Cystic Fibrosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older
• People who have never smoked, or who smoked very little (fewer than 10 pack-years total) and have not smoked at all in the past year
• People who have been diagnosed with cystic fibrosis through standard testing (such as a sweat test, physical features, or genetic testing)
• People who do not use supplemental (extra) oxygen
• People whose lung function has been stable — within 10% of their personal best over the last 6 months, with no lung infection flare-ups in the past 4 weeks, and a breathing test result (FEV1) of at least 60% of what is expected for their age and size
• People who have read and signed a consent form showing they have been fully informed about the trial
• People who are willing and able to attend scheduled visits and follow the trial procedures

Who may not be able to join:

• People who currently smoke or vape, or who quit less than one year ago, or who have a smoking history of more than 10 pack-years
• People who are unable to have a 3.0-Tesla MRI scan of the lungs and chest due to safety concerns, including any of the following:
  • Current or past work as a machinist, welder, or grinder
  • A past eye injury involving a metal object
  • A past body injury from a metal object such as a bullet or shrapnel
  • Having a heart pacemaker or defibrillator
  • Having aneurysm clips in the brain or body
  • Having a carotid artery vascular clamp
  • Having a neurostimulator device
  • Having an insulin pump or infusion pump
  • Having an implanted drug delivery device that is not confirmed to be MRI-safe (for example, one placed at another facility or more than 10 years old)
  • Having a bone growth or fusion stimulator
  • Having a cochlear implant or other ear implant
  • Having any type of prosthesis (such as an eye or penile prosthesis)
  • Having an artificial limb or joint
  • Having non-removable electrodes on the body, head, or brain
  • Having stents, filters, or coils inside blood vessels
  • Having a spinal or brain fluid shunt
  • Having a Swan-Ganz catheter
  • Having any implant held in place by a magnet
  • Using a patch-based medication delivery system (such as a nitroglycerin skin patch)
  • Having an intrauterine device (IUD) or diaphragm that is not MRI-safe
  • Having permanent cosmetic tattooing (such as tattooed eyeliner or lip liner), or tattoos covering more than 25% of the body
  • Having body piercings that cannot be removed before the MRI
  • Having any metal fragments in the body
  • Having internal pacing wires
  • Having metal or wire mesh implants
  • Having a hearing aid that cannot be removed before the MRI
  • Having dentures that cannot be removed before the MRI
  • Having claustrophobia (fear of enclosed spaces)
• People who are unable to breathe in the gas mixture used during the scan
• People who have facial hair that could prevent the breathing mask from fitting properly, and who are unwilling to shave before each MRI session
• People who have had any changes to their cystic fibrosis medications — including experimental treatments — in the past 28 days
• People with another serious medical or psychiatric condition, or abnormal lab results, that the trial doctor believes could make participation unsafe or affect the trial results
• People who are pregnant; women who could become pregnant will need to have a confirmed negative pregnancy test on the day of each MRI scan, taken before the scan begins

Important: Always verify eligibility with the trial site directly before applying.