Phase 3 Head and Neck Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Your nasopharyngeal carcinoma (a type of head and neck cancer) has come back or spread, confirmed by a tissue or cell test
• You have not previously received systemic (whole-body) treatment for the recurrent or spread cancer — though if you had chemotherapy before, you may still qualify if it ended at least 6 months ago
• You are between 18 and 75 years old (male or female)
• You are generally well enough to carry out light activity and care for yourself (a doctor will assess this)
• You have at least one tumour that can be measured on a scan, meeting specific size requirements (confirm with trial site)
• Your blood counts are within acceptable levels, including red blood cells, white blood cells, and platelets (confirmed by a blood test)
• Your liver and kidney function test results are within acceptable ranges (confirmed by blood tests)
• Your blood clotting results are within acceptable ranges
• If you could become pregnant, you agree to use contraception and have had a negative pregnancy test within 2 weeks before joining
• You are willing to provide a small sample of tumour tissue (such as stored tissue slides or a wax block)
• You are expected to live for at least 3 more months
• You are willing to take part and have signed a consent form

Who may not be able to join:

• Your cancer has come back in one area only and could be treated with surgery or radiotherapy
• You have had a serious allergic reaction to monoclonal antibody treatments in the past
• You have previously been treated with certain immunotherapy drugs (PD-1, PD-L1, or CTLA-4 antibodies)
• You have significant heart problems, such as severe heart failure, unstable chest pain, a heart attack within the last 6 months, or certain abnormal heart rhythms
• You have an autoimmune disease requiring treatment, or have used steroids or immune-suppressing medicines long-term for conditions such as thyroid problems, lung inflammation, or colitis
• You have uncontrolled diabetes or certain serious lung conditions
• You have active hepatitis B, hepatitis C, HIV, or another condition that weakens your immune system
• You currently have a severe active infection
• Your cancer has spread to the brain and is causing symptoms
• You have had another type of cancer in the past, unless you were fully cured more than 5 years ago
• You have a serious neurological or psychiatric condition, such as dementia or epilepsy
• You have a history of drug misuse or other personal circumstances that could affect your participation in the study
• The trial doctors have another reason they feel you are not suitable (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.