Lung Cancer Trial, Recruiting NCT06234579 Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Condition: Lung Cancer
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Lung Cancer Trial, Recruiting

NCT06234579
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been diagnosed with advanced non-small cell lung cancer (NSCLC) that has a specific genetic change called an ALK rearrangement, confirmed through detailed genetic testing of tumour tissue
  • People whose ALK rearrangement was originally detected by an earlier type of test may still be considered, as long as enough tumour tissue is available for the more detailed genetic test (confirm with trial site)
  • People who have already been treated with one of three specific medications — alectinib, brigatinib, or lorlatinib — for at least 28 days as their first treatment
  • People who are reasonably well and able to carry out daily activities, as assessed by a standard medical scale (ECOG performance score of 0, 1, or 2)
  • People who are 18 years of age or older at the time of their diagnosis
  • People who have signed a consent form approved by the local ethics committee

Who may not be able to join:

  • People whose lung cancer does not have the ALK rearrangement genetic change
  • People who stopped their ALK treatment early because of side effects, if there was no sign on scans that their cancer had grown or spread at that time

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 9 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: GIAMPAOLO TORTORA, Prof., Fondazione Policlinico Universitario A Gemelli

Phone: 3480510228

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
12 July 2021
Est. completion
31 March 2026

Where this trial is recruiting

🇮🇹 Italy

Primary endpoints

Percentage of patients with available NGS testing at diagnosis; Percentage of patients with available NGS re-testing after progession (either tissue or ctDNA) to first-line treatment with II-III generation ALK-Inhibitor

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 9 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov