Phase 2 Multiple Sclerosis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Children and teenagers between 8 and 17 years old who are not currently staying in a hospital
• Girls who could become pregnant, are sexually active, and agree to use an approved form of birth control during the study and for at least one week after the last dose of study medication
• Young people who have been diagnosed with Autism Spectrum Disorder (ASD), ADHD, Tic Disorders, Fragile X syndrome, tuberous sclerosis, or a 22q11 deletion
• Young people who also have a diagnosed anxiety disorder, such as Separation Anxiety, Social Anxiety, Agoraphobia, Generalized Anxiety Disorder, or another anxiety condition identified through a clinical interview
• Young people whose anxiety is rated as at least "moderately severe" by a clinician using a standard rating scale
• Young people who can speak at least in short phrases — there is no minimum IQ requirement for this trial
• Young people already taking behaviour-affecting medications, as long as the dose has been stable for at least one month before the study and will not be changed during the study
• Young people already receiving non-medication behavioural support, as long as it has been stable for at least three months before the study and will not be changed during the study
• Young people (or their caregivers) who are able to complete assessments in English or French

Who may not be able to join:

• Young people who have taken another type of antidepressant medication called an SSRI within the past four weeks (or six weeks for fluoxetine specifically)
• Young people who have previously tried sertraline (the study medication) at an adequate dose and either had no improvement or experienced significant side effects
• Young people who have already tried more than two different SSRI medications without adequate benefit
• Girls who are pregnant or sexually active without using adequate birth control
• Young people with a serious medical condition that the study doctor believes could interfere with the study or put them at risk; this includes people with diabetes who take medication to control blood sugar levels
• Young people who are allergic to sertraline or any of its ingredients
• Young people currently taking certain other medications, including a type called MAO inhibitors or a medication called pimozide
• Young people taking other medications known to significantly affect heart rhythm in a way the study doctor considers unsafe
• Young people with a known inherited condition that causes a heart rhythm problem called long QT syndrome
• Young people with certain health conditions including HIV, hepatitis B or C, hemophilia, abnormal blood pressure, substance misuse, immune system disorders, a current major depressive episode, or psychosis
• Young people who are unable to tolerate having a blood sample taken by needle
• Young people who are unable to swallow capsules
• Young people who are currently enrolled in another intervention research study

Important: Always verify eligibility with the trial site directly before applying.