Phase 2 Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with a specific type of epilepsy called mesial temporal lobe epilepsy (MTLE) that affects only one side of the brain and has not responded to medication.
• People who have had at least 2 seizures per month (of specific types — either seizures involving loss of awareness, or seizures that spread to affect the whole body) on average over the past 3 months, with records to confirm this.
• People who have been on a stable type and dose of up to 4 approved seizure medications for at least 1 month before that 3-month period.
• People who have confirmed abnormality in one specific brain structure (the hippocampus) on only one side of the brain, with scan results that match where the seizures are coming from.
• People whose thinking and memory difficulties, if any, are consistent with what their brain scans show — and not unexpectedly different from what the disease would explain.
• People who are able and willing to use highly effective contraception consistently throughout the study (applies to women who could become pregnant and men who could father a child).
• Women who could become pregnant must have a negative pregnancy test before joining.

Who may not be able to join:

• People who have an implanted device (such as a pacemaker) that is not safe for MRI scans, or whose MRI-compatible device was implanted less than 3 months before the screening visit (devices like vagus nerve stimulators may be considered on a case-by-case basis by the trial doctor).
• People who have any medical reason that would make general anaesthetic, surgery, or MRI during surgery unsafe.
• People taking certain medications (for example, some antipsychotic or antiviral drugs) that could interfere with test results, affect safety, or affect the ability to undergo the surgical procedure or follow the trial schedule.
• People whose epilepsy affects both sides of the brain, multiple areas, or whose doctors cannot clearly identify which side the seizures start from.
• People who have dementia or other progressive neurological conditions, or a brain lesion that is growing or worsening.
• People who have previously had major brain surgery unrelated to their epilepsy (such as for a brain tumour, head injury, or bleeding), or who have previously had brain surgery to treat epilepsy (note: diagnostic depth electrode monitoring is not counted as an exclusion).
• People whose MRI scans show seizure-related abnormalities outside the temporal lobe, or abnormalities in both temporal lobes.
• People who have had a prolonged, dangerous seizure episode (status epilepticus) within the year before the screening visit.

Important: Always verify eligibility with the trial site directly before applying.