD1-ALS (a specific genetic form of ALS caused by a mutation in the SOD1 gene) - People taking riluzole (an ALS medication) who have been on a stable dose for at...

**Who might be able to join this trial:** - You are an adult who has been diagnosed with ALS, PLS, stroke, or a spinal cord injury - You have severe difficulty speaking - You have significant difficulty using your arms and/or hands - Doctors expect you to live for at least 12 more months - You are able to communicate i...

**Who might be able to join this trial:** - People who have been diagnosed with idiopathic Parkinson's disease (a common form of Parkinson's not caused by another condition). - People whose Parkinson's medication has remained the same for the past month and is expected to stay the same for the next 3 months. - People...

Who might be able to join this trial: - You have been diagnosed with ALS (Amyotrophic Lateral Sclerosis), MND (Motor Neurone Disease), or PLS (Primary Lateral Sclerosis) Who may not be able to join: - You are a smoker Important: Always verify eligibility with the trial site directly before applying.

Who might be able to join this trial: - You have been diagnosed with a condition where the nerves in the brain or body gradually break down over time (such as diseases that cause progressive loss of nerve function) (confirm with trial site) Who may not be able to join: - You have not been diagnosed with a condition wh...

**Who might be able to join this trial:** - You are 20 years old or older - You have been diagnosed with ALS (also known as Lou Gehrig's disease) based on specific recognised medical criteria - You are not currently using a breathing support machine (such as a CPAP or BiPAP mask) and have not had a breathing tube surgi...

Who might be able to join this trial: - You have been diagnosed with ALS (also known as Lou Gehrig's disease) and have a confirmed genetic change in the SOD1 gene, and your information comes from a contributing patient registry network. Who may not be able to join: - Your data may not be included if it was collected w...

**Who might be able to join this trial:** *People with ALS (Lou Gehrig's disease):* - You are 18 years of age or older - You have been formally diagnosed with ALS using standard diagnostic guidelines - Your symptoms started less than 24 months (2 years) ago *People who carry a gene linked to ALS but have no symptoms...

Who might be able to join this trial: - People who are willing and able to give written consent and follow all study requirements, including attending study site visits - People aged 18 or older, of any gender - People who have been diagnosed with ALS (also called Motor Neurone Disease) according to a specific set of m...

**Who might be able to join this trial:** - Your Body Mass Index (BMI) — a measure of body weight relative to height — must be 18 or above. - You must have been diagnosed with ALS (also known as Lou Gehrig's disease) with symptoms, confirmed using a specific set of diagnostic guidelines called the Gold Coast criteria....

Who might be able to join this trial: - People diagnosed with ALS (also known as motor neurone disease) who are between 18 and 70 years old - People whose ALS diagnosis has been confirmed using a specific set of medical standards called the Gold Coast criteria - People who are able to sit up on their own without suppor...

**Who might be able to join this trial:** - You are 18 years old or older at the time of signing the consent form. - You have been officially diagnosed with ALS (Lou Gehrig's disease). - Your ALS muscle weakness began no more than 24 months (2 years) before your screening visit. - You have had genetic testing confirmi...

Who might be able to join this trial: - You have been diagnosed with ALS (also known as Lou Gehrig's disease), whether possible, probable, or confirmed - You have not previously done any tongue strengthening exercises - Your tongue strength is weaker than what is considered normal for your age group - You scored less t...

Who might be able to join this trial: **For people living with ALS:** - A person must have been diagnosed with ALS that is linked to a specific genetic change called C9orf72 - A person must be 18 years of age or older - A person must be fluent in the Italian language - A person must be able to understand what the stud...

Who might be able to join this trial: **For people with ALS:** - You have been diagnosed with Amyotrophic Lateral Sclerosis (ALS) - You are 18 years old or older - You are able to have a lumbar puncture (a procedure where a small sample of fluid is taken from your lower back) - You are willing and able to give your co...

Who might be able to join this trial: - People who have been diagnosed by a neurologist with a first-time injury to the part of the nervous system that controls movement (the pyramidal tract), resulting in stiffness or tightness in one arm - People who do not have any problems with thinking, memory, or understanding -...

**Who might be able to join this trial:** - You have been diagnosed with definite or probable ALS (also known as Lou Gehrig's disease), confirmed using a standard set of diagnostic guidelines called the El Escorial criteria. - Your ALS symptoms started no more than 18 months before your screening appointment. - Your lu...

