Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to take part voluntarily and have signed a consent form
• Adults over 18 years old, of any gender
• People with advanced non-small cell lung cancer (a type of lung cancer) that cannot be removed by surgery or has spread to other parts of the body (stage IIIB, IIIC, or IV), confirmed by a tissue or cell sample, and with a specific genetic change called EGFR exon 21 L858R mutation
• People who have at least one measurable tumour that can be tracked during the trial, based on standard medical imaging guidelines
• People with a physical functioning score of 0 to 3 on a standard scale used by cancer specialists (this ranges from fully active to limited self-care ability — confirm with trial site)
• People whose doctors expect them to live for more than 3 months
• People who have not previously received any cancer treatment, including chemotherapy, radiation, targeted therapy, or immunotherapy
• People whose blood and organ function test results meet specific minimum levels within 7 days before starting treatment, including: adequate red blood cells, white blood cells, and platelets (without a blood transfusion in the 14 days before testing); liver enzyme and bilirubin levels within acceptable ranges; and kidney function within acceptable ranges

Who may not be able to join:

• People whose lung cancer contains a mix of different cancer cell types
• People with poorly controlled blood pressure (top number 150 or above, or bottom number 100 or above)
• People where scans show the tumour is growing into or very close to major blood vessels, raising the risk of serious bleeding
• People who have had a blood clot, stroke, or related event (such as deep vein thrombosis or pulmonary embolism) in the past 6 months
• People who have difficulty swallowing, have had part of their stomach or bowel removed, have ongoing severe diarrhoea, or have a bowel blockage that could affect taking oral medication
• People who have brain metastases (cancer that has spread to the brain) that are causing symptoms
• People who have had a serious heart condition — such as a heart attack, unstable chest pain, heart failure, or severe uncontrolled irregular heartbeat — within the 6 months before joining
• People with an active or uncontrolled serious infection
• People with severe liver disease, cirrhosis, or active hepatitis
• People whose urine tests show high levels of protein (confirmed by a 24-hour urine collection showing more than 1.0g of protein)
• People with active tuberculosis
• Women who are pregnant or breastfeeding
• People who, in the judgement of the medical team, have other serious conditions (including mental illness), significant abnormal test results, or personal or social circumstances that could affect their safety or the quality of the trial data

Important: Always verify eligibility with the trial site directly before applying.