Phase 3 Melanoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older
• People who received a kidney, liver, heart, or lung transplant at least two years ago
• People who have previously been diagnosed with a type of skin cancer called keratinocyte carcinoma, or a very early form of squamous cell skin cancer, confirmed by a tissue sample (biopsy)
• People who are currently taking anti-rejection medication from a group called calcineurin inhibitors, specifically cyclosporine or tacrolimus
• People who are able to attend follow-up appointments as required by the trial

Who may not be able to join:

• People who have taken nicotinamide or niacin supplements at a dose of 250 mg or more per day in the past 12 weeks
• People who currently have an untreated skin cancer at the time of joining (enrolment may be possible after the skin cancer has been treated)
• People who have had a transplant rejection episode confirmed by biopsy in the past 12 weeks
• People with active liver disease, based on certain blood test results showing significantly elevated liver markers (confirm with trial site)
• People with severely reduced kidney function, based on a specific kidney measurement falling below a certain threshold (confirm with trial site)
• People who have had a serious internal cancer, invasive melanoma, Merkel cell carcinoma, or skin cancer that has spread to other parts of the body within the past five years
• People who are pregnant or breastfeeding
• People who need to take the medications carbamazepine or primidone on an ongoing basis
• People who have a known allergy to nicotinamide or any ingredient in the trial capsules

Important: Always verify eligibility with the trial site directly before applying.