Phase 2 Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with a specific type of brain tumour called glioblastoma (GBM, IDH-wildtype), confirmed by a tissue test
• Your brain tumour has come back for the first or second time after you received radiation therapy and a chemotherapy drug called temozolomide (TMZ)
• Tissue samples from your original tumour diagnosis are available for testing
• Your blood counts and organ function (kidneys, liver, and blood clotting) are within acceptable ranges, as measured by blood tests (confirm with trial site)
• You are well enough to carry out most daily activities, as measured by a standard health scale called the Karnofsky Performance Status (confirm with trial site)
• You are not able to become pregnant, or you agree to use an approved and reliable form of contraception during the trial and for 5 months after your last dose of treatment
• You are able to read, understand, and sign a consent form agreeing to take part in the study
• You have tested negative for HIV, or if positive, your HIV is well controlled with medication, with a CD4 count above 200 and an undetectable viral load
• You have tested negative for active Hepatitis B infection (based on specific blood tests)
• You have tested negative for active Hepatitis C infection (based on specific blood tests)

Who may not be able to join:

• You are currently pregnant, breastfeeding, or planning to become pregnant during the trial or within 5 months of your last dose of treatment
• You have previously received any form of immunotherapy treatment
• You received a drug called bevacizumab within 4 weeks before your biopsy
• You have taken immune-suppressing medications (such as steroids above a low dose, or certain other drugs) within the past 2 weeks, or are expected to need them during the trial — with some exceptions for certain low-dose or short-term uses (confirm with trial site)
• You have had a severe allergic reaction to certain types of laboratory-made antibody treatments in the past
• You have a known allergy to any ingredient in the study drug (atezolizumab), including products derived from Chinese hamster ovary cells
• You have an active autoimmune disease or immune deficiency — though some conditions such as well-controlled thyroid problems, Type 1 diabetes on insulin, or mild skin conditions may still be eligible (confirm with trial site)
• It has been fewer than 12 weeks since you finished radiation therapy, unless your tumour is clearly growing (confirm with trial site)
• You have a medical reason that makes surgery unsafe for you
• You have had a significant heart problem, heart attack, or stroke within the past 3 months, or you have an unstable heart condition
• You have had major surgery (not including a diagnostic biopsy) within the past 4 weeks, or are expected to need major surgery during the trial
• You have had another cancer diagnosed within the past 12 months, with some exceptions for certain low-risk or well-treated cancers (confirm with trial site)
• You had a serious infection within the past 4 weeks, or currently have an active infection
• You have received a live vaccine within the past 4 weeks, or expect to need one during the trial or within 5 months of your last dose
• You have taken part in another experimental treatment study within the past 28 days
• You have previously received certain types of immunotherapy drugs, including checkpoint inhibitor treatments (such as anti-PD-1, anti-PD-L1, or anti-CTLA-4 therapies)
• You have uncontrolled fluid build-up around your lungs, heart, or abdomen that needs to be drained frequently (more than once a month)
• You have uncontrolled high calcium levels in your blood
• You currently have active tuberculosis (TB)
• You have a history of certain lung conditions, such as pulmonary fibrosis or drug-related lung inflammation, or you currently have active lung inflammation
• You have been on antibiotic treatment (not just preventative antibiotics) within the past 2 weeks
• You have previously had a stem cell transplant or an organ transplant from another person

Important: Always verify eligibility with the trial site directly before applying.