Phase 2 Interstitial Lung Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 2 years or older who have been diagnosed with a histiocytic disorder (a rare disease affecting certain immune cells) that needs treatment throughout the body.
• People whose diagnosis has been confirmed through a tissue sample (biopsy) reviewed by a specialist pathologist, or who have tissue available for genetic testing if genetic testing has not yet been done.
• People with disease only in the pituitary gland or brain where a biopsy is not possible, provided a specific blood test shows a gene mutation linked to this type of disease along with matching clinical signs.
• People who have measurable signs of their disease visible on a PET scan or brain MRI.
• People whose kidneys, liver, and blood counts are working at a minimum level as determined by specific lab tests (confirm exact values with trial site).
• People whose organ function falls outside the normal ranges listed, if the trial doctors determine this is caused directly by the histiocytic disease itself.

Who may not be able to join:

• People who have received certain types of chemotherapy that affect bone marrow cell growth (such as cytarabine, cladribine, clofarabine, mercaptopurine, methotrexate, or vinblastine) within the 14 days before joining the trial.
• People who have taken a MEK inhibitor medication within 30 days (or longer, depending on the specific drug) before joining, or whose disease got worse while taking a MEK inhibitor.
• People who have used steroid medications (by mouth, inhaled, or as eye drops) within 14 days before starting the trial drug, or who need to take steroids for more than 30 days in a row during the study — except people who need low-dose steroids because their body does not produce enough hormones naturally.
• People who have received radiation therapy within 14 days before joining, or who have ever received radiation to the eye area at any time.
• People who have certain risk factors for a serious eye condition called retinal vein occlusion, including high eye pressure, uncontrolled glaucoma or significant eye abnormalities, very high cholesterol (above 300 mg/dL), very high triglycerides (above 300 mg/dL), high blood sugar, or uncontrolled high blood pressure (confirm specific thresholds with trial site).
• People whose heart pumping function is below 55% on a heart scan, or who have a significant heart condition, unless it is directly caused by the histiocytic disease.
• People who are pregnant, breastfeeding, at risk of becoming pregnant, or at risk of fathering a child and are unable or unwilling to use an acceptable form of birth control for the duration of the study.

Important: Always verify eligibility with the trial site directly before applying.