**Who might be able to join this trial:** *For people being evaluated for ALS:* - You are 18 years old or older - Your doctor suspects you may have ALS (amyotrophic lateral sclerosis) but it has not necessarily been confirmed yet - You are already scheduled to stay at the HFAR neurology department for a standard set o...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease), based on recognised medical diagnostic guidelines - You are 18 years of age or older and are able to understand the study information and sign a consent form - You are willing and able to do a personalised...

**Who might be able to join this trial:** - People who have been clinically diagnosed with a progressive neuromuscular disease or a neurological injury. - People who have been clinically diagnosed with anarthria (complete loss of the ability to speak) or severe dysarthria (very significant difficulty speaking). - Peopl...

**Who might be able to join this trial:** *For the main study group (people with cerebral palsy):* - You have a confirmed diagnosis of cerebral palsy, supported by medical history and test results - You are between 7 and 25 years old at the time of joining the study - You score at least 70 on at least one measure of v...

**Who might be able to join this trial:** **Healthy volunteers:** - People who give written agreement to take part before any screening begins, either personally or through a legally authorised representative. - People who use a highly effective form of contraception, such as implants, injections, combined oral contra...

Who might be able to join this trial: - People aged between 21 and 75 years old. - People (in the "control" group) who are scheduled for planned neck spine surgery that includes a specific procedure to relieve pressure on the spinal cord (called a decompressive laminectomy), where nerve monitoring is already being done...

**Who might be able to join this trial:** This trial is open to three different groups of people: **If you have a Spinal Cord Injury (SCI):** - You are 18 years of age or older - You have been diagnosed with a spinal cord injury at a certain level of the upper spine (at or above the first thoracic vertebra, meaning a...

Who might be able to join this trial: - You have been diagnosed with ALS (Lou Gehrig's disease) that affects the spinal area (rather than starting in the throat or mouth) - You can be male or female - Your ALS diagnosis was made less than two years ago, confirmed using a specific set of medical standards called the "El...

**Who might be able to join this trial:** - You have been diagnosed with ALS (Lou Gehrig's disease) using a specific set of recognised diagnostic guidelines called the Gold Coast criteria - Your ALS symptoms started no more than 18 months ago - You are between 18 and 75 years old - Your ALS functioning score (a standa...

**Who might be able to join this trial:** - People who are able to give their informed consent to take part, as judged by the study doctors - People who have been diagnosed with amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND), with weakness in both arms - People aged 18 years or older - People whose...

Who might be able to join this trial: - People who are 18 years of age or older - People who have been diagnosed with Amyotrophic Lateral Sclerosis (ALS) or Motor Neuron Disease (MND) - People who are able to understand the study information and are willing to sign a consent form and follow the study procedures - Peopl...

Who might be able to join this trial: - You have been diagnosed with ALS (also known as Lou Gehrig's disease) and have weakness in your neck muscles Who may not be able to join: - You have difficulties with thinking, memory, or vision that could make it unsafe to use the study device or complete the required tasks Im...

Who might be able to join this trial: - Adults aged 18 or older who have been diagnosed with ALS (also known as Motor Neurone Disease) by a neurologist Who may not be able to join: - People who have a known lung or breathing condition - People who have unstable heart disease, uncontrolled high blood pressure, or reduc...

**Who might be able to join this trial:** - You are able to give your agreement (consent) to take part in the study. - You have been diagnosed with ALS (also known as Lou Gehrig's disease) and have weakness in both arms. - Your ALS has not responded to treatment and you have had it for at least six months. - You are 2...

**Who might be able to join this trial:** - You must have already completed both the main treatment phase and any off-treatment phase of the parent study (called Study OWAA), including any required screening steps from a linked screening protocol. **Who may not be able to join:** - You have a history of significant ba...

Who might be able to join this trial: - You must have fully completed a related ("parent") study that was testing a treatment for ALS, including both the treatment period and any follow-up period after treatment ended (note: missing individual visits during that study does not disqualify you) Who may not be able to jo...

Who might be able to join this trial: - Be between 7 and 16 years old - Have been diagnosed with cerebral palsy that affects one side of the body, confirmed by a children's brain specialist - Be able to walk and move at a fairly independent level (levels I or II on a standard movement ability scale used by doctors) - S...

**Who might be able to join this trial:** - You have been diagnosed with ALS (also known as Lou Gehrig's disease) using a specific set of medical guidelines called the Gold Coast criteria. - Your ALS symptoms started less than 36 months (3 years) before the study screening visit. - Your lungs are working at 50% or more...

Who might be able to join this trial: - People diagnosed with ALS (also known as Lou Gehrig's disease) who are older than 20 years and have a specific protein in their blood called anti-NRIP autoantibody - People who are willing to undergo a blood-cleaning treatment called plasmapheresis, which involves filtering the b...