Phase 3 Long COVID Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are 18 years old or older
- You are any gender (male or female)
- You are willing and able to use an acceptable form of contraception (such as condoms, a diaphragm, or a contraceptive sponge with spermicide) during the study and for at least 3 months after treatment ends (applies to women who could become pregnant and to men)
- You are able to give written consent to take part; if you cannot make that decision yourself, a legally appointed representative may give consent on your behalf
- You had a confirmed COVID-19 infection at least 90 days ago or longer
- You have had symptoms consistent with Long COVID (also called Post-Acute COVID-19 Syndrome) for more than 2 months, meaning these symptoms limit your daily activities
- You have a specific protein in your blood (called IP-10) measured at a level above 250 pg/ml (this would be checked by a blood test)
- You meet at least one of two specific health conditions: Condition 1 — your lung function tests show reduced capacity in certain areas; OR Condition 2 — a chest scan shows significant lung changes, or you can walk less than 500 metres in a 6-minute walking test (confirm details with trial site)
Who may not be able to join:
- You are under 18 years old
- You do not wish to give written consent to participate
- You have a stage IV cancer (the most advanced stage of any cancer)
- You have a condition where your immune system does not work properly from birth or due to a primary medical condition
- Your neutrophil count (a type of white blood cell) is below 1,500 per mm³ (confirm with trial site)
- You have a known allergy or sensitivity to a medicine called anakinra
- You had lung scarring (fibrosis) before you got COVID-19
- You have a history of high blood pressure in the lungs (pulmonary hypertension) or chronic heart failure
- You had a severe form of chronic obstructive pulmonary disease (COPD, stages 3 or 4) before getting COVID-19
- You currently have active or latent (inactive but present) tuberculosis
- You have been taking steroid tablets or IV steroids at a relatively high daily dose for more than the past 15 days (confirm exact dose threshold with trial site)
- You have received any biological treatment that targets the immune system's signalling proteins in the past month
- You have severe liver failure (confirm with trial site)
- You have end-stage kidney failure requiring dialysis or filtration treatment
- You are pregnant or breastfeeding (a urine pregnancy test will be carried out before joining)
- You are currently taking part in any other clinical trial involving a treatment or intervention
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Evangelos Giamarelos-Bourboulis, MD,PhD, Hellenic Institute for the Study of Sepsis
Phone: 00302105831994
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Score of PACS progression reversal
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.