Phase 2 Leukaemia Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• The participant (and/or their legal guardian, if applicable) must have given written consent to take part in the study
• Stored tumour tissue from a previous biopsy must be available for use, though exceptions may be considered with approval from the lead researcher
• Participants must be between 2 and 22 years old
• Participants must weigh at least 25 kg (approximately 55 pounds)
• Participants must have a general health and activity level rated as reasonably functional, based on standard medical scoring tools (confirm with trial site for exact scores)
• Participants must be a suitable candidate for a bone marrow transplant and have a matching donor — either a related family member or an unrelated donor with a close enough genetic match — who is willing to donate bone marrow or stem cells
• Participants must have a diagnosis of acute leukaemia (either AML or ALL) that is currently in complete remission, or a diagnosis of myelodysplastic syndrome (MDS)
• Participants must have recovered from the side effects of any previous cancer treatment (with the exception of hair loss), with only mild or no remaining effects
• Female participants who could potentially become pregnant must have a negative pregnancy test result within 30 days before starting treatment
• All participants who could potentially father or become pregnant must agree to use effective contraception or avoid sexual activity for the duration of the study and for at least 6 months after the last dose of treatment

Who may not be able to join:

• People who received an autologous stem cell transplant (using their own cells) within the past year
• People who have previously received an allogeneic transplant (using a donor's cells)
• People who have received chemotherapy, radiation, biological therapy, or immunotherapy within the 14 days before starting the study (note: standard pre-transplant conditioning treatment and certain maintenance chemotherapy may not automatically disqualify someone — confirm with trial site)
• People who are currently using herbal medicines or supplements
• People with a history of serious allergic reactions to substances chemically similar to the study treatment
• People with a history of active tuberculosis
• People who have experienced a blood clot-related event — such as a heart attack, stroke, pulmonary embolism, or deep vein thrombosis — within the past 6 months
• People with ongoing diarrhoea caused by inflammatory bowel disease or a condition affecting nutrient absorption
• People with a significant uncontrolled medical illness
• People with an active, uncontrolled infection (viral, bacterial, or fungal) that requires antibiotics or antifungal treatment
• People with a known history of HIV, hepatitis B, or hepatitis C
• People with another active cancer diagnosis
• Females who are pregnant or currently breastfeeding
• People with any other condition that, in the treating doctor's judgment, would make participation unsafe
• People who, in the opinion of the investigator, may have difficulty following all study procedures and requirements

Important: Always verify eligibility with the trial site directly before applying.