Phase 1 Non-Alcoholic Fatty Liver Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Women between the ages of 18 and 42 who have been diagnosed with a hormone condition called PCOS that involves higher-than-normal levels of male hormones (androgens)
• Women who have a specific type of liver disease called NASH (a form of fatty liver disease with inflammation), confirmed either by a liver biopsy or by a specialist scan and/or elevated liver enzyme levels in the blood

Who may not be able to join:

• People whose diabetes is not well controlled
• People who have drunk more than 2 alcoholic drinks per day for at least 3 months in a row at any point in the last 5 years
• People who have another ongoing liver condition (such as hepatitis B, hepatitis C, or autoimmune hepatitis) or severe liver scarring (cirrhosis) from any cause
• People who have had, or are planning to have, weight-loss surgery within five years of being diagnosed with NASH confirmed by liver biopsy
• People who are living with HIV
• People who have taken certain medications known to cause fatty liver (such as amiodarone, methotrexate, steroids, tamoxifen, anabolic steroids, or valproic acid) for more than 4 weeks before or during the study
• People who are recently pregnant, currently pregnant, planning to become pregnant, or going through perimenopause
• People with reduced kidney function or high potassium levels in the blood (confirm with trial site)
• People who have taken certain hormone-blocking medications (such as spironolactone or flutamide) for more than 3 months within the year before joining the study

Important: Always verify eligibility with the trial site directly before applying.