Non-Alcoholic Fatty Liver Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older (any gender)
• Your body mass index (BMI) is 30 or above, OR your BMI is 27 or above and you have at least one health condition related to your weight (such as high blood pressure or type 2 diabetes)
• Your weight has been stable (no more than 5% change) for the 6 months before your first visit
• You are willing to follow all study requirements, including signing a consent form, attending follow-up visits, completing tests, and participating in diet counseling
• You are willing to not start any new weight-loss medications for the next 12 months
• You live close enough to the trial site to attend regular follow-up visits
• You are able to understand and sign a consent form agreeing to take part
• If you are a woman who could become pregnant, you must agree to use a reliable form of birth control during the trial

Who may not be able to join:

• You have a known history of other long-term liver diseases, such as viral hepatitis, autoimmune hepatitis, drug-related hepatitis, or inherited liver conditions
• You have taken certain medications (vitamin E at high doses, pioglitazone, obeticholic acid, or resmetirom) in the 90 days before your first visit
• You have had previous surgery on your stomach or digestive tract (except for certain simple procedures like gallbladder removal or appendix removal)
• You have had weight-loss (bariatric) surgery in the past
• You have had a previous endoscopic sleeve gastroplasty (a non-surgical stomach-reducing procedure)
• You have any inflammatory condition of the digestive tract, such as severe acid damage to the esophagus, Barrett's esophagus with abnormal cells, stomach or small intestine ulcers, cancer, or Crohn's disease
• You have conditions that could cause serious bleeding in your upper digestive tract, such as enlarged veins in the esophagus or stomach, or certain abnormal blood vessel growths
• You have severe acid reflux (GERD)
• You have a structural problem in your esophagus or throat (such as a narrowing or pouch) that could make it difficult to pass a medical scope through
• You have achalasia or another serious condition affecting how your esophagus moves food
• You experience chronic (ongoing) abdominal pain
• You have gastroparesis (slow stomach emptying) or very persistent constipation
• You have significant liver failure or cirrhosis (severe liver scarring)
• You have a serious blood clotting disorder
• You have insulin-dependent diabetes (type 1 or type 2), are likely to need insulin in the next 12 months, or have very poorly controlled blood sugar (HbA1c of 12% or higher)
• You regularly take blood-thinning medications, anti-platelet drugs, or anti-inflammatory painkillers (NSAIDs)
• You regularly take steroids, immunosuppressants, or strong prescription pain medications (narcotics)
• You take anti-seizure or heart rhythm medications
• You are currently pregnant or breastfeeding
• You drink more than a moderate amount of alcohol (more than 20g per day for women or 30g per day for men) (confirm with trial site for exact amounts)
• You are currently an active smoker
• You have a history of poorly controlled high blood pressure, coronary artery disease, heart failure, or irregular heart rhythm
• You have a history of certain serious breathing conditions such as COPD requiring steroid treatment, pneumonia, or lung cancer
• You have a history of autoimmune conditions such as lupus or scleroderma, or a weakened immune system
• You currently have an active cancer
• Your obesity is caused by a genetic or hormonal condition, such as Prader-Willi syndrome
• You have an uncontrolled hormonal disorder affecting your weight, such as uncontrolled underactive thyroid
• You have an eating disorder, such as bulimia, binge eating disorder, night eating syndrome, or compulsive overeating
• You have active mental health conditions that, as assessed by a psychologist, would prevent you from taking part in a lifestyle change program

Important: Always verify eligibility with the trial site directly before applying.