Phase 3 Leukaemia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 50 to 70 years old.
• People aged 50 to 55 who have been assessed as not fit enough for the most intensive type of stem cell transplant preparation (based on a health scoring system called SORROR, with a score of 2 or higher).
• People diagnosed with a blood cancer called AML (acute myeloid leukaemia) that requires a stem cell transplant from a donor, where the disease is currently in remission (no cancer cells detectable), or people diagnosed with a bone marrow condition called MDS (myelodysplastic syndrome) that requires a donor stem cell transplant and meets certain severity thresholds (confirm with trial site).
• People who do not have a closely matched family member available as a stem cell donor.
• People who have an identified closely matched unrelated donor (matched at 10 out of 10 points on a tissue-matching scale).
• People whose general health meets standard requirements for a stem cell transplant, including: being reasonably functional day-to-day (ECOG score of 2 or less); having no severe uncontrolled infection; having adequate heart function (pumping at least 50% efficiency); having adequate lung function (above a certain breathing test threshold); and having adequately functioning liver and kidneys (confirm specific values with trial site).
• People who have health insurance coverage.
• People who have read and signed a written consent form agreeing to take part.
• People who are willing to use an approved contraception method for the full duration of the trial — this applies to women of childbearing age (including options such as hormonal contraception or an intrauterine device) and to men (including condoms or abstinence, where abstinence reflects their usual lifestyle).

Who may not be able to join:

• People who have had another cancer in the past 5 years (except certain very early-stage or minor skin or cervical cancers).
• People with an active, uncontrolled infection.
• People who test positive for HIV, HTLV-1, or who have active hepatitis B or C.
• People who have received a yellow fever vaccine or any other live virus vaccine within 2 months before the transplant.
• People with heart failure of a certain severity, or whose heart pumping function is below 50%.
• People whose lung function falls at or below a certain breathing test threshold.
• People who already have a bladder condition involving bleeding (acute haemorrhagic cystitis).
• People whose kidneys are not functioning well enough (below a certain filtration rate threshold).
• People who are pregnant or breastfeeding.
• People with a serious medical or psychiatric condition that would prevent them from safely undergoing the transplant or from understanding the trial.
• People receiving a particular type of government-funded medical assistance (state medical aid, as defined in the trial country).
• People who are under a legal protection order, guardianship, or curatorship.
• People who have a known allergy to any of the main trial medications, including the anti-rejection medicines or any other drugs planned for use in the trial (confirm specific medications with trial site).
• People who are currently participating in another interventional clinical trial.

Important: Always verify eligibility with the trial site directly before applying.