Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been newly diagnosed with a specific type of brain tumour called glioblastoma (GBM, WHO grade IV, IDH wild type) and have had surgery to remove or reduce the tumour
• People who have had a specific gene marker on the tumour (called MGMT methylation status) tested after surgery, regardless of the result
• Adults aged 18 years or older, of any sex
• People who are receiving the standard treatment plan for this type of brain tumour (known as the Stupp protocol), including older patients over 70 who are on a shorter radiation schedule and three weeks of chemotherapy
• People whose general physical functioning, as measured by a specific scoring system (Karnofsky Performance Status), is above 60 after surgery — meaning they are able to care for themselves and carry out some normal activities (confirm with trial site)
• People whose tumour size and location suggest a life expectancy of at least 6 months
• People who are able to communicate with the research team and are willing and able to follow all study procedures, and who have given written consent before any study activities begin
• Women who could become pregnant must have a negative pregnancy test at the start of the trial, and must agree to use a highly effective form of contraception throughout treatment and for four weeks after the last dose — the trial site can advise on which methods are accepted
• Men with female partners who could become pregnant must use condoms during treatment and until the end of relevant exposure from the study treatment

Who may not be able to join:

• People whose glioblastoma has spread to or appears in multiple separate areas of the brain (multicentric GBM)
• People who have been diagnosed with diabetes or any diabetes-related condition
• People who currently have another active cancer
• People who have a known allergy or intolerance to metformin or any of its ingredients
• People with reduced kidney function (creatinine clearance below 60 mL/min), liver failure, or other medical reasons that would prevent safe use of metformin, as assessed at the time of recruitment
• People who are already taking metformin, insulin, or other medications in the same drug family (biguanides), for any reason
• People who are pregnant or currently breastfeeding
• People who have serious pre-existing health conditions that the trial doctor believes would make participation unsafe or unsuitable

Important: Always verify eligibility with the trial site directly before applying.