Non-Alcoholic Fatty Liver Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a man or woman aged 20 or older who has been diagnosed with type 2 diabetes for at least 3 months
• You are currently taking standard diabetes medications (such as metformin, DPP-4 inhibitors, sulphonylureas, or insulin, alone or in combination) and your blood sugar control level (HbA1c) is below 9%
• You have been confirmed to have fat in your liver (detected by a special type of MRI scan showing more than 5.6% fat)
• You are in generally stable health based on your medical history, physical check-up, and blood tests
• You are willing and able to follow all the rules and requirements of the study
• You are willing to sign a consent form showing you understand and agree to take part

Who may not be able to join:

• You have a history of type 1 diabetes, diabetic ketoacidosis (a serious diabetes emergency), a pancreas or insulin cell transplant, or diabetes caused by a pancreas problem or surgery
• Your blood sugar levels are very unpredictable or difficult to control in a stable way
• You have had a problem with drug or alcohol misuse in the past 3 years, score above 8 on an alcohol screening test, or have regularly drunk more than moderate amounts of alcohol (20g/day for women or 30g/day for men) for at least 3 months in the past 5 years
• Your thyroid hormone level is too low or too high at the screening visit (confirm with trial site)
• You have used certain diabetes or metabolic medications — including pioglitazone, SGLT2 inhibitors (e.g. canagliflozin, empagliflozin, dapagliflozin), GLP-1 medications (e.g. liraglutide, dulaglutide), or saroglitazar — within the past 12 weeks
• Your BMI (body mass index) is over 40
• You have an eating disorder, or your weight has changed by 5% or more (up or down) in the past 12 weeks
• You have used weight loss medications or followed a formal weight loss programme recently (within the past 3–12 months)
• You have kidney disease that needed immunosuppressive treatment, or you have had dialysis or a kidney transplant
• You have had a heart attack, unstable chest pain, stroke, or certain heart or blood vessel procedures within the past 3 months, or you have been diagnosed with advanced heart failure (NYHA Class III or IV)
• You have or have had hepatitis B, hepatitis C, or another active liver disease
• You have used vitamin E supplements within the past 12 weeks
• You have previously had bariatric (weight loss) surgery or major upper digestive tract surgery
• You have a history of delayed stomach emptying (gastroparesis), poor nutrient absorption, inflammatory bowel disease, or another significant long-term gut condition
• Your kidney filtering function (measured by a blood test called eGFR) is below 60 (confirm with trial site)
• You have any metal objects in your body or any other reason you cannot safely have an MRI scan
• You experience claustrophobia or anxiety about MRI scans, or you are unwilling to have MRI scans
• You have a significant blood disorder (such as severe anaemia or low platelet count) at the time of screening
• You have tested positive for HIV
• You have had major surgery (requiring general anaesthesia) in the past 12 weeks, have not fully recovered from surgery, or are planning surgery during the study period
• You have any medical reason that means you should not take the study drug, bempedoic acid (confirm with trial site)
• You are currently taking or are likely to need steroid medications or immunosuppressive drugs

Important: Always verify eligibility with the trial site directly before applying.