Phase 2 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have signed a written consent form before any trial procedures begin.
• You have been diagnosed with osteosarcoma (a type of bone cancer) that has spread to the lungs, confirmed by a tissue biopsy, and you do not currently have the cancer returning at the original bone site (though previous surgery to remove a local recurrence with clear margins is allowed).
• The spots on your lungs can be surgically removed by taking out a small portion of lung tissue, and there is no cancerous fluid around your lungs.
• You have already received at least one standard cancer treatment, and you have never previously been treated with a drug called gemcitabine.
• Your lungs are healthy enough to undergo one or two surgeries on your chest.
• You are between 10 and 65 years old.
• If you are 16 or older, your general physical ability and daily functioning falls within an acceptable range on a standard medical scale (including people with amputations who can mostly care for themselves and move around more than half of their waking hours with aids such as a walker or wheelchair).
• If you are under 16, your ability to carry out daily activities meets a minimum acceptable level on a scale used for children (including children with amputations who can still take part in most activities with the help of a walker or wheelchair).
• Your doctors expect you to live for more than 24 weeks.
• Most of your returning cancer spots can be treated with a focused type of radiation therapy called SBRT (stereotactic body radiotherapy).
• Your major organs (such as heart, liver, and kidneys) are working at a safe enough level, as confirmed by tests done 7–14 days before treatment starts.
• If you are a woman who could become pregnant, you agree to use reliable contraception during the study and for 6 months afterward, you have tested negative for pregnancy within 7 days of starting the study, and you are not currently breastfeeding; if you are male, you agree to use contraception during the study and for 6 months afterward.
• If you have spots on your lungs that were previously treated with surgery, a heat-based procedure (radiofrequency ablation), or radiation, you may still be eligible depending on whether those spots have stayed stable or grown — the trial team will assess this on a case-by-case basis (confirm with trial site).

Who may not be able to join:

• You have been diagnosed with another cancer (other than the one being studied) within the past 5 years.
• You are currently taking part in another clinical trial, or you have received an experimental drug or used experimental medical equipment within the past 4 weeks.
• You have previously been treated with certain types of immunotherapy drugs (such as anti-PD-1, anti-PD-L1, anti-PD-L2, or similar immune-targeting drugs), and your cancer eventually stopped responding to that treatment after initially working.
• You have taken certain Chinese herbal medicines with anti-cancer effects, or drugs that affect the immune system (such as thymosin, interferon, or interleukin), within the past 2 weeks — except when used locally to treat fluid around the lungs.
• You have had an active autoimmune disease (where your immune system attacks your own body) requiring ongoing medical treatment within the past 2 years — note that simple hormone replacement therapies are not counted as exclusions.
• You are currently taking steroid tablets or injections, or other medicines that suppress your immune system, within 7 days before starting the trial (steroid nasal sprays, inhalers, or creams are not counted).
• You have previously had an organ transplant from another person (except a cornea transplant), or a stem cell transplant from another person.
• You have a known severe allergy (grade 3 or higher) to any ingredient in monoclonal antibody medicines.
• You have not yet fully recovered from side effects of any previous cancer treatment (confirm with trial site).
• You are known to be HIV-positive.
• You have received a live vaccine within the past 30 days before starting the trial.
• You are currently pregnant or breastfeeding.
• You have any serious or uncontrolled illness affecting your whole body (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.