Phase 2 Bladder Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are female and at least 18 years old
• People who have been diagnosed with urothelial carcinoma (a type of bladder cancer), confirmed by a tissue sample, including certain variations of this cancer type
• People who are considered suitable candidates for a major bladder removal surgery called radical cystectomy
• People who are able to have a pelvic MRI scan meeting specific technical standards (including use of a 1.5 Tesla or stronger scanner, certain imaging sequences, and contrast dye unless there is an allergy or kidney concern)
• People who have had a camera examination of the bladder (cystoscopy) performed by a urologist within the 120 days before surgery
• People who have had staging scans (to assess cancer spread) within 90 days before surgery — and if chemotherapy or other treatment was given beforehand, repeat staging scans must be done after that treatment is finished or stopped
• People whose staging scans include a pelvic MRI within 90 days of surgery
• People who are willing and able to follow all study procedures and have provided written consent to participate
• People who still have at least one of the following organs present: the front wall of the vagina, uterus, fallopian tube(s), or ovaries
• People with a general health and activity level rated 0, 1, or 2 on a standard medical scale (meaning they are fully active to somewhat limited but able to care for themselves)

Who may not be able to join:

• People whose cancer has spread to nearby lymph nodes or to other parts of the body
• People whose bladder cancer is not of the urothelial type
• People who are not considered suitable for radical cystectomy surgery
• People who are unable to have a pelvic MRI that meets the required technical standards
• People who are capable of becoming pregnant and are unwilling or unable to use an acceptable form of contraception during the study and for at least 12 weeks after the study procedure
• People who have another known active cancer that could affect the study results
• People who have known inherited mutations in certain genes related to DNA repair (BRCA1 or BRCA2)
• People who are prisoners or who are held in a facility against their will
• People who are legally required to receive treatment for a psychiatric or physical condition
• People who are unlikely to be able to follow the study schedule and procedures
• People who are confirmed to be pregnant or are currently breastfeeding
• People with another illness, health condition, or medical finding that the treating doctor believes could make participation unsafe or affect the study results
• People who have received a live virus vaccine within the 30 days before the study procedure (for example, the nasal spray flu vaccine — most standard injected flu vaccines and non-live COVID vaccines are generally not affected by this rule, but confirm with the trial site)

Important: Always verify eligibility with the trial site directly before applying.