Phase 1 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

To donate cells (Procurement phase):

• People aged 21 years or older
• People who have a solid tumour that tests positive for a protein called GPC3, confirmed by a specific laboratory test showing a sufficient amount of the protein in tumour cells
• People whose general health and ability to perform daily activities meets a minimum score on a standard health scale (Lansky or Karnofsky score of 60% or above)
• People with a life expectancy of at least 16 weeks
• People with liver cancer (hepatocellular carcinoma) whose disease falls within a certain stage range (Barcelona Clinic Liver Cancer Stage A, B, or C) and whose liver function score is below a certain threshold (confirm with trial site)
• People, or their legal guardian, who have been fully informed about the trial and have signed a consent form

To receive treatment (Treatment phase):

• People aged 21 years or older with a GPC3-positive solid tumour
• People whose general health meets the same minimum activity score as above
• People with a life expectancy of at least 12 weeks
• People with liver cancer whose disease is Stage A, B, or C and whose liver function score meets the required threshold (confirm with trial site)
• People whose kidneys, liver, blood counts, and oxygen levels meet specific minimum values as determined by blood and other tests (confirm with trial site for exact values)
• People whose cancer has returned or stopped responding to standard treatment, and who have already completed at least one further round of treatment after that
• People who have recovered from the side effects of any previous cancer treatments
• People who are sexually active and willing to use effective contraception for 3 months after receiving the cell infusion
• People, or their legal guardian, who have been fully informed about the trial and have signed a consent form

Who may not be able to join:

For both the cell donation and treatment phases:

• People who have previously had an allergic reaction to products containing mouse proteins, or who have developed antibodies against mouse proteins as a result of prior treatment with mouse-derived therapies
• People who have previously had an organ transplant
• People who are known to be HIV positive
• People who currently have an active bacterial, fungal, or viral infection (note: Hepatitis B and Hepatitis C infections are exceptions to this rule — confirm with trial site)

For the treatment phase only:

• People who are pregnant or breastfeeding
• People with an infection that is not under control
• People currently taking systemic steroid medications at or above a certain dose, unless the dose has been reduced or stopped at least 24 hours before the planned cell infusion

Important: Always verify eligibility with the trial site directly before applying.