Phase 3 Motor Neurone Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with ALS (Lou Gehrig's disease) using a specific set of diagnostic standards called the "Gold Coast Criteria"
• Your ALS symptoms (such as limb weakness or swallowing/speech difficulties) started less than 24 months ago at the time of joining the trial
• You are still able to manage everyday tasks such as swallowing, handling utensils, and walking at an acceptable level (confirm with trial site)
• Your lungs are working well enough, with breathing capacity at 80% or above of what is considered normal for you
• Your ALS has been measurably getting worse over time, at a rate that meets a specific threshold based on a standard ALS scoring tool (confirm with trial site)
• You are able to understand what the trial involves and follow its requirements
• You are able to sign a consent form yourself, or have a legal representative do so on your behalf
• You have been taking riluzole (a standard ALS medication) at 50mg twice a day for at least 4 weeks before joining
• Your thinking and memory are considered intact by the lead doctor running the trial

Who may not be able to join:

• You have had polio in the past, or currently have an active infection
• You have a different type of motor neuron disease other than ALS
• You have another condition affecting your body in a way that could interfere with how the trial measures its results (confirm with trial site)
• You have a serious health condition, such as a heart problem or cancer, that could affect your survival or physical ability within the next 12 months
• You have previously used a substance called ALCAR (acetyl-L-carnitine) for any reason
• You have a history of not following through with previous medical treatments
• You have taken part in another experimental treatment within the last 3 months before your screening visit (a 3-month waiting period would be required)
• You are a woman who is breastfeeding, or who could become pregnant and is not using adequate contraception — or a man who is unwilling or unable to use contraception during the treatment and for 3 months afterward
• You are unable or unwilling to understand and follow the study requirements
• You are unwilling or unable to take riluzole

⚠️ Important: Always verify eligibility with the trial site directly before applying.