Peripheral Neuropathy Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People must attend an in-person visit at a participating trial centre for the first appointment.
• People with Charcot-Marie-Tooth disease (CMT, any subtype) who have had genetic testing showing a confirmed or likely disease-causing gene change related to CMT.
• People with CMT whose parent, child, sibling, half-sibling, aunt, uncle, grandparent, or grandchild has a confirmed or likely disease-causing CMT gene change, and where there is a clear family connection between that relative and the person with CMT symptoms.
• People with a gene change that was initially reported as "uncertain" by the testing laboratory may still be considered eligible if: the change meets recognised scientific guidelines for being likely disease-causing; or the same change has been found in multiple affected family members but not in unaffected ones (both affected and unaffected members must be tested); or the lead researchers at the trial site agree the change is most likely disease-causing.
• People whose symptoms suggest CMT but where the exact type and gene change are not yet known, categorised by nerve test results and inheritance pattern (confirm with trial site).
• People (or their legal representative) who have read and signed the ethics-approved consent form. Teenagers aged 13–17 and cognitively impaired adults who can read and write are also required to sign an assent form, depending on local ethics requirements.
• People joining as healthy comparison participants (controls) who do not have a peripheral nerve disease, as determined by the investigating doctor, and who have signed the ethics-approved consent form.

Who may not be able to join:

• People who have a gene change reported as "uncertain" that cannot be further classified using the methods described in the inclusion criteria.
• People who do not wish to participate or have not signed the required consent form.
• People considered unsuitable by the lead doctor at the trial site, for reasons determined by that doctor.

Important: Always verify eligibility with the trial site directly before applying.