Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older, of any gender
• People with Cushing's syndrome confirmed to be coming from the pituitary gland, shown by consistently high cortisol levels in urine tests, plus normal or raised ACTH hormone levels in the blood, AND either a pituitary tumour larger than 4mm visible on MRI or a specific blood sampling test showing a particular hormone pattern
• People whose Cushing's disease has returned or continued after previous pituitary surgery, confirmed by lab tests and surgical pathology records
• People currently taking medication for Cushing's disease, provided they stop those medications for a set period before the trial begins (the required stop period varies by medication, ranging from 2 to 4 weeks, or longer for some other drugs — confirm exact requirements with the trial site)

Who may not be able to join:

• People with vision problems or any changes in their visual field in the past 6 months
• People whose pituitary tumour is pressing on or touching the optic nerve pathway (the structure connecting the eyes to the brain), even if vision currently appears normal
• People whose Cushing's syndrome is caused by something other than a pituitary tumour that produces ACTH hormone
• People who have had major surgery, including pituitary surgery, within one month before screening, or who have major surgery planned during the trial period
• People with low potassium levels in the blood, unless this is being stably managed with potassium supplements
• People with poorly controlled diabetes, indicated by a blood sugar marker (HbA1c) above 8
• People with poorly controlled high blood pressure (blood pressure at or above 160/100 mmHg)
• People with significant heart problems, including a slow heart rate, a fast abnormal heart rhythm, a heart attack within the past year, or any other heart condition the trial doctor considers a significant health risk
• People with liver disease or a history of liver disease (such as cirrhosis or chronic hepatitis B or C), or people with certain abnormal liver-related blood test results at screening
• People with kidney disease or a history of kidney disease, where kidney function falls below a certain level or where a specific kidney marker in the blood is above a set threshold at screening
• People whose thyroid hormone levels are not within the normal range; people on thyroid replacement medication must have been on a stable dose for at least 3 months
• People known to be HIV-positive or who have any other condition that significantly weakens the immune system
• People with a history of alcohol abuse or use of illegal substances within the past year
• Women who are pregnant, breastfeeding, or capable of becoming pregnant unless willing to use an accepted method of contraception (a double barrier method such as the oral contraceptive pill or diaphragm combined with a partner using a condom, or abstinence if consistently practised); male participants must use a condom with spermicide and agree not to donate sperm for up to 3 months after the main study period ends
• People who have taken part in another clinical trial involving an experimental drug within 1 month before screening, or within 5 half-lives of that experimental treatment, whichever is the longer period
• People currently taking certain medications known to strongly interact with a liver enzyme called CYP3A4 (confirm specific medications with the trial site)
• People who have had radiation treatment to the pituitary gland within the 5 years before the start of the trial
• People who have tested positive for hepatitis B surface antigen
• People who have tested positive for hepatitis C antibodies

Important: Always verify eligibility with the trial site directly before applying.