Phase 2 Long COVID Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older.
• People who have had a confirmed COVID-19 infection, shown by a positive PCR or antigen test.
• People who feel their memory or thinking has gotten worse since having COVID-19, as reported at the screening visit.
• People who show signs of cognitive (thinking or memory) difficulties at screening, based on a specific memory and thinking test called the MoCA, with a score below 26.
• Women who could become pregnant must be using effective contraception.
• People who provide written consent to take part in the trial.

Who may not be able to join:

• People with a known allergy or sensitivity to the study drug tianeptine.
• People with a known allergy or sensitivity to a substance called fluorodeoxyglucose (FDG), which is used in a type of brain scan.
• People with a history of significant drug or substance allergies that the trial doctor considers a reason not to participate.
• People who have had a stroke.
• People who have previously had brain surgery, or who have brain surgery planned during the study period.
• People with a previously diagnosed condition causing physical damage to the brain or nervous system.
• People diagnosed with an organic mental disorder (a mental health condition caused by a physical brain condition).
• People diagnosed with bipolar disorder.
• People diagnosed with a psychotic disorder.
• People with a history of a depressive episode, including one identified at the time of screening, that requires antidepressant medication.
• People diagnosed with an intellectual disability (previously called mental retardation).
• People who have a parent, sibling, or child diagnosed with bipolar disorder.
• People with uncontrolled diabetes.
• People with severe kidney disease, where kidney function (eGFR) is below 30 ml/min/1.73m².
• People with severe liver cirrhosis (the most advanced stage, known as Child-Pugh class C).
• People with claustrophobia (fear of enclosed spaces), as the trial involves scanning equipment.
• People with serious ongoing illnesses that, in the trial doctor's opinion, could significantly affect their health outcomes or ability to participate.
• People with an active cancer diagnosis or a cancer diagnosis within the past 5 years, except for certain treated skin cancers or cervical cancer in situ where full treatment has been completed.
• People with an active infection of any kind (viral, bacterial, fungal, tuberculosis, or parasitic).
• People with other medical conditions that, in the trial doctor's opinion, make participation unsuitable.
• Women of childbearing potential who have a positive pregnancy test at screening or the first visit.
• People who have taken certain medications recently, specifically non-selective MAO inhibitor drugs within 14 days before screening, or mianserin during the screening period.
• People who have significant difficulty with having a needle or cannula inserted into a vein.
• People with a history of alcohol, drug, or psychoactive substance misuse or dependence.
• People who are pregnant, or planning to become pregnant during the study.
• People who are breastfeeding, or planning to breastfeed during the study.
• People currently taking part in another clinical trial.
• People who, in the trial doctor's opinion, are unlikely to follow the trial requirements.

Important: Always verify eligibility with the trial site directly before applying.