Early Phase 1 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with head and neck squamous cell carcinoma (a type of cancer in the head or neck area) confirmed by a tissue or cell sample, or who have a clinical diagnosis of brain metastases (cancer that has spread to the brain).
• People who have at least one tumour that can be measured using a scan or physical examination, meeting minimum size requirements.
• People who are reasonably active and able to carry out daily activities, as measured by standard health scoring tools (confirm with trial site for exact thresholds).
• People who are expected to live longer than 6 months.
• People who are willing and able to use reliable contraception (such as hormonal methods, barrier methods, or abstinence) before and shortly after receiving the study imaging agent, if there is any possibility of pregnancy or of fathering a child.
• People who are able to understand the study and are willing to sign a written consent form.

Who may not be able to join:

• People who have had allergic reactions to substances chemically similar to the study imaging agent (18F-FMISO).
• People with serious uncontrolled health conditions, such as an active infection, heart failure, unstable chest pain, irregular heartbeat, or mental health or social circumstances that would make it difficult to follow the study requirements.
• People whose brain metastases are larger than 3.0 cm (about 1.2 inches).
• People whose cancer has spread in a way that raises concern for a specific type of spread along the lining of the brain (confirm with trial site).
• People who have bleeding within the tumour being studied.
• People who are receiving radiation after surgery to remove brain metastases or a primary head and neck cancer (adjuvant radiotherapy).
• People with a prior or current brain condition other than brain metastases, including stroke, brain bleeding, Alzheimer's disease or dementia, Parkinson's disease, Multiple Sclerosis, or schizophrenia.
• People who have previously had radiation treatment in an area that overlaps with the planned treatment area.
• People who are unable to have an MRI scan due to severe claustrophobia or because they have metal objects or implanted devices in their body, such as a pacemaker, surgical clips, metal fragments, certain implants, or tattoos near the imaging area.
• People who cannot have an MRI due to weight above 350 lbs (approximately 159 kg), which is a common weight limit for MRI equipment.
• People who have another existing condition that, in the judgement of the medical team, may increase health risks from participating.
• People who have a serious ongoing illness or psychiatric or social circumstances that may make it difficult to follow the study requirements.
• People who are under 18 years of age, or who are currently imprisoned.
• People who are currently breastfeeding, as the effects of the study imaging agent on infants are unknown.
• People who are pregnant, as the effects of the study imaging agent on an unborn baby are unknown. Pregnancy testing procedures apply to participants under 60 years of age, following the trial site's guidelines. People who decline pregnancy testing may be asked to sign a waiver confirming they are not known to be pregnant (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.