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Back to Chronic Kidney Disease
Phase 2 Chronic Kidney Disease Trial, Recruiting
NCT05928936
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have moderate-to-moderately-severe chronic kidney disease (CKD Stages 3 or 4), people who have received a kidney transplant with any level of kidney function, or people without kidney disease who are participating as comparison subjects
- People who are not currently active — meaning they exercise less than 20 minutes, twice per week
- CKD patients whose kidney function has been stable (not declining significantly) over the past 6 months, and whose blood acid-base levels fall within a specific normal range
- People who also have high blood pressure (hypertension)
Who may not be able to join:
- People with very severe kidney disease (kidney function below a certain threshold)
- People with a blood chemistry imbalance where the blood is too alkaline (confirm with trial site)
- People currently taking bicarbonate supplements or medication
- People with ongoing drug or alcohol misuse
- People with nerve damage related to diabetes, or problems with the body's automatic nervous system
- People with a serious illness that could affect life expectancy
- People with anaemia where their haemoglobin (a measure of red blood cells) is below a certain level
- People with clinical signs of heart failure
- People with excess fluid in the body or reduced heart pumping strength below a certain level
- People with heart disease symptoms identified through heart tests or medical history
- People being treated with a blood pressure medication called clonidine (a central alpha-agonist)
- People who have had a heart attack or stroke within the past six months
- People with poorly controlled high blood pressure above a certain level
- People with blood pressure that is too low
- People who have had surgery within the past 3 months
- People who are pregnant or planning to become pregnant
- People who are unable to ride a stationary exercise bicycle
- People for whom it would not be safe to temporarily stop certain blood pressure medications (alpha- and beta-blockers)
- People with disease affecting the arteries in the legs or arms (peripheral arterial disease)
- People with a BMI over 40 (classified as class 3 obesity)
- People with potassium levels in the blood that are too low or too high
- People currently taking immune-suppressing medications, such as steroids, certain transplant medications, or similar drugs — note: kidney transplant recipients who are on immunosuppression would not be eligible (confirm with trial site)
- People who have a dialysis access point in their body, such as an AV fistula or graft
- People who cannot safely have an MRI scan, including those with a pacemaker, cochlear implants, nerve stimulators, implanted metal devices, other metal in the body, or a history of claustrophobia
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.
Contact this trial
Principal Investigator: Jeanie Park, MD, Emory University
Phone: 404-727-7762
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Status
Recruiting
Phase
Phase 2
Sponsor
Registry
ClinicalTrials.gov
Start date
11 November 2022
Est. completion
1 June 2028
Where this trial is recruiting
🇺🇸 United States
Primary endpoints
Change in Exercise Capacity
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.
Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.