Phase 3 Lung Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have agreed to take part and given written consent before any study procedures begin
• You have been diagnosed with non-small cell lung cancer (NSCLC), confirmed by a tissue or cell sample
• Your cancer is at stage IV (spread to other parts of the body) but has spread to 5 or fewer spots outside the main tumour and nearby lymph nodes
• Your doctors consider you well enough to receive standard first-line cancer drug treatment (such as chemotherapy, immunotherapy, or a combination)
• The cancer spots that have spread outside the chest area can be treated with a precise, targeted type of radiotherapy called SBRT
• The tumour(s) in your chest can also be treated with SBRT or standard radiotherapy
• You have not had any previous drug treatment or radiotherapy for this lung cancer (though previous treatment given after surgery for an earlier stage is allowed)
• You are over 18 years old (there is no upper age limit)
• You are generally well enough to carry out most daily activities (measured on a standard scale called WHO performance status 0–2)
• Your major organs (such as kidneys, liver, and bone marrow) are working well enough for treatment
• If you are a woman who could become pregnant, you have tested negative for pregnancy before joining
• You are willing and able to attend all required appointments and follow-up visits throughout the study

Who may not be able to join:

• Your cancer has spread only to a single spot in the brain, or only to the opposite lung, with no other distant spread
• You have taken part in another clinical trial using an experimental treatment within the last 4 weeks
• Your lung cancer has a specific genetic change (such as EGFR+, ALK+, or ROS1+) or any other gene alteration that means your standard treatment would be a targeted therapy pill (TKI), rather than chemotherapy or immunotherapy
• You have cancer cells in fluid around your lungs or abdomen, or excessive fluid that would make the planned radiotherapy unsafe
• The cancer has spread to the lining around the brain and spinal cord (leptomeningeal disease)
• You have significant scarring in the lungs (pulmonary fibrosis) that would make the planned treatment too risky (minor findings on scans may still be acceptable — confirm with trial site)
• You are not considered fit enough for standard first-line cancer drug treatment
• You currently have, or have recently had, another type of cancer — some exceptions may apply, such as certain low-risk or previously treated cancers; confirm details with the trial site
• You are pregnant, breastfeeding, or are unwilling to use reliable contraception from the start of the study until 90 days after your last dose of treatment (applies to both men and women of reproductive age)
• You have any other medical condition that, in the opinion of the study doctor, could affect your safety or interfere with the study results (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.