Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with non-small cell lung cancer (NSCLC) that is at an advanced local stage (Stage III) and cannot be removed by surgery, confirmed by a tissue or cell sample
• Your cancer shows a certain protein marker (PD-L1) present in at least 1% of tumor cells, confirmed by a standard lab test
• Doctors have agreed, as a team, that you are suitable for combined chemotherapy with radiation followed by immunotherapy
• You are generally in good physical health and able to carry out daily activities with little to no limitation (based on a standard doctor's rating scale of 0 or 1)
• You have had a specific type of full-body scan (FDG-PET CT) within the last 21 days before starting treatment
• Your lung function tests meet the minimum required levels (confirm with trial site for exact values)
• Your blood counts, liver function, and kidney function are all within acceptable ranges (confirm with trial site for exact values)
• You weigh more than 30 kg
• If you are a woman who could become pregnant, you have had a negative pregnancy test before joining
• You agree to use highly effective contraception throughout the treatment and for at least 90 days after the last immunotherapy dose or 6 months after the last chemotherapy dose, whichever is later (applies to both women who could become pregnant and men whose partners could become pregnant)
• You are willing and able to attend all scheduled visits and follow the study requirements
• You have given written consent to take part

Who may not be able to join:

• Your lung cancer is a mixed type involving small cell lung cancer, or is a neuroendocrine tumor
• Your cancer has spread to other parts of the body (distant metastases)
• You have fluid around your lungs or heart caused by cancer
• You have a blockage of a major vein in your chest (superior vena cava obstruction)
• You have previously had treatment for this NSCLC, such as surgery, radiotherapy, chemotherapy, or immunotherapy (a limited exception may apply for early-stage NSCLC treated in the past — confirm with trial site)
• You have received a live vaccine within the 30 days before starting treatment
• You have had a major surgical procedure within 28 days before starting treatment
• You have previously received immunotherapy drugs such as checkpoint inhibitors (e.g., anti-PD-1, anti-PD-L1, anti-CTLA-4 treatments, or cancer vaccines)
• You are currently taking strong immune-suppressing medications on a long-term basis (some exceptions, such as low-dose steroids or inhaled/topical steroids, may apply — confirm with trial site)
• You have previously had an organ transplant from another person
• You have an active or past autoimmune or inflammatory condition such as lupus, Crohn's disease, rheumatoid arthritis, or similar disorders (some exceptions may apply — confirm with trial site)
• You have another serious illness that is not well controlled, such as an active infection, heart failure, uncontrolled high blood pressure, or a serious mental health condition
• You require oxygen to breathe
• You have active swollen lymph nodes in your chest related to certain lung conditions such as silicosis, sarcoidosis, or tuberculosis
• You have or have had another type of cancer within the past 2 years (some exceptions for certain skin cancers or early-stage cancers fully treated more than 2 years ago may apply — confirm with trial site)
• You have a history of cancer spreading to the lining around the brain or spinal cord
• You have tested positive for hepatitis B, hepatitis C, tuberculosis, or HIV
• You have a known allergy to any of the study medications, including durvalumab or the chemotherapy drugs used in this trial
• You have a type of lung tumor (such as Pancoast or superior sulcus tumors) that doctors are planning to treat with surgery
• You are currently enrolled in another clinical trial involving an experimental treatment
• You have taken part in another clinical trial with an experimental drug within the 4 weeks before joining this study
• You are pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